ConductScience.org, home

Gene · 3351

HTR1B: 5-hydroxytryptamine receptor 1B

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. HTR1B: 5-hydroxytryptamine receptor 1B. Genes, record 3351. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3351

On this page

Gene

Symbol
HTR1B
HGNC
Name
5-hydroxytryptamine receptor 1B
HGNC
NCBI Gene ID
3351
NCBI Gene
HGNC ID
HGNC:5287
HGNC
Ensembl
ENSG00000135312
NCBI Gene
Aliases
5-HT-1B, 5-HT-1D-beta, 5-HT1B, 5-HT1DB, HTR1D2, HTR1DB, S12
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P282225-hydroxytryptamine receptor 1B3905Ensembl, GeneID, HGNC

Source UniProt

Patents38

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1435751P28222Espacenet
JP 2025529142 A2025-09-042001P28222Espacenet
US 12371689 B22025-07-292001P28222Espacenet
JP 2025062604 A2025-04-14390P28222Espacenet
JP 2025032204 A2025-03-1129768P28222Espacenet
EP 4461818 A22024-11-1329768P28222Espacenet
JP 2023153821 A2023-10-1843P28222Espacenet
JP 2023058610 A2023-04-2529768P28222Espacenet
US 11446398 B22022-09-20390P28222Espacenet
US 11407837 B22022-08-0943P28222Espacenet

1 to 10 of 38

See all 38 patents

Drugs25

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALMOTRIPTANCHEMBL1505Serotonin 1b (5-HT1b) receptor agonistAGONISTChEMBL
ALMOTRIPTAN MALATECHEMBL1200521Serotonin 1b (5-HT1b) receptor agonistAGONISTChEMBL
AMISULPRIDECHEMBL243712Serotonin (5-HT) receptor antagonistANTAGONISTChEMBL
DEXFENFLURAMINECHEMBL248702Serotonin (5-HT) receptor agonistAGONISTChEMBL
DEXFENFLURAMINE HYDROCHLORIDECHEMBL1887891Serotonin (5-HT) receptor agonistAGONISTChEMBL
DONITRIPTANCHEMBL1742428Serotonin 1b (5-HT1b) receptor agonistAGONISTChEMBL
ELETRIPTANCHEMBL1510Serotonin 1b (5-HT1b) receptor agonistAGONISTChEMBL
ELETRIPTAN HYDROBROMIDECHEMBL1201003Serotonin 1b (5-HT1b) receptor agonistAGONISTChEMBL
ELZASONANCHEMBL3185463Serotonin 1b (5-HT1b) receptor antagonistANTAGONISTChEMBL
ELZASONAN HYDROCHLORIDECHEMBL3989805Serotonin 1b (5-HT1b) receptor antagonistANTAGONISTChEMBL

1 to 10 of 25

See all 25 drugs

Trials184

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07152184AMISULPRIDEPHASE2ClinicalTrials.gov
NCT07103694SUMATRIPTANClinicalTrials.gov
NCT06887621AMISULPRIDEPHASE2ClinicalTrials.gov
NCT06868953SUMATRIPTANClinicalTrials.gov
NCT06677229ELETRIPTAN HYDROBROMIDEPHASE1/PHASE2ClinicalTrials.gov
NCT06585540AMISULPRIDEPHASE3ClinicalTrials.gov
NCT06581302AMISULPRIDEClinicalTrials.gov
NCT06503848SUMATRIPTANClinicalTrials.gov
NCT06473597RIZATRIPTAN BENZOATEPHASE4ClinicalTrials.gov
NCT06217094SUMATRIPTAN SUCCINATEPHASE1ClinicalTrials.gov

1 to 10 of 184

See all 184 trials

NIH grants1,709

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHTR1B papersNewest fiscal year
R01MH112205Molecular Details of Psychoactive Drug Actions82025
ZIAAA000301Integrative genetics of behavior with high throughput technologies82025
ZIAMH002793PET Radiopharmaceutical Sciences82025
UL1TR001863Yale Clinical and Translational Science Award52025
ZIAMH002795Translational Evaluation of PET Radiotracers52025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).42025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures42025
P30CA068485Cancer Center Support Grant32025
P50AA012870Center for the Translational Neuroscience of Alcoholism32025
R01EB026299BrainStorm: Highly Extensible Software for Advanced Electrophysiology and MEG/EEG Imaging32025

1 to 10 of 1,709Source NIH's project files

See all 1,709 nih grants

Papers2,771

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Cross-Platform Analysis of Endothelial Transcriptomic Changes Associated with Diabetes.Res Sq202642818903PubTator, text miningPubMed
Moving beyond 5-HT2A: language models map neurotransmitter receptors to experiential semantics.Psychopharmacology (Berl)202642809102PubTator, text miningPubMed
The influence of pharmacogenetics on the treatment-related outcomes of antidepressants and antipsychotics in Brazil: a systematic review.Pharmacogenomics202642740717PubTator, text miningPubMed
Differential Effects of Illness and Antipsychotics on Cortical Thinning in First-Episode Psychosis: A Randomized, Placebo-Controlled Magnetic Resonance Imaging Study.Biol Psychiatry202642690206PubTator, text miningPubMed
Associations between dopaminergic and serotonergic systems in individuals with cocaine use disorder: An exploratory analysis of [¹¹C]PHNO and [¹¹C]P943 PET imaging.Drug Alcohol Depend202642685387PubTator, text miningPubMed
Exercise-related changes in depressive symptoms and their association with anterior cingulate cortical thickness.Int J Clin Health Psychol202642604120PubTator, text miningPubMed
The Antidepressant Vortioxetine Potently Inhibits Cell Growth in Cultured Human Glioblastoma Cells Expressing 5-HT1B Serotonin Receptors.Cells202642587732PubTator, text miningPubMed
Targeting Gi/o-coupled GPCRs to inhibit nociceptors: Insights from the serotonin receptor Htr1b and triptans.Cell Rep Med202642532046PubTator, text miningPubMed
Unraveling the neurochemical basis of structure-function coupling in bipolar disorder: A multimodal data fusion analysis.J Affect Disord202642442672PubTator, text miningPubMed
Widespread synaptic density loss in schizophrenia follows molecular and network architecture.Mol Psychiatry202642350786PubTator, text miningPubMed

1 to 10 of 2,771

See all 2,771 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3351

GET https://conductscience.org/api/genes/v1/3351/patents?page=2