ConductScience.org, home

Library / Genes

HTR1A: 5-hydroxytryptamine receptor 1A

1 protein, 33 patents, 38 drugs, 613 trials, 3,699 NIH grants and 9,087 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHTR1AHGNC
Name5-hydroxytryptamine receptor 1AHGNC
NCBI Gene ID3350NCBI Gene
HGNC IDHGNC:5286HGNC
EnsemblENSG00000178394NCBI Gene
Aliases5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCDNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P089085-hydroxytryptamine receptor 1A42230Ensembl, GeneID, HGNCUniProt

Patents 33

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062654 A2026-04-1047P08908Espacenet
US 12560619 B22026-02-2491P08908Espacenet
JP 2026004568 A2026-01-1435749P08908Espacenet
JP 2025529142 A2025-09-042000P08908Espacenet
US 12371689 B22025-07-292000P08908Espacenet
JP 2025062604 A2025-04-14388P08908Espacenet
US 12038446 B22024-07-1691P08908Espacenet
JP 2023156353 A2023-10-2447P08908Espacenet
JP 2023519296 A2023-05-1039P08908Espacenet
US 11446398 B22022-09-20388P08908Espacenet

Drugs 38

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ADOPRAZINECHEMBL221692Serotonin 1a (5-HT1a) receptor agonistAGONISTChEMBL
ALVERINECHEMBL253371Serotonin 1a (5-HT1a) receptor antagonistANTAGONISTChEMBL
AMISULPRIDECHEMBL243712Serotonin (5-HT) receptor antagonistANTAGONISTChEMBL
ARIPIPRAZOLECHEMBL1112Serotonin 1a (5-HT1a) receptor partial agonistPARTIAL AGONISTChEMBL
ARIPIPRAZOLE LAUROXILCHEMBL2219425Serotonin 1a (5-HT1a) receptor partial agonistPARTIAL AGONISTChEMBL
BEFIRADOLCHEMBL45305Serotonin 1a (5-HT1a) receptor agonistAGONISTChEMBL
BIFEPRUNOXCHEMBL218166Serotonin 1a (5-HT1a) receptor partial agonistPARTIAL AGONISTChEMBL
BREXPIPRAZOLECHEMBL2105760Serotonin 1a (5-HT1a) receptor partial agonistPARTIAL AGONISTChEMBL
BUSPIRONECHEMBL49Serotonin 1a (5-HT1a) receptor partial agonistPARTIAL AGONISTChEMBL
BUSPIRONE HYDROCHLORIDECHEMBL1200399Serotonin 1a (5-HT1a) receptor partial agonistPARTIAL AGONISTChEMBL

Trials 613

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07565428ARIPIPRAZOLEPHASE3ClinicalTrials.gov
NCT07547384ARIPIPRAZOLEClinicalTrials.gov
NCT07483294ARIPIPRAZOLEPHASE4ClinicalTrials.gov
NCT07439042BUSPIRONEPHASE4ClinicalTrials.gov
NCT07284628VORTIOXETINEPHASE2ClinicalTrials.gov
NCT07225712ULOTARONTPHASE3ClinicalTrials.gov
NCT07215884ARIPIPRAZOLEPHASE1ClinicalTrials.gov
NCT07204314VORTIOXETINEPHASE3ClinicalTrials.gov
NCT07153406ARIPIPRAZOLEPHASE3ClinicalTrials.gov
NCT07152184ARIPIPRAZOLEPHASE2ClinicalTrials.gov

NIH grants 3699

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIAMH002793PET Radiopharmaceutical Sciences192,025NIH's project files
T32MH015144Research Training in Mood and Anxiety Disorders: From Animal Models to Patients142,025NIH's project files
ZIAMH002795Translational Evaluation of PET Radiotracers132,025NIH's project files
P51OD011132Emory National Primate Research Center102,025NIH's project files
ZIAAA000301Integrative genetics of behavior with high throughput technologies102,025NIH's project files
ZIADA000424Novel Dopamine D3/D2 Receptor Ligands92,025NIH's project files
ZIAMH002852Clinical Evaluation of PET Radiotracers92,025NIH's project files
P51OD011092Support for National Primate Research Center82,025NIH's project files
T32MH018399Fellowship in Biological Psychiatry and Neuroscience82,025NIH's project files
P42ES010356Duke University Superfund Research Center - Developmental Co-Exposures: Mechanisms, Outcomes, and Remediation72,025NIH's project files

Papers 9087

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42817590PubTator, text miningPubMed
42809102PubTator, text miningPubMed
42782768PubTator, text miningPubMed
42729393PubTator, text miningPubMed
42716209PubTator, text miningPubMed
42653723PubTator, text miningPubMed
42641769PubTator, text miningPubMed
42639001PubTator, text miningPubMed
42624449PubTator, text miningPubMed
42621803PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license