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Gene · 3291

HSD11B2: hydroxysteroid 11-beta dehydrogenase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HSD11B2: hydroxysteroid 11-beta dehydrogenase 2. Genes, record 3291. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3291

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Gene

Symbol
HSD11B2
HGNC
Name
hydroxysteroid 11-beta dehydrogenase 2
HGNC
NCBI Gene ID
3291
NCBI Gene
HGNC ID
HGNC:5209
HGNC
Ensembl
ENSG00000176387
NCBI Gene
Aliases
AME, AME1, HSD11K, HSD2, SDR9C3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P8036511-beta-hydroxysteroid dehydrogenase type 24050Ensembl, GeneID, HGNC

Source UniProt

Patents15

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449542P80365Espacenet
JP 2025529142 A2025-09-041990P80365Espacenet
US 12371689 B22025-07-291990P80365Espacenet
US 11446398 B22022-09-2039293P80365Espacenet
JP 2022524081 A2022-04-27142264P80365Espacenet
US 11078247 B22021-08-035181P80365Espacenet
WO 2020043864 A12020-03-05685P80365Espacenet
JP 2019158777 A2019-09-191101P80365Espacenet
JP 2019054813 A2019-04-11229977P80365Espacenet
JP 2017527290 A2017-09-2116P80365Espacenet

1 to 10 of 15

See all 15 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
CARBENOXOLONECHEMBL49991511-beta-hydroxysteroid dehydrogenase inhibitorINHIBITOR

Source ChEMBL

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,755

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHSD11B2 papersNewest fiscal year
P30ES017885Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)152025
P30ES023515Mount Sinai Center for Health and Environment Across the LifeSpan (HEALS)152025
R01ES013744Stress-Air Pollution Interactions and Adolescent Neurobehavior102025
ZIAES090057Glucocorticoid Hormone Action102025
T32HD049311Research Training Program in Pediatric Exposomics92025
P30CA023108Cancer Center Support Grant82025
P30DK020572Michigan Diabetes Research Center (MDRC)72025
R01GM086596Activation of androgen biosynthesis and drug metabolism by cytochrome b572025
P30ES013508Center of Excellence in Environmental Toxicology62025
R35ES031686Environmental Epigenomics and Precision Environmental Health62025

1 to 10 of 1,755Source NIH's project files

See all 1,755 nih grants

Papers3,649

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Statement of Retraction: Sufentanil alleviates pre-eclampsia via silencing microRNA-24-3p to target 11β-Hydroxysteroid dehydrogenase type 2.Bioengineered202642821410PubTator, text miningPubMed
Monogenic Kidney Disorders as Hidden Drivers of Electrolyte Imbalance and Hypertension.Electrolyte Blood Press202642812492PubTator, text miningPubMed
Placental DNA Methylation of HSD11B2 and IGF2 Is Associated With Fetal Growth in the Cebu Longitudinal Health and Nutrition Survey.Am J Hum Biol202642811810PubTator, text miningPubMed
Chronic Stress and the Brain-Kidney Axis in Renal Injury: From Neuroendocrine Dysregulation to Kidney Damage.Int J Mol Sci202642794778PubTator, text miningPubMed
Integrative multi-omics analysis prioritizes compartment-specific candidate targets of gut microbiota metabolites in diabetic kidney disease.Front Immunol202642756821PubTator, text miningPubMed
Perinatal HPA axis regulation and offspring neuropsychiatric development: mechanisms, developmental trajectories, and clinical implications.Front Endocrinol (Lausanne)202642729771PubTator, text miningPubMed
11β-HSD2 buffers fetal glucocorticoid exposure inducing Per1 expression under maternal stress.PNAS Nexus202642703617PubTator, text miningPubMed
Pharmacokinetic and Pharmacodynamic Interactions Between Anti-Asthma Drugs and Medicinal Plants: A Comprehensive Review.Phytother Res202642702401PubTator, text miningPubMed
Immune signatures associated with human adrenocortical hypertension.Eur J Endocrinol202642695495PubTator, text miningPubMed
Industrial phenolic compounds targeting 11β-hydroxysteroid dehydrogenase 2: A comparative in silico and structure-activity investigation in humans and rats.Ecotoxicol Environ Saf202642612382PubTator, text miningPubMed

1 to 10 of 3,649

See all 3,649 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3291

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