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Gene · 3326

HSP90AB1: heat shock protein 90 alpha family class B member 1

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. HSP90AB1: heat shock protein 90 alpha family class B member 1. Genes, record 3326. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/3326

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
HSP90AB1
HGNC
Name
heat shock protein 90 alpha family class B member 1
HGNC
NCBI Gene ID
3326
NCBI Gene
HGNC ID
HGNC:5258
HGNC
Ensembl
ENSG00000096384
NCBI Gene
Aliases
D6S182, HSP84, HSP90B, HSPC2, HSPCB
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P08238Heat shock protein HSP 90-beta72432Ensembl, GeneID, HGNC

Source UniProt

Patents186

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448810P08238Espacenet
JP 2026004568 A2026-01-1448811P08238Espacenet
JP 2026004568 A2026-01-1448815P08238Espacenet
EP 4650780 A22025-11-195631P08238Espacenet
EP 4641201 A22025-10-295274P08238Espacenet
EP 4641202 A22025-10-294985P08238Espacenet
JP 2025517969 A2025-06-125274P08238Espacenet
JP 2025517970 A2025-06-125631P08238Espacenet
JP 2025032204 A2025-03-1129695P08238Espacenet
JP 2025032204 A2025-03-1129696P08238Espacenet

1 to 10 of 186

See all 186 patents

Drugs10

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALVESPIMYCINCHEMBL383824Heat shock protein HSP90 inhibitorINHIBITORChEMBL
BIIB021CHEMBL467399Heat shock protein HSP90 inhibitorINHIBITORChEMBL
CD24FCCHEMBL4297717Heat shock protein HSP90 inhibitorINHIBITORChEMBL
GANETESPIBCHEMBL2103879Heat shock protein HSP90 inhibitorINHIBITORChEMBL
LUMINESPIBCHEMBL252164Heat shock protein HSP90 inhibitorINHIBITORChEMBL
ONALESPIBCHEMBL1214827Heat shock protein HSP90 inhibitorINHIBITORChEMBL
RETASPIMYCINCHEMBL1184904Heat shock protein HSP90 inhibitorINHIBITORChEMBL
RETASPIMYCIN HYDROCHLORIDECHEMBL377559Heat shock protein HSP90 inhibitorINHIBITORChEMBL
SNX 5422CHEMBL1195136Heat shock protein HSP90 inhibitorINHIBITORChEMBL
TANESPIMYCINCHEMBL109480Heat shock protein HSP90 inhibitorINHIBITORChEMBL

Trials134

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04317040CD24FCPHASE32021-10-15ClinicalTrials.gov
NCT04060407CD24FCPHASE1/PHASE2ClinicalTrials.gov
NCT03960541CD24FCPHASE22022-06-08ClinicalTrials.gov
NCT03783949GANETESPIBPHASE22025-06-11ClinicalTrials.gov
NCT02973399SNX 5422PHASE1ClinicalTrials.gov
NCT02914327SNX 5422PHASE1ClinicalTrials.gov
NCT02898207ONALESPIBPHASE12023-04-26ClinicalTrials.gov
NCT02637375GANETESPIBClinicalTrials.gov
NCT02627430ONALESPIBPHASE1ClinicalTrials.gov
NCT02612285SNX 5422PHASE22018-11-14ClinicalTrials.gov

1 to 10 of 134

See all 134 trials

NIH grants2,477

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
P30CA008748Cancer Center Support Grant382025
ZIASC010074HSP90 and HSP70 Chaperone Proteins and Interactors in Cellular Signal Transduction212025
ZIABC011032Post-translational modifications of Hsp90172025
P30CA016672Cancer Center Support Grant102025
P30CA076292Moffitt Cancer Center Support Grant102025
R01NS059690Molecular Chaperones and Small Molecules92025
R01AG067598Chaperome networks in Alzheimer's disease82025
R01NS073899The hsp90 Cochaperone FKBP51 Regulates tau Structure and Function82025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant72025
P30ES006694Southwest Environmental Health Sciences Center72025

1 to 10 of 2,477Source NIH's project files

See all 2,477 nih grants

Papers4,343

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822389PubTator, text miningPubMed
42799811PubTator, text miningPubMed
42793153PubTator, text miningPubMed
42764310PubTator, text miningPubMed
42758966PubTator, text miningPubMed
42758207PubTator, text miningPubMed
42757385PubTator, text miningPubMed
42700511PubTator, text miningPubMed
42675534PubTator, text miningPubMed
42675068PubTator, text miningPubMed

1 to 10 of 4,343

See all 4,343 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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