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HSPA8: heat shock protein family A (Hsp70) member 8

1 protein, 162 patents, 2 drugs, 4 trials, 4,805 NIH grants and 9,120 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHSPA8HGNC
Nameheat shock protein family A (Hsp70) member 8HGNC
NCBI Gene ID3312NCBI Gene
HGNC IDHGNC:5241HGNC
EnsemblENSG00000109971NCBI Gene
AliasesHEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P11142Heat shock cognate 71 kDa protein64638Ensembl, GeneID, HGNCUniProt

Patents 162

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4689130 A22026-02-11136P11142Espacenet
JP 2026004568 A2026-01-1448800P11142Espacenet
JP 2026004568 A2026-01-1448803P11142Espacenet
JP 2026004568 A2026-01-1448806P11142Espacenet
EP 4650780 A22025-11-19680P11142Espacenet
EP 4641201 A22025-10-29475P11142Espacenet
EP 4641202 A22025-10-294359P11142Espacenet
US 12433933 B22025-10-0769P11142Espacenet
US 12433933 B22025-10-0770P11142Espacenet
US 12433933 B22025-10-079P11142Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
FORIGERIMODCHEMBL3989409Heat shock cognate 71 kDa protein inhibitorINHIBITORChEMBL
FORIGERIMOD ACETATECHEMBL3989801Heat shock cognate 71 kDa protein inhibitorINHIBITORChEMBL

Trials 4

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT03427151FORIGERIMODPHASE3ClinicalTrials.gov
NCT02504645FORIGERIMODPHASE32019-04-11ClinicalTrials.gov
NCT01240694FORIGERIMOD ACETATEPHASE32022-12-30ClinicalTrials.gov
NCT01135459FORIGERIMOD ACETATEPHASE22022-12-16ClinicalTrials.gov

NIH grants 4805

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01NS059690Molecular Chaperones and Small Molecules532,025NIH's project files
P30CA008748Cancer Center Support Grant432,025NIH's project files
P30CA016672Cancer Center Support Grant222,025NIH's project files
P30CA036727Buffett Cancer Center Support Grant192,025NIH's project files
R01NS073899The hsp90 Cochaperone FKBP51 Regulates tau Structure and Function162,025NIH's project files
P30CA047904Cancer Center Support Grant132,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center122,025NIH's project files
P30ES006694Southwest Environmental Health Sciences Center122,025NIH's project files
P30CA013330Cancer Center Support Grant102,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)102,025NIH's project files

Papers 9120

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42791102PubTator, text miningPubMed
42784431PubTator, text miningPubMed
42776282PubTator, text miningPubMed
42758966PubTator, text miningPubMed
42738372PubTator, text miningPubMed
42728394PubTator, text miningPubMed
42715840PubTator, text miningPubMed
42698533PubTator, text miningPubMed
42667615PubTator, text miningPubMed
42661225PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license