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Gene · 3336

HSPE1: heat shock protein family E (Hsp10) member 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HSPE1: heat shock protein family E (Hsp10) member 1. Genes, record 3336. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3336

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Gene

Symbol
HSPE1
HGNC
Name
heat shock protein family E (Hsp10) member 1
HGNC
NCBI Gene ID
3336
NCBI Gene
HGNC ID
HGNC:5269
HGNC
Ensembl
ENSG00000115541
NCBI Gene
Aliases
CPN10, EPF, GROES, GroES, HSP10
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P6160410 kDa heat shock protein, mitochondrial10216Ensembl, GeneID, HGNC

Source UniProt

Patents99

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448713P61604Espacenet
EP 4650780 A22025-11-19869P61604Espacenet
EP 4641202 A22025-10-294387P61604Espacenet
EP 4582098 A22025-07-091367P61604Espacenet
JP 2025517970 A2025-06-12869P61604Espacenet
JP 2025038035 A2025-03-184384P61604Espacenet
KR 1020250017231 A2025-02-044387P61604Espacenet
US 12134655 B22024-11-054384P61604Espacenet
US 11860162 B22024-01-021432P61604Espacenet
KR 1020230155484 A2023-11-1024P61604Espacenet

1 to 10 of 99

See all 99 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,499

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHSPE1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant92025
P30CA016056Roswell Park Cancer Center Support Grant82025
P30ES006694Southwest Environmental Health Sciences Center82025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant52025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center42025
ZIADK029023Structure and Dynamics Of Macromolecules In Solution By NMR42025
P30CA016087Cancer Center Support Grant32025
P30CA016672Cancer Center Support Grant32025
P30CA021765Cancer Center Support Grant (CCSG)32025
P40OD010440Caenorhabditis Genetics Center32025

1 to 10 of 1,499Source NIH's project files

See all 1,499 nih grants

Papers3,463

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
HSP60 and HSP10 depletion provoke distinct biological responses.Philos Trans R Soc Lond B Biol Sci202642817641PubTator, text miningPubMed
The mitochondrial chaperone HSPD1 folds MTHFD2 independently of its co-chaperone HSPE1.Philos Trans R Soc Lond B Biol Sci202642817635PubTator, text miningPubMed
Proteomic remodeling of outer membrane vesicles in antibiotic-resistant Helicobacter pylori reveals adaptive stress responses.Front Microbiol202642761125PubTator, text miningPubMed
Integrative TWAS and multi-omics analyses prioritize HSPE1 as a candidate risk gene for bipolar disorder with immune cell-specific regulatory evidence.Eur Arch Psychiatry Clin Neurosci202642608581PubTator, text miningPubMed
Structural interplay of the redox co-chaperone CnoX to GroEL/ES chaperonin.Life Sci Alliance202642567683PubTator, text miningPubMed
Repurposing drugs for treating dengue haemorrhagic fever and associated autoimmune diseases.In Silico Pharmacol202642542660PubTator, text miningPubMed
Ketogenic β-hydroxybutyrate-regulated β-hydroxybutyrylation of HSPE1 alleviates neuronal apoptosis in MPTP/MPP+ induced Parkinson's disease models.Food Funct202642455758PubTator, text miningPubMed
Neuroinflammation- molecular target based therapeutic approach.Adv Protein Chem Struct Biol202642448410PubTator, text miningPubMed
HSPE1 promotes immune evasion in lung adenocarcinoma by mediating mitochondrial oxidative stress via histone lactylation-mediated SDHA transcriptional activation.Transl Oncol202642447569PubTator, text miningPubMed
Mitochondrial Hsp60/10 Client Protein Decline Reveals Braak/Tau- and Cognition-Linked Proteostasis Vulnerabilities in Alzheimer's Disease.bioRxiv202642427702PubTator, text miningPubMed

1 to 10 of 3,463

See all 3,463 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3336

GET https://conductscience.org/api/genes/v1/3336/patents?page=2