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HSPB1: heat shock protein family B (small) member 1

1 protein, 144 patents, 2 drugs, 9 trials, 4,085 NIH grants and 9,162 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHSPB1HGNC
Nameheat shock protein family B (small) member 1HGNC
NCBI Gene ID3315NCBI Gene
HGNC IDHGNC:5246HGNC
EnsemblENSG00000106211NCBI Gene
AliasesCMT2F, HEL-S-102, HMN2B, HMND3, HS.76067, HSP27, HSP28, Hs.76067, Hsp25, SRP27NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P04792Heat shock protein beta-12057Ensembl, GeneID, HGNCUniProt

Patents 144

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4762184 A22026-06-24101P04792Espacenet
EP 4762184 A22026-06-2418P04792Espacenet
EP 4762184 A22026-06-24305P04792Espacenet
EP 4762184 A22026-06-24327P04792Espacenet
EP 4762184 A22026-06-24402P04792Espacenet
WO 2026063308 A2026-03-266P04792Espacenet
EP 4689130 A22026-02-11124P04792Espacenet
EP 4650780 A22025-11-191248P04792Espacenet
EP 4641202 A22025-10-294439P04792Espacenet
US 12448654 B22025-10-212P04792Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APATORSENCHEMBL3039556Heat shock protein beta-1 (HSP27) mRNA antisense inhibitorANTISENSE INHIBITORChEMBL
APATORSEN SODIUMCHEMBL3039553Heat shock protein beta-1 (HSP27) mRNA antisense inhibitorANTISENSE INHIBITORChEMBL

Trials 9

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02423590APATORSENPHASE2ClinicalTrials.gov
NCT01844817APATORSENPHASE22017-05-16ClinicalTrials.gov
NCT01829113APATORSENPHASE22018-06-08ClinicalTrials.gov
NCT01780545APATORSENPHASE22017-11-14ClinicalTrials.gov
NCT01681433APATORSENPHASE22018-10-18ClinicalTrials.gov
NCT01454089APATORSEN SODIUMPHASE2ClinicalTrials.gov
NCT01454089APATORSENPHASE2ClinicalTrials.gov
NCT01120470APATORSENPHASE2ClinicalTrials.gov
NCT00487786APATORSENPHASE1ClinicalTrials.gov

NIH grants 4085

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant342,025NIH's project files
P30CA008748Cancer Center Support Grant132,025NIH's project files
P30CA047904Cancer Center Support Grant122,025NIH's project files
P30DK042086Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID)102,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant92,025NIH's project files
P30CA054174Mays Cancer Center at UT Health SA92,025NIH's project files
P30ES006694Southwest Environmental Health Sciences Center92,025NIH's project files
R01NS059690Molecular Chaperones and Small Molecules82,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program72,025NIH's project files
P30CA016086Cancer Center Support Grant72,025NIH's project files

Papers 9162

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42787484PubTator, text miningPubMed
42778872PubTator, text miningPubMed
42747073PubTator, text miningPubMed
42731420PubTator, text miningPubMed
42707803PubTator, text miningPubMed
42700015PubTator, text miningPubMed
42684887PubTator, text miningPubMed
42680832PubTator, text miningPubMed
42676063PubTator, text miningPubMed
42643993PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license