Gene · 3326
HSP90AB1: heat shock protein 90 alpha family class B member 1
11 sourcesgene-search-2026-11-11-0.1.0
Cite this record
ConductScience Library. HSP90AB1: heat shock protein 90 alpha family class B member 1. Genes, record 3326. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/3326
On this page
Gene
Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P08238 | Heat shock protein HSP 90-beta | 724 | 32 | Ensembl, GeneID, HGNC |
Source UniProt
Patents186
Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 48810 | P08238 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 48811 | P08238 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 48815 | P08238 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 5631 | P08238 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 5274 | P08238 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4985 | P08238 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 5274 | P08238 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 5631 | P08238 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 29695 | P08238 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 29696 | P08238 | Espacenet |
1 to 10 of 186
See all 186 patentsDrugs10
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ALVESPIMYCIN | CHEMBL383824 | Heat shock protein HSP90 inhibitor | INHIBITOR | ChEMBL |
| BIIB021 | CHEMBL467399 | Heat shock protein HSP90 inhibitor | INHIBITOR | ChEMBL |
| CD24FC | CHEMBL4297717 | Heat shock protein HSP90 inhibitor | INHIBITOR | ChEMBL |
| GANETESPIB | CHEMBL2103879 | Heat shock protein HSP90 inhibitor | INHIBITOR | ChEMBL |
| LUMINESPIB | CHEMBL252164 | Heat shock protein HSP90 inhibitor | INHIBITOR | ChEMBL |
| ONALESPIB | CHEMBL1214827 | Heat shock protein HSP90 inhibitor | INHIBITOR | ChEMBL |
| RETASPIMYCIN | CHEMBL1184904 | Heat shock protein HSP90 inhibitor | INHIBITOR | ChEMBL |
| RETASPIMYCIN HYDROCHLORIDE | CHEMBL377559 | Heat shock protein HSP90 inhibitor | INHIBITOR | ChEMBL |
| SNX 5422 | CHEMBL1195136 | Heat shock protein HSP90 inhibitor | INHIBITOR | ChEMBL |
| TANESPIMYCIN | CHEMBL109480 | Heat shock protein HSP90 inhibitor | INHIBITOR | ChEMBL |
Trials134
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT04317040 | CD24FC | PHASE3 | 2021-10-15 | ClinicalTrials.gov |
| NCT04060407 | CD24FC | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT03960541 | CD24FC | PHASE2 | 2022-06-08 | ClinicalTrials.gov |
| NCT03783949 | GANETESPIB | PHASE2 | 2025-06-11 | ClinicalTrials.gov |
| NCT02973399 | SNX 5422 | PHASE1 | ClinicalTrials.gov | |
| NCT02914327 | SNX 5422 | PHASE1 | ClinicalTrials.gov | |
| NCT02898207 | ONALESPIB | PHASE1 | 2023-04-26 | ClinicalTrials.gov |
| NCT02637375 | GANETESPIB | ClinicalTrials.gov | ||
| NCT02627430 | ONALESPIB | PHASE1 | ClinicalTrials.gov | |
| NCT02612285 | SNX 5422 | PHASE2 | 2018-11-14 | ClinicalTrials.gov |
1 to 10 of 134
See all 134 trialsNIH grants2,477
NIH projects whose papers are about the gene, through NIH's grant-paper links.
| Project | Title | Its papers about the gene | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 38 | 2025 |
| ZIASC010074 | HSP90 and HSP70 Chaperone Proteins and Interactors in Cellular Signal Transduction | 21 | 2025 |
| ZIABC011032 | Post-translational modifications of Hsp90 | 17 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 10 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 10 | 2025 |
| R01NS059690 | Molecular Chaperones and Small Molecules | 9 | 2025 |
| R01AG067598 | Chaperome networks in Alzheimer's disease | 8 | 2025 |
| R01NS073899 | The hsp90 Cochaperone FKBP51 Regulates tau Structure and Function | 8 | 2025 |
| P30CA023074 | University of Arizona Cancer Center - Cancer Center Support Grant | 7 | 2025 |
| P30ES006694 | Southwest Environmental Health Sciences Center | 7 | 2025 |
1 to 10 of 2,477Source NIH's project files
See all 2,477 nih grantsPapers4,343
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| PMID | Found by | Source |
|---|---|---|
| 42822389 | PubTator, text mining | PubMed |
| 42799811 | PubTator, text mining | PubMed |
| 42793153 | PubTator, text mining | PubMed |
| 42764310 | PubTator, text mining | PubMed |
| 42758966 | PubTator, text mining | PubMed |
| 42758207 | PubTator, text mining | PubMed |
| 42757385 | PubTator, text mining | PubMed |
| 42700511 | PubTator, text mining | PubMed |
| 42675534 | PubTator, text mining | PubMed |
| 42675068 | PubTator, text mining | PubMed |
1 to 10 of 4,343
See all 4,343 papersSources 11
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNone stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GeneNone named. Public domain as US government information
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3326
GET https://conductscience.org/api/genes/v1/3326/patents?page=2