Gene · 3336
HSPE1: heat shock protein family E (Hsp10) member 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. HSPE1: heat shock protein family E (Hsp10) member 1. Genes, record 3336. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3336
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P61604 | 10 kDa heat shock protein, mitochondrial | 102 | 16 | Ensembl, GeneID, HGNC |
Source UniProt
Patents99
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 48713 | P61604 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 869 | P61604 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4387 | P61604 | Espacenet |
| EP 4582098 A2 | 2025-07-09 | 1367 | P61604 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 869 | P61604 | Espacenet |
| JP 2025038035 A | 2025-03-18 | 4384 | P61604 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 4387 | P61604 | Espacenet |
| US 12134655 B2 | 2024-11-05 | 4384 | P61604 | Espacenet |
| US 11860162 B2 | 2024-01-02 | 1432 | P61604 | Espacenet |
| KR 1020230155484 A | 2023-11-10 | 24 | P61604 | Espacenet |
1 to 10 of 99
See all 99 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,499
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | HSPE1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 9 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 8 | 2025 |
| P30ES006694 | Southwest Environmental Health Sciences Center | 8 | 2025 |
| P30CA023074 | University of Arizona Cancer Center - Cancer Center Support Grant | 5 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 4 | 2025 |
| ZIADK029023 | Structure and Dynamics Of Macromolecules In Solution By NMR | 4 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 3 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 3 | 2025 |
| P40OD010440 | Caenorhabditis Genetics Center | 3 | 2025 |
1 to 10 of 1,499Source NIH's project files
See all 1,499 nih grantsPapers3,463
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| HSP60 and HSP10 depletion provoke distinct biological responses. | Philos Trans R Soc Lond B Biol Sci | 2026 | 42817641 | PubTator, text mining | PubMed |
| The mitochondrial chaperone HSPD1 folds MTHFD2 independently of its co-chaperone HSPE1. | Philos Trans R Soc Lond B Biol Sci | 2026 | 42817635 | PubTator, text mining | PubMed |
| Proteomic remodeling of outer membrane vesicles in antibiotic-resistant Helicobacter pylori reveals adaptive stress responses. | Front Microbiol | 2026 | 42761125 | PubTator, text mining | PubMed |
| Integrative TWAS and multi-omics analyses prioritize HSPE1 as a candidate risk gene for bipolar disorder with immune cell-specific regulatory evidence. | Eur Arch Psychiatry Clin Neurosci | 2026 | 42608581 | PubTator, text mining | PubMed |
| Structural interplay of the redox co-chaperone CnoX to GroEL/ES chaperonin. | Life Sci Alliance | 2026 | 42567683 | PubTator, text mining | PubMed |
| Repurposing drugs for treating dengue haemorrhagic fever and associated autoimmune diseases. | In Silico Pharmacol | 2026 | 42542660 | PubTator, text mining | PubMed |
| Ketogenic β-hydroxybutyrate-regulated β-hydroxybutyrylation of HSPE1 alleviates neuronal apoptosis in MPTP/MPP+ induced Parkinson's disease models. | Food Funct | 2026 | 42455758 | PubTator, text mining | PubMed |
| Neuroinflammation- molecular target based therapeutic approach. | Adv Protein Chem Struct Biol | 2026 | 42448410 | PubTator, text mining | PubMed |
| HSPE1 promotes immune evasion in lung adenocarcinoma by mediating mitochondrial oxidative stress via histone lactylation-mediated SDHA transcriptional activation. | Transl Oncol | 2026 | 42447569 | PubTator, text mining | PubMed |
| Mitochondrial Hsp60/10 Client Protein Decline Reveals Braak/Tau- and Cognition-Linked Proteostasis Vulnerabilities in Alzheimer's Disease. | bioRxiv | 2026 | 42427702 | PubTator, text mining | PubMed |
1 to 10 of 3,463
See all 3,463 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3336
GET https://conductscience.org/api/genes/v1/3336/patents?page=2