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HES1: hes family bHLH transcription factor 1

1 protein, 57 patents, 0 drugs, 0 trials, 4,982 NIH grants and 8,271 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHES1HGNC
Namehes family bHLH transcription factor 1HGNC
NCBI Gene ID3280NCBI Gene
HGNC IDHGNC:5192HGNC
EnsemblENSG00000114315NCBI Gene
AliasesFLJ20408, HES-1, HHL, HRY, bHLHb39NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q14469Transcription factor HES-12802Ensembl, GeneID, HGNCUniProt

Patents 57

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448642Q14469Espacenet
EP 4650780 A22025-11-19823Q14469Espacenet
EP 4641202 A22025-10-294382Q14469Espacenet
JP 2025147176 A2025-10-0615070Q14469Espacenet
WO 2025164642 A2025-08-073Q14469Espacenet
JP 2025517970 A2025-06-12823Q14469Espacenet
JP 2025032204 A2025-03-1129537Q14469Espacenet
JP 2025028160 A2025-02-2815070Q14469Espacenet
KR 1020250017231 A2025-02-044382Q14469Espacenet
KR 1020250010750 A2025-01-2115070Q14469Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 4982

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant672,025NIH's project files
P30CA008748Cancer Center Support Grant332,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028192,025NIH's project files
P30CA016087Cancer Center Support Grant162,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program142,025NIH's project files
P30CA016520Abramson Cancer Center Support Grant132,025NIH's project files
P30CA006973Regional Oncology Research Center122,025NIH's project files
P30CA016058Cancer Center Support Grant122,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant122,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award122,025NIH's project files

Papers 8271

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42811039PubTator, text miningPubMed
42809705PubTator, text miningPubMed
42805446PubTator, text miningPubMed
42746303PubTator, text miningPubMed
42704010PubTator, text miningPubMed
42700816PubTator, text miningPubMed
42693576PubTator, text miningPubMed
42689967PubTator, text miningPubMed
42685494PubTator, text miningPubMed
42623479PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license