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Gene · 3292

HSD17B1: hydroxysteroid 17-beta dehydrogenase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HSD17B1: hydroxysteroid 17-beta dehydrogenase 1. Genes, record 3292. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3292

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Gene

Symbol
HSD17B1
HGNC
Name
hydroxysteroid 17-beta dehydrogenase 1
HGNC
NCBI Gene ID
3292
NCBI Gene
HGNC ID
HGNC:5210
HGNC
Ensembl
ENSG00000108786
NCBI Gene
Aliases
17-beta-HSD, 20-alpha-HSD, E2DH, EDH17B2, EDHB17, HSD17, MGC138140, SDR28C1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P1406117-beta-hydroxysteroid dehydrogenase type 132828Ensembl, GeneID, HGNC

Source UniProt

Patents15

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449544P14061Espacenet
JP 2026004568 A2026-01-1449545P14061Espacenet
US 11446398 B22022-09-2039297P14061Espacenet
JP 2022524081 A2022-04-27142268P14061Espacenet
KR 1020210125456 A2021-10-1812P14061Espacenet
US 11078247 B22021-08-035187P14061Espacenet
JP 2019054813 A2019-04-11229979P14061Espacenet
JP 2019054813 A2019-04-11229980P14061Espacenet
JP 2017121241 A2017-07-13229979P14061Espacenet
JP 2017121241 A2017-07-13229980P14061Espacenet

1 to 10 of 15

See all 15 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,127

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHSD17B1 papersNewest fiscal year
P30ES013508Center of Excellence in Environmental Toxicology192025
T32ES007326Interdisciplinary Research Training Program in Environmental Health and Toxicology82025
R01CA172382Elucidating a novel molecular biomarker for castration-resistant prostate cancer62025
P01CA163227Androgen Receptor Action in Castration Resistant Prostate Cancer52025
T32DK007314Diabetes, Endocrine, and Metabolism42025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures42025
P30CA016056Roswell Park Cancer Center Support Grant32025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant32025
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)32025
P50CA097186The Pacific Northwest Prostate Cancer SPORE32025

1 to 10 of 1,127Source NIH's project files

See all 1,127 nih grants

Papers2,290

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Dietary vitamin C improves reproductive performance by increasing antioxidant capacity, steroid hormone concentration and expression of genes involved in steroid hormone synthesis in Yangzhou geese.Br Poult Sci202642813264PubTator, text miningPubMed
Molecular Mechanisms of Endocrine-Disrupting Chemicals and Emerging-Pollutant Toxicity in Human Reproduction: From Xenobiotic Exposure to Fertility Impairment and Reproductive Carcinogenesis.Int J Mol Sci202642737662PubTator, text miningPubMed
A Phase 2a/b, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Study to Evaluate the Efficacy and Safety of Linustedastat (OG-6219) in Women with Moderate to Severe Endometriosis-Related Pain.
Int J Womens Health202642733850PubTator, text miningPubMed
Association of organophosphate flame retardant exposure with female infertility: Cross-sectional and mechanistic evidence.Ecotoxicol Environ Saf202642710202PubTator, text miningPubMed
Saliva-based RT-LAMP assays support heat shock protein 70 as a promising transcript marker for estrus identification in buffaloes.Trop Anim Health Prod202642709327PubTator, text miningPubMed
Serum Peptidomic Analysis in a Comparative Study of the Efficacy of Benjakul Remedy Versus Loratadine in Allergic Rhinitis Patients.Int J Mol Sci202642653391PubTator, text miningPubMed
Design, synthesis, and preliminary antiproliferative evaluation of azetidine-functionalized pyrrolo[2,3-d]pyrimidines with integrated computational studies.J Biomol Struct Dyn202642627359PubTator, text miningPubMed
Effects of PFOS and its substitute PFHxS on steroid hormone secretion, uptake, and transport in BeWo cells.Ecotoxicol Environ Saf202642561515PubTator, text miningPubMed
Identification of genes differentially expressed in granulosa cells from women with high vs. low ovarian responsiveness.Front Reprod Health202642358728PubTator, text miningPubMed
Targeting Steroid-Metabolizing Enzymes with 15β-Substituted Estrone Analogues: Dual Discovery of AKR1C2/17β-HSD1 Inhibitors and a Fluorescent 17β-HSD1 Ligand.Cancers (Basel)202642352425PubTator, text miningPubMed

1 to 10 of 2,290

See all 2,290 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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