Gene · 3291
HSD11B2: hydroxysteroid 11-beta dehydrogenase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. HSD11B2: hydroxysteroid 11-beta dehydrogenase 2. Genes, record 3291. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3291
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P80365 | 11-beta-hydroxysteroid dehydrogenase type 2 | 405 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents15
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 49542 | P80365 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1990 | P80365 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1990 | P80365 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 39293 | P80365 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 142264 | P80365 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 5181 | P80365 | Espacenet |
| WO 2020043864 A1 | 2020-03-05 | 685 | P80365 | Espacenet |
| JP 2019158777 A | 2019-09-19 | 1101 | P80365 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 229977 | P80365 | Espacenet |
| JP 2017527290 A | 2017-09-21 | 16 | P80365 | Espacenet |
1 to 10 of 15
See all 15 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| CARBENOXOLONE | CHEMBL499915 | 11-beta-hydroxysteroid dehydrogenase inhibitor | INHIBITOR |
Source ChEMBL
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,755
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | HSD11B2 papers | Newest fiscal year |
|---|---|---|---|
| P30ES017885 | Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) | 15 | 2025 |
| P30ES023515 | Mount Sinai Center for Health and Environment Across the LifeSpan (HEALS) | 15 | 2025 |
| R01ES013744 | Stress-Air Pollution Interactions and Adolescent Neurobehavior | 10 | 2025 |
| ZIAES090057 | Glucocorticoid Hormone Action | 10 | 2025 |
| T32HD049311 | Research Training Program in Pediatric Exposomics | 9 | 2025 |
| P30CA023108 | Cancer Center Support Grant | 8 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 7 | 2025 |
| R01GM086596 | Activation of androgen biosynthesis and drug metabolism by cytochrome b5 | 7 | 2025 |
| P30ES013508 | Center of Excellence in Environmental Toxicology | 6 | 2025 |
| R35ES031686 | Environmental Epigenomics and Precision Environmental Health | 6 | 2025 |
1 to 10 of 1,755Source NIH's project files
See all 1,755 nih grantsPapers3,649
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Statement of Retraction: Sufentanil alleviates pre-eclampsia via silencing microRNA-24-3p to target 11β-Hydroxysteroid dehydrogenase type 2. | Bioengineered | 2026 | 42821410 | PubTator, text mining | PubMed |
| Monogenic Kidney Disorders as Hidden Drivers of Electrolyte Imbalance and Hypertension. | Electrolyte Blood Press | 2026 | 42812492 | PubTator, text mining | PubMed |
| Placental DNA Methylation of HSD11B2 and IGF2 Is Associated With Fetal Growth in the Cebu Longitudinal Health and Nutrition Survey. | Am J Hum Biol | 2026 | 42811810 | PubTator, text mining | PubMed |
| Chronic Stress and the Brain-Kidney Axis in Renal Injury: From Neuroendocrine Dysregulation to Kidney Damage. | Int J Mol Sci | 2026 | 42794778 | PubTator, text mining | PubMed |
| Integrative multi-omics analysis prioritizes compartment-specific candidate targets of gut microbiota metabolites in diabetic kidney disease. | Front Immunol | 2026 | 42756821 | PubTator, text mining | PubMed |
| Perinatal HPA axis regulation and offspring neuropsychiatric development: mechanisms, developmental trajectories, and clinical implications. | Front Endocrinol (Lausanne) | 2026 | 42729771 | PubTator, text mining | PubMed |
| 11β-HSD2 buffers fetal glucocorticoid exposure inducing Per1 expression under maternal stress. | PNAS Nexus | 2026 | 42703617 | PubTator, text mining | PubMed |
| Pharmacokinetic and Pharmacodynamic Interactions Between Anti-Asthma Drugs and Medicinal Plants: A Comprehensive Review. | Phytother Res | 2026 | 42702401 | PubTator, text mining | PubMed |
| Immune signatures associated with human adrenocortical hypertension. | Eur J Endocrinol | 2026 | 42695495 | PubTator, text mining | PubMed |
| Industrial phenolic compounds targeting 11β-hydroxysteroid dehydrogenase 2: A comparative in silico and structure-activity investigation in humans and rats. | Ecotoxicol Environ Saf | 2026 | 42612382 | PubTator, text mining | PubMed |
1 to 10 of 3,649
See all 3,649 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3291
GET https://conductscience.org/api/genes/v1/3291/patents