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HSP90AA1: heat shock protein 90 alpha family class A member 1

1 protein, 137 patents, 10 drugs, 134 trials, 13,547 NIH grants and 32,900 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHSP90AA1HGNC
Nameheat shock protein 90 alpha family class A member 1HGNC
NCBI Gene ID3320NCBI Gene
HGNC IDHGNC:5253HGNC
EnsemblENSG00000080824NCBI Gene
AliasesEL52, FLJ31884, HEL-S-65p, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp103, Hsp89, Hsp90, LAP-2, LAP2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P07900Heat shock protein HSP 90-alpha732446Ensembl, GeneID, HGNCUniProt

Patents 137

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026120675 A2026-07-22777P07900Espacenet
EP 4650780 A22025-11-19331P07900Espacenet
EP 4641201 A22025-10-29248P07900Espacenet
JP 2025517969 A2025-06-12248P07900Espacenet
JP 2025517970 A2025-06-12331P07900Espacenet
JP 2025032204 A2025-03-1129689P07900Espacenet
KR 1020250020708 A2025-02-1119P07900Espacenet
JP 2024167327 A2024-12-0319P07900Espacenet
EP 4461818 A22024-11-1329689P07900Espacenet
JP 2024123008 A2024-09-106414P07900Espacenet

Drugs 10

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALVESPIMYCINCHEMBL383824Heat shock protein HSP90 inhibitorINHIBITORChEMBL
BIIB021CHEMBL467399Heat shock protein HSP90 inhibitorINHIBITORChEMBL
CD24FCCHEMBL4297717Heat shock protein HSP90 inhibitorINHIBITORChEMBL
GANETESPIBCHEMBL2103879Heat shock protein HSP90 inhibitorINHIBITORChEMBL
LUMINESPIBCHEMBL252164Heat shock protein HSP90 inhibitorINHIBITORChEMBL
ONALESPIBCHEMBL1214827Heat shock protein HSP90 inhibitorINHIBITORChEMBL
RETASPIMYCINCHEMBL1184904Heat shock protein HSP90 inhibitorINHIBITORChEMBL
RETASPIMYCIN HYDROCHLORIDECHEMBL377559Heat shock protein HSP90 inhibitorINHIBITORChEMBL
SNX 5422CHEMBL1195136Heat shock protein HSP90 inhibitorINHIBITORChEMBL
TANESPIMYCINCHEMBL109480Heat shock protein HSP90 inhibitorINHIBITORChEMBL

Trials 134

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04317040CD24FCPHASE32021-10-15ClinicalTrials.gov
NCT04060407CD24FCPHASE1/PHASE2ClinicalTrials.gov
NCT03960541CD24FCPHASE22022-06-08ClinicalTrials.gov
NCT03783949GANETESPIBPHASE22025-06-11ClinicalTrials.gov
NCT02973399SNX 5422PHASE1ClinicalTrials.gov
NCT02914327SNX 5422PHASE1ClinicalTrials.gov
NCT02898207ONALESPIBPHASE12023-04-26ClinicalTrials.gov
NCT02637375GANETESPIBClinicalTrials.gov
NCT02627430ONALESPIBPHASE1ClinicalTrials.gov
NCT02612285SNX 5422PHASE22018-11-14ClinicalTrials.gov

NIH grants 13547

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1972,025NIH's project files
P30CA016672Cancer Center Support Grant1662,025NIH's project files
ZIASC010074HSP90 and HSP70 Chaperone Proteins and Interactors in Cellular Signal Transduction1112,025NIH's project files
ZIABC011032Post-translational modifications of Hsp90662,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program592,025NIH's project files
R01NS059690Molecular Chaperones and Small Molecules512,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant482,025NIH's project files
P30CA006973Regional Oncology Research Center432,025NIH's project files
P30CA047904Cancer Center Support Grant412,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase352,025NIH's project files

Papers 32900

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826913PubTator, text miningPubMed
42821566PubTator, text miningPubMed
42817178PubTator, text miningPubMed
42817101PubTator, text miningPubMed
42812104PubTator, text miningPubMed
42811766PubTator, text miningPubMed
42811115PubTator, text miningPubMed
42808411PubTator, text miningPubMed
42802180PubTator, text miningPubMed
42801585PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license