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Gene · 3357

HTR2B: 5-hydroxytryptamine receptor 2B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HTR2B: 5-hydroxytryptamine receptor 2B. Genes, record 3357. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3357

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Gene

Symbol
HTR2B
HGNC
Name
5-hydroxytryptamine receptor 2B
HGNC
NCBI Gene ID
3357
NCBI Gene
HGNC ID
HGNC:5294
HGNC
Ensembl
ENSG00000135914
NCBI Gene
Aliases
5-HT(2B), 5-HT-2B, 5-HT2B
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P415955-hydroxytryptamine receptor 2B48112Ensembl, GeneID, HGNC

Source UniProt

Patents48

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062654 A2026-04-1049P41595Espacenet
JP 2026004568 A2026-01-1435760P41595Espacenet
EP 4641201 A22025-10-291290P41595Espacenet
EP 4641202 A22025-10-2971P41595Espacenet
JP 2025529142 A2025-09-042006P41595Espacenet
US 12371689 B22025-07-292006P41595Espacenet
JP 2025517969 A2025-06-121290P41595Espacenet
JP 2025062604 A2025-04-14398P41595Espacenet
KR 1020250017231 A2025-02-0471P41595Espacenet
JP 2025500034 A2025-01-073P41595Espacenet

1 to 10 of 48

See all 48 patents

Drugs16

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMISULPRIDECHEMBL243712Serotonin (5-HT) receptor antagonistANTAGONISTChEMBL
CLOTHIAPINECHEMBL304902Serotonin 2 (5-HT2) receptor antagonistANTAGONISTChEMBL
DEXFENFLURAMINECHEMBL248702Serotonin (5-HT) receptor agonistAGONISTChEMBL
DEXFENFLURAMINE HYDROCHLORIDECHEMBL1887891Serotonin (5-HT) receptor agonistAGONISTChEMBL
METHYLERGONOVINECHEMBL1201356Serotonin 2b (5-HT2b) receptor partial agonistPARTIAL AGONISTChEMBL
METHYLERGONOVINE MALEATECHEMBL1200843Serotonin 2b (5-HT2b) receptor partial agonistPARTIAL AGONISTChEMBL
METHYSERGIDECHEMBL1065Serotonin 2b (5-HT2b) receptor antagonistANTAGONISTChEMBL
METHYSERGIDE MALEATECHEMBL1200938Serotonin 2b (5-HT2b) receptor antagonistANTAGONISTChEMBL
MINAPRINECHEMBL278819Serotonin 2 (5-HT2) receptor antagonistANTAGONISTChEMBL
MINAPRINE HYDROCHLORIDECHEMBL1364551Serotonin 2 (5-HT2) receptor antagonistANTAGONISTChEMBL

1 to 10 of 16

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Trials45

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

1 to 10 of 45

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NIH grants1,397

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHTR2B papersNewest fiscal year
R01MH112205Molecular Details of Psychoactive Drug Actions132025
ZIAAA000301Integrative genetics of behavior with high throughput technologies132025
ZIADA000522Preclinical medication development for stimulant use disorder92025
R35GM122481Development and Testing of New Computational Methods for Ligand Discovery and Mechanism82025
R37DA045657Mechanistic insights into LSD actions at 5-HT2A serotonin receptors72025
ZIADK031126Computer Modeling of G Protein-Coupled Receptors72025
ZIADK031117Development of Drugs Acting at Adenosine Receptors62025
ZIAMH002793PET Radiopharmaceutical Sciences52025
P30CA016086Cancer Center Support Grant42025
P30EY014801Miami Center for Vision Research42025

1 to 10 of 1,397Source NIH's project files

See all 1,397 nih grants

Papers2,210

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Deciphering the allosteric landscape of 5-HT2 receptors: integrated molecular dynamics and fragment molecular orbital analyses of activation mechanisms.Pharmacol Rep202642789242PubTator, text miningPubMed
Mechanisms of Serotonergic Modulation of Glial Cell Functions in the Recovery Period After Spinal Cord Injury.Cells202642782768PubTator, text miningPubMed
Integrative multi-omics analysis prioritizes compartment-specific candidate targets of gut microbiota metabolites in diabetic kidney disease.Front Immunol202642756821PubTator, text miningPubMed
Pharmacological Activity of Motugivatrep, a Novel Antagonist of Transient Receptor Potential Cation Channel Subfamily V Member 1.Biol Pharm Bull202642749621PubTator, text miningPubMed
Propofol alleviates OGD/R-induced cerebral ischemia-reperfusion injury-related neuronal injury by regulating NEDD4L-mediated ubiquitination of HTR2B.Biochem Biophys Res Commun202642748874PubTator, text miningPubMed
Can docking-score differences support 5-HT2A/5-HT2B subtype-selectivity decisions? An audited paired benchmark.In Silico Pharmacol202642707358PubTator, text miningPubMed
Mechanosensing channels PIEZO1 and PIEZO2 regulate mitral valve serotonin-mediated homeostasis and pathophysiology.Cardiovasc Res202642687771PubTator, text miningPubMed
Cardiovascular safety of psilocybin in psychiatric practice: a narrative review.Eur J Clin Pharmacol202642538465PubTator, text miningPubMed
Perioperative Esmolol Is Associated with Early Opioid Sparing in Patients with Ischemic Heart Disease: Evidence from a Retrospective Cohort and an Incisional Pain Rat Model.Curr Med Sci202642490018PubTator, text miningPubMed
Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development.Epilepsia202642470359PubTator, text miningPubMed

1 to 10 of 2,210

See all 2,210 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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