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Gene · 3304

HSPA1B: heat shock protein family A (Hsp70) member 1B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HSPA1B: heat shock protein family A (Hsp70) member 1B. Genes, record 3304. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3304

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Gene

Symbol
HSPA1B
HGNC
Name
heat shock protein family A (Hsp70) member 1B
HGNC
NCBI Gene ID
3304
NCBI Gene
HGNC ID
HGNC:5233
HGNC
Ensembl
ENSG00000204388
NCBI Gene
Aliases
HSP70-1, HSP70-1B, HSP70-2, HSP70.1, HSP70.2, HSP72, HSPA1, HSX70
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins2

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P0DMV8Heat shock 70 kDa protein 1A64175Ensembl, GeneIDUniProt
P0DMV9Heat shock 70 kDa protein 1B6415Ensembl, GeneID, HGNCUniProt

Patents670

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4822355 A22026-10-141P0DMV8Espacenet
EP 4822355 A22026-10-141P0DMV9Espacenet
EP 4822355 A22026-10-144P0DMV8Espacenet
EP 4822355 A22026-10-144P0DMV9Espacenet
JP 2026086489 A2026-05-2611P0DMV8Espacenet
JP 2026086489 A2026-05-2611P0DMV9Espacenet
JP 2026004568 A2026-01-1448739P0DMV8Espacenet
JP 2026004568 A2026-01-1448739P0DMV9Espacenet
JP 2026004568 A2026-01-1448744P0DMV8Espacenet
JP 2026004568 A2026-01-1448744P0DMV9Espacenet

1 to 10 of 670

See all 670 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
CD24FCCHEMBL4297717Heat shock 70 kDa protein 1A/1B inhibitorINHIBITOR

Source ChEMBL

Trials3

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04317040CD24FCPHASE32021-10-15ClinicalTrials.gov
NCT04060407CD24FCPHASE1/PHASE2ClinicalTrials.gov
NCT03960541CD24FCPHASE22022-06-08ClinicalTrials.gov

NIH grants1,699

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHSPA1B papersNewest fiscal year
P30CA008748Cancer Center Support Grant102025
P30CA016672Cancer Center Support Grant62025
R01GM058460Chromatin Domain Structure and Function52025
R01NS059690Molecular Chaperones and Small Molecules52025
P30CA006927Comprehensive Cancer Center Program at Fox Chase42025
P30CA016056Roswell Park Cancer Center Support Grant42025
P30CA016087Cancer Center Support Grant42025
P30CA046934University of Colorado Cancer Center Support Grant42025
P30CA047904Cancer Center Support Grant42025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant42025

1 to 10 of 1,699Source NIH's project files

See all 1,699 nih grants

Papers2,276

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Cell-Type-Specific HSPA1B Expression Links COPD and Atherosclerosis.Immun Inflamm Dis202642806886PubTator, text miningPubMed
Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage-Specific Vulnerabilities in Alzheimer's Disease.Adv Sci (Weinh)202642750204PubTator, text miningPubMed
Exploratory Cross-Cohort Transcriptomic Comparison of Coronary Artery Disease and Non-Obstructive Azoospermia.Int J Mol Sci202642737806PubTator, text miningPubMed
PRRSV N protein antagonizes host antiviral immune responses by upregulating HSPA1B to induce autophagic degradation of Fos-related antigen 1.mBio202642627167PubTator, text miningPubMed
Stage-Specific Gene Expression Profiles in Multiple Sclerosis Cortical Lesions Identified via Spatial Transcriptomics.OMICS202642605943PubTator, text miningPubMed
Nuclear speckle-associated perispeckle networks partition active chromatin into gene expression niches.Cell Rep202642603274PubTator, text miningPubMed
CFTR functions as a tumor suppressor in adenoid cystic carcinoma and its silencing reveals an associated vulnerability involving the Hsp70 chaperone system.Front Oncol202642518810PubTator, text miningPubMed
Genetic Analysis of the HSPA1A, HSPA1B, and HSPA1L Genes in Patients with Schizophrenia from Taiwan.Genes (Basel)202642510767PubTator, text miningPubMed
Engineering Stable Lentiviral Vector Producer Cells Improves LVV Production.Biotechnol Bioeng202642478279PubTator, text miningPubMed
Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS-CT1 Study.Ann Clin Transl Neurol202642420815PubTator, text miningPubMed

1 to 10 of 2,276

See all 2,276 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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