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BIRC2: baculoviral IAP repeat containing 2

1 protein, 85 patents, 1 drug, 11 trials, 2,586 NIH grants and 5,446 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolBIRC2HGNC
Namebaculoviral IAP repeat containing 2HGNC
NCBI Gene ID329NCBI Gene
HGNC IDHGNC:590HGNC
EnsemblENSG00000110330NCBI Gene
AliasesAPI1, HIAP2, Hiap-2, IAP-2, MIHB, RNF48, c-IAP1, cIAP1, hiap-2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q13490Baculoviral IAP repeat-containing protein 261829Ensembl, GeneID, HGNCUniProt

Patents 85

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19691Q13490Espacenet
JP 2025517970 A2025-06-12691Q13490Espacenet
JP 2025062604 A2025-04-148170Q13490Espacenet
JP 2025062604 A2025-04-148178Q13490Espacenet
JP 2024123008 A2024-09-104983Q13490Espacenet
US 12023385 B22024-07-0219Q13490Espacenet
US 11708396 B22023-07-251589Q13490Espacenet
US 11708396 B22023-07-251593Q13490Espacenet
WO 2023068278 A2023-04-271Q13490Espacenet
US 11590197 B22023-02-282Q13490Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BIRINAPANTCHEMBL3039522cIAP1/cIAP2 inhibitorINHIBITORChEMBL

Trials 11

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04553692BIRINAPANTPHASE1ClinicalTrials.gov
NCT03803774BIRINAPANTPHASE12024-07-23ClinicalTrials.gov
NCT02756130BIRINAPANTPHASE1/PHASE2ClinicalTrials.gov
NCT02587962BIRINAPANTPHASE1/PHASE22021-01-14ClinicalTrials.gov
NCT02288208BIRINAPANTPHASE1ClinicalTrials.gov
NCT02147873BIRINAPANTPHASE2ClinicalTrials.gov
NCT01940172BIRINAPANTPHASE1ClinicalTrials.gov
NCT01828346BIRINAPANTPHASE1/PHASE2ClinicalTrials.gov
NCT01681368BIRINAPANTPHASE22015-02-03ClinicalTrials.gov
NCT01486784BIRINAPANTPHASE1/PHASE22021-05-13ClinicalTrials.gov

NIH grants 2586

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant642,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028222,025NIH's project files
P30CA008748Cancer Center Support Grant162,025NIH's project files
P30CA030199Cancer Center Support Grant (CCSG)102,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant92,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase82,025NIH's project files
P30DK084567Mayo Center for Cell Signaling in Gastroenterology82,025NIH's project files
UM1AI068616SDMC - IMPAACT Leadership Group72,025NIH's project files
UM1AI068632IMPAACT Leadership Group72,025NIH's project files
UM1AI106716International Maternal, Adolescent and Pediatric Therapeutics Clinical Trials Network72,025NIH's project files

Papers 5446

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42807107PubTator, text miningPubMed
42786362PubTator, text miningPubMed
42734562PubTator, text miningPubMed
42709209PubTator, text miningPubMed
42656404PubTator, text miningPubMed
42473593PubTator, text miningPubMed
42444891PubTator, text miningPubMed
42426915PubTator, text miningPubMed
42335979PubTator, text miningPubMed
42268368PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license