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Gene · 3355

HTR1F: 5-hydroxytryptamine receptor 1F

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HTR1F: 5-hydroxytryptamine receptor 1F. Genes, record 3355. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3355

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Gene

Symbol
HTR1F
HGNC
Name
5-hydroxytryptamine receptor 1F
HGNC
NCBI Gene ID
3355
NCBI Gene
HGNC ID
HGNC:5292
HGNC
Ensembl
ENSG00000179097
NCBI Gene
Aliases
5-HT-1F, 5-HT1F, 5HT6, HTR1EL, MR77
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P309395-hydroxytryptamine receptor 1F3663Ensembl, GeneID, HGNC

Source UniProt

Patents34

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1435756P30939Espacenet
EP 4641201 A22025-10-295073P30939Espacenet
JP 2025529142 A2025-09-042004P30939Espacenet
US 12371689 B22025-07-292004P30939Espacenet
JP 2025517969 A2025-06-125073P30939Espacenet
JP 2025062604 A2025-04-14393P30939Espacenet
US 11446398 B22022-09-20393P30939Espacenet
US 11400116 B22022-08-02299P30939Espacenet
JP 2022524081 A2022-04-27103364P30939Espacenet
US 11078247 B22021-08-035239P30939Espacenet

1 to 10 of 34

See all 34 patents

Drugs11

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALMOTRIPTANCHEMBL1505Serotonin 1f (5-HT1f) receptor agonistAGONISTChEMBL
ALMOTRIPTAN MALATECHEMBL1200521Serotonin 1f (5-HT1f) receptor agonistAGONISTChEMBL
AMISULPRIDECHEMBL243712Serotonin (5-HT) receptor antagonistANTAGONISTChEMBL
DEXFENFLURAMINECHEMBL248702Serotonin (5-HT) receptor agonistAGONISTChEMBL
DEXFENFLURAMINE HYDROCHLORIDECHEMBL1887891Serotonin (5-HT) receptor agonistAGONISTChEMBL
ELETRIPTANCHEMBL1510Serotonin 1f (5-HT1f) receptor agonistAGONISTChEMBL
ELETRIPTAN HYDROBROMIDECHEMBL1201003Serotonin 1f (5-HT1f) receptor agonistAGONISTChEMBL
LASMIDITANCHEMBL3039520Serotonin 1f (5-HT1f) receptor agonistAGONISTChEMBL
LASMIDITAN SUCCINATECHEMBL3039526Serotonin 1f (5-HT1f) receptor agonistAGONISTChEMBL
ZIMELDINECHEMBL37744Serotonin (5-HT) receptor antagonistANTAGONISTChEMBL

1 to 10 of 11

See all 11 drugs

Trials72

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants290

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHTR1F papersNewest fiscal year
I01BX0008515-HT Stimulation of Mitochondrial Biogenesis and Acute Kidney Injury22025
P30AG066509University of Washington Alzheimer's Disease Research Center22025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)22025
P30CA118100University of New Mexico Cancer Center Support Grant22025
DP1DA054343Epigenomic labeling of cells that drive drug abuse behavior12025
F30AG082394Boosting protein synthesis using antisense oligonucleotides to treat neurodegeneration12025
F30MH136688Antisense oligonucleotide-based upregulation of neurodevelopmental disorder gene MYT1L12025
K01EB032898Microstructure and connectivity modeling from the cortex to the spinal cord in Multiple Sclerosis12025
P20GM103430Rhode Island IDeA Network of Biomedical Research Excellence12025
P20GM103436IDeA Networks of Biomedical Research Excellence in Kentucky12025

1 to 10 of 290Source NIH's project files

See all 290 nih grants

Papers407

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Emerging pharmacological targets in migraine therapy: CGRP and beyond.Front Pharmacol202642781272PubTator, text miningPubMed
Mitochondria in Renal Ischemia-Reperfusion Injury: From Mechanisms to Therapeutics.Biomedicines202641751208PubTator, text miningPubMed
Monoaminergic Networks of Cognitive and Behavioral Symptoms in Early Parkinson's Disease.Mov Disord202641618568PubTator, text miningPubMed
Immune dysfunction contributes to comorbid depression in patients with multiple sclerosis.J Affect Disord202641605342PubTator, text miningPubMed
Antecedent enhancer activity predicts future susceptibility to seizures in mice.Nat Commun202641507153PubTator, text miningPubMed
RNA-Seq reveals flight-induced changes in cerebellar transcriptomic profiles of racing pigeons.Genomics202641475467PubTator, text miningPubMed
Structure-guided rational design of dual-target CGRP antagonist/5HT1F agonist therapeutics for migraine.Eur J Med Chem202641270648PubTator, text miningPubMed
Association of HTR1F with Prognosis, Tumor Immune Microenvironment, and Drug Sensitivity in Cancer: A Multi-Omics Perspective.Biomedicines202541007799PubTator, text miningPubMed
Exploring the epigenetic modifications of the RONS-TRPA1-CGRP axis in migraine pathophysiology.J Headache Pain202540890590PubTator, text miningPubMed
Comparison of the effectiveness of first-line preventive treatment of migraine in primary care: study protocol for a pragmatic clinical trial (PREMI study).Trials202540859286PubTator, text miningPubMed

1 to 10 of 407

See all 407 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3355

GET https://conductscience.org/api/genes/v1/3355/patents?page=2