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HSPA5: heat shock protein family A (Hsp70) member 5

1 protein, 215 patents, 0 drugs, 0 trials, 7,869 NIH grants and 18,855 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHSPA5HGNC
Nameheat shock protein family A (Hsp70) member 5HGNC
NCBI Gene ID3309NCBI Gene
HGNC IDHGNC:5238HGNC
EnsemblENSG00000044574NCBI Gene
AliasesBIP, BiP, GRP78, HEL-S-89nNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P11021Endoplasmic reticulum chaperone BiP65433Ensembl, GeneID, HGNCUniProt

Patents 215

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4752548 A12026-06-0310P11021Espacenet
JP 2026004568 A2026-01-1448796P11021Espacenet
EP 4650780 A22025-11-195537P11021Espacenet
JP 2025147176 A2025-10-066609P11021Espacenet
JP 2025529142 A2025-09-046621P11021Espacenet
US 12371689 B22025-07-296621P11021Espacenet
EP 4573120 A12025-06-2525P11021Espacenet
JP 2025517970 A2025-06-125537P11021Espacenet
KR 1020250083159 A2025-06-0921P11021Espacenet
EP 4551586 A12025-05-1425P11021Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 7869

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant552,025NIH's project files
P30CA008748Cancer Center Support Grant322,025NIH's project files
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)302,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)292,025NIH's project files
P30CA016059Massey Cancer Center - Cancer Center Support Grant232,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program192,025NIH's project files
P30DK020579Diabetes Research Center192,025NIH's project files
P30ES006694Southwest Environmental Health Sciences Center192,025NIH's project files
P50AA011999Southern California Research Center for ALPD and Cirrhosis192,025NIH's project files
R01NS059690Molecular Chaperones and Small Molecules182,025NIH's project files

Papers 18855

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825362PubTator, text miningPubMed
42815653PubTator, text miningPubMed
42810633PubTator, text miningPubMed
42800448PubTator, text miningPubMed
42795389PubTator, text miningPubMed
42790022PubTator, text miningPubMed
42785656PubTator, text miningPubMed
42782316PubTator, text miningPubMed
42772762PubTator, text miningPubMed
42766610PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license