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HTR2C: 5-hydroxytryptamine receptor 2C

1 protein, 17 patents, 50 drugs, 1,160 trials, 2,686 NIH grants and 4,945 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHTR2CHGNC
Name5-hydroxytryptamine receptor 2CHGNC
NCBI Gene ID3358NCBI Gene
HGNC IDHGNC:5295HGNC
EnsemblENSG00000147246NCBI Gene
Aliases5-HT1C, 5-HT2C, 5-HTR2C, 5HTR2C, HTR1CNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P283355-hydroxytryptamine receptor 2C4588Ensembl, GeneID, HGNCUniProt

Patents 17

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-292530P28335Espacenet
JP 2025517969 A2025-06-122530P28335Espacenet
JP 2025062604 A2025-04-14399P28335Espacenet
JP 2025062604 A2025-04-14401P28335Espacenet
JP 2025032204 A2025-03-1129773P28335Espacenet
JP 2025032204 A2025-03-1129774P28335Espacenet
EP 4461818 A22024-11-1329773P28335Espacenet
EP 4461818 A22024-11-1329774P28335Espacenet
JP 2023058610 A2023-04-2529773P28335Espacenet
JP 2023058610 A2023-04-2529774P28335Espacenet

Drugs 50

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AGOMELATINECHEMBL10878Serotonin 2c (5-HT2c) receptor antagonistANTAGONISTChEMBL
AMISULPRIDECHEMBL243712Serotonin (5-HT) receptor antagonistANTAGONISTChEMBL
CARPHENAZINECHEMBL1201328Serotonin 2c (5-HT2c) receptor antagonistANTAGONISTChEMBL
CARPHENAZINE MALEATECHEMBL2358147Serotonin 2c (5-HT2c) receptor antagonistANTAGONISTChEMBL
CHLORPROTHIXENECHEMBL908Serotonin 2c (5-HT2c) receptor antagonistANTAGONISTChEMBL
CLOTHIAPINECHEMBL304902Serotonin 2 (5-HT2) receptor antagonistANTAGONISTChEMBL
CYCLOBENZAPRINECHEMBL669Serotonin 2c (5-HT2c) receptor antagonistANTAGONISTChEMBL
CYCLOBENZAPRINE HYDROCHLORIDECHEMBL1200636Serotonin 2c (5-HT2c) receptor antagonistANTAGONISTChEMBL
DEXFENFLURAMINECHEMBL248702Serotonin (5-HT) receptor agonistAGONISTChEMBL
DEXFENFLURAMINE HYDROCHLORIDECHEMBL1887891Serotonin (5-HT) receptor agonistAGONISTChEMBL

Trials 1160

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07575516RISPERIDONEPHASE2ClinicalTrials.gov
NCT07565428OLANZAPINEPHASE3ClinicalTrials.gov
NCT07565428RISPERIDONEPHASE3ClinicalTrials.gov
NCT07555171FENFLURAMINEClinicalTrials.gov
NCT07541157RISPERIDONEClinicalTrials.gov
NCT07524868RISPERIDONEClinicalTrials.gov
NCT07523256RISPERIDONEClinicalTrials.gov
NCT07503444FENFLURAMINE HYDROCHLORIDEPHASE3ClinicalTrials.gov
NCT07503002RISPERIDONEPHASE1ClinicalTrials.gov
NCT07490353RISPERIDONEPHASE1ClinicalTrials.gov

NIH grants 2686

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
T32DA007287Translational Explorations in Substance Use Disorders142,025NIH's project files
R01DA0384465-HT2 Receptor Allosterism in Cocaine Use Disorder92,025NIH's project files
R01MH112205Molecular Details of Psychoactive Drug Actions92,025NIH's project files
P51OD011132Emory National Primate Research Center72,025NIH's project files
R37DA045657Mechanistic insights into LSD actions at 5-HT2A serotonin receptors72,025NIH's project files
ZIADA000522Preclinical medication development for stimulant use disorder72,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)62,025NIH's project files
R25MH077823Research Education for Future Physician-Scientists in Child Psychiatry62,025NIH's project files
ZIAAA000301Integrative genetics of behavior with high throughput technologies62,025NIH's project files
ZIAMH002793PET Radiopharmaceutical Sciences62,025NIH's project files

Papers 4945

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42811266PubTator, text miningPubMed
42789242PubTator, text miningPubMed
42755522PubTator, text miningPubMed
42602890PubTator, text miningPubMed
42540671PubTator, text miningPubMed
42515916PubTator, text miningPubMed
42480244PubTator, text miningPubMed
42470359PubTator, text miningPubMed
42461339PubTator, text miningPubMed
42440716PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license