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Gene · 3337

DNAJB1: DnaJ heat shock protein family (Hsp40) member B1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DNAJB1: DnaJ heat shock protein family (Hsp40) member B1. Genes, record 3337. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3337

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Gene

Symbol
DNAJB1
HGNC
Name
DnaJ heat shock protein family (Hsp40) member B1
HGNC
NCBI Gene ID
3337
NCBI Gene
HGNC ID
HGNC:5270
HGNC
Ensembl
ENSG00000132002
NCBI Gene
Aliases
HSPF1, Hdj1, Hsp40, RSPH16B, Sis1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P25685DnaJ homolog subfamily B member 134015Ensembl, GeneID, HGNC

Source UniProt

Patents77

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026120675 A2026-07-22779P25685Espacenet
JP 2026004568 A2026-01-1444097P25685Espacenet
EP 4650780 A22025-11-191489P25685Espacenet
EP 4641202 A22025-10-294468P25685Espacenet
JP 2025517970 A2025-06-121489P25685Espacenet
JP 2025032204 A2025-03-1127364P25685Espacenet
KR 1020250020708 A2025-02-1116P25685Espacenet
KR 1020250017231 A2025-02-044468P25685Espacenet
JP 2024167327 A2024-12-0316P25685Espacenet
EP 4461818 A22024-11-1327364P25685Espacenet

1 to 10 of 77

See all 77 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,534

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDNAJB1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant242025
P50CA210964Mayo Clinic Hepatobiliary SPORE162025
P30CA016672Cancer Center Support Grant122025
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success122025
R01NS059690Molecular Chaperones and Small Molecules112025
R15GM110606J-Protein Regulation of Yeast Prion Propagation92025
R01AR068797Chaperone Dysfunction in Myopathy: Connecting Yeast Genetics with Mouse Models72025
R35GM130389Lessons Learned from PKA: Assembly of Dynamic Macromolecular Switches62025
ZIADK024950Prions of Yeast and Anti-Prion Systems62025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control52025

1 to 10 of 1,534Source NIH's project files

See all 1,534 nih grants

Papers2,173

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Multi-Omics Analysis and Experimental Validation Uncover Neddylation-Associated Biomarkers and Cellular Landscape in Lung Adenocarcinoma.Front Biosci (Landmark Ed)202642811976PubTator, text miningPubMed
Detection of Low Levels of DNAJB1::PRKACA Fusion KinaseRequires the Utilization of Sensitive Assays and CarefulMethodological Planning. Reply to Palaz et al. Independent Multi-Cohort RNA-Seq Analysis Does Not Support Recurrent DNAJB1::PRKACA Fusion in Hepatoblastoma or Biliary Atresia. Comment on "Fleifil et al. DNAJB1-PKAc Kinase Is Expressed in Young Patients with Pediatric Liver Cancers and Enhances Carcinogenic Pathways. Cancers 2025, 17, 83".
Cancers (Basel)202642650017PubTator, text miningPubMed
Independent Multi-Cohort RNA-Seq Analysis Does Not Support Recurrent DNAJB1::PRKACA Fusion in Hepatoblastoma or Biliary Atresia. Comment on Fleifil et al. DNAJB1-PKAc Kinase Is Expressed in Young Patients with Pediatric Liver Cancers and Enhances Carcinogenic Pathways. Cancers 2025, 17, 83.
Cancers (Basel)202642649992PubTator, text miningPubMed
Management of rare primary liver cancers: combined hepato-cholangiocarcinoma and fibrolamellar hepatocellular carcinoma.JHEP Rep202642595050PubTator, text miningPubMed
Novel Insights into the Human Hsc70 Structure by Cross-Linking Mass Spectrometry and Molecular Modeling.J Proteome Res202642565729PubTator, text miningPubMed
Single-cell RNA sequencing reveals immunological heterogeneity of the tumor microenvironment in acute myeloid leukemia.Adv Clin Exp Med202642524819PubTator, text miningPubMed
Dynamic m6A epitranscriptomic remodeling coordinates host transcriptional reprogramming during MPXV infection.Cell Commun Signal202642469869PubTator, text miningPubMed
Discovery of hub genes linking oxidative stress to type 2 diabetic sarcopenia using single-cell sequencing and machine learning.PLoS One202642412755PubTator, text miningPubMed
Functional Precision Oncology in Fibrolamellar Carcinoma: Ex Vivo Identification of Therapeutic Vulnerabilities.Cancers (Basel)202642279327PubTator, text miningPubMed
Human J-domain proteins promote stress granule disassembly and suppress neurodegeneration-linked protein aggregation.Cell Rep202642262924PubTator, text miningPubMed

1 to 10 of 2,173

See all 2,173 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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