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APEX1: apurinic/apyrimidinic endodeoxyribonuclease 1

1 protein, 128 patents, 1 drug, 1 trial, 4,298 NIH grants and 8,674 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolAPEX1HGNC
Nameapurinic/apyrimidinic endodeoxyribonuclease 1HGNC
NCBI Gene ID328NCBI Gene
HGNC IDHGNC:587HGNC
EnsemblENSG00000100823NCBI Gene
AliasesAPE, APE-1, APE1, APEN, APEX, APX, HAP1, REF-1, REF1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P27695DNA repair nuclease/redox regulator APEX131867Ensembl, GeneID, HGNCUniProt

Patents 128

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19362P27695Espacenet
WO 2025217591 A12025-10-1639P27695Espacenet
JP 2025517970 A2025-06-12362P27695Espacenet
JP 2025062604 A2025-04-145613P27695Espacenet
JP 2025062604 A2025-04-145614P27695Espacenet
JP 2025062604 A2025-04-145621P27695Espacenet
EP 4484957 A12025-01-0153P27695Espacenet
EP 4464338 A22024-11-20337P27695Espacenet
JP 2024123008 A2024-09-104860P27695Espacenet
JP 2024123008 A2024-09-104861P27695Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APX-3330CHEMBL578390DNA-(apurinic or apyrimidinic site) lyase inhibitorINHIBITORChEMBL

Trials 1

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04692688APX-3330PHASE2ClinicalTrials.gov

NIH grants 4298

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P01CA092584Structural Cell Biology of DNA Repair Machines572,025NIH's project files
P30CA016672Cancer Center Support Grant242,025NIH's project files
P30CA047904Cancer Center Support Grant232,025NIH's project files
ZIAAG000723ALZHEIMERS RESEARCH PROJECT: DNA repair dysfunction in neurodegeneration and Alzheimer's Disease232,025NIH's project files
P30CA082709Indiana University Melvin and Bren Simon Comprehensive Cancer Center Support Grant212,025NIH's project files
P30CA008748Cancer Center Support Grant172,025NIH's project files
ZIAAG000726Function of RecQ helicases in genome stability152,025NIH's project files
R35ES031638Watching cooperative interactions between base and nucleotide excision repair proteins142,025NIH's project files
ZIABC006150DNA Repair, Cell Cycle Checkpoints and Apoptosis as Targets for Anticancer Drugs142,025NIH's project files
P30ES010126UNC Center for Environmental Health and Susceptibility132,025NIH's project files

Papers 8674

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42815109PubTator, text miningPubMed
42806153PubTator, text miningPubMed
42777544PubTator, text miningPubMed
42754990PubTator, text miningPubMed
42743413PubTator, text miningPubMed
42739434PubTator, text miningPubMed
42735032PubTator, text miningPubMed
42711868PubTator, text miningPubMed
42702479PubTator, text miningPubMed
42697177PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license