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HTR3A: 5-hydroxytryptamine receptor 3A

1 protein, 37 patents, 30 drugs, 293 trials, 2,108 NIH grants and 5,282 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHTR3AHGNC
Name5-hydroxytryptamine receptor 3AHGNC
NCBI Gene ID3359NCBI Gene
HGNC IDHGNC:5297HGNC
EnsemblENSG00000166736NCBI Gene
Aliases5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P460985-hydroxytryptamine receptor 3A4784Ensembl, GeneID, HGNCUniProt

Patents 37

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1914770P46098Espacenet
EP 4641201 A22025-10-2917417P46098Espacenet
JP 2025529142 A2025-09-042008P46098Espacenet
US 12371689 B22025-07-292008P46098Espacenet
JP 2025517969 A2025-06-1217417P46098Espacenet
JP 2025517970 A2025-06-1214770P46098Espacenet
JP 2025062604 A2025-04-14406P46098Espacenet
US 11446398 B22022-09-20406P46098Espacenet
JP 2022524081 A2022-04-27103377P46098Espacenet
JP 2017121240 A2017-07-1348210P46098Espacenet

Drugs 30

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALOSETRONCHEMBL1110Serotonin 3a (5-HT3a) receptor antagonistANTAGONISTChEMBL
ALOSETRON HYDROCHLORIDECHEMBL1200885Serotonin 3a (5-HT3a) receptor antagonistANTAGONISTChEMBL
AMISULPRIDECHEMBL243712Serotonin (5-HT) receptor antagonistANTAGONISTChEMBL
CILANSETRONCHEMBL2103778Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL
CLOTHIAPINECHEMBL304902Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL
DEXFENFLURAMINECHEMBL248702Serotonin (5-HT) receptor agonistAGONISTChEMBL
DEXFENFLURAMINE HYDROCHLORIDECHEMBL1887891Serotonin (5-HT) receptor agonistAGONISTChEMBL
DOLASETRONCHEMBL2368925Serotonin 3a (5-HT3a) receptor antagonistANTAGONISTChEMBL
DOLASETRON MESYLATECHEMBL2368924Serotonin 3a (5-HT3a) receptor antagonistANTAGONISTChEMBL
FACINICLINECHEMBL2151439Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL

Trials 293

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07480785PALONOSETRONClinicalTrials.gov
NCT07284628VORTIOXETINEPHASE2ClinicalTrials.gov
NCT07204314VORTIOXETINEPHASE3ClinicalTrials.gov
NCT07201883ONDANSETRONPHASE1ClinicalTrials.gov
NCT07152184AMISULPRIDEPHASE2ClinicalTrials.gov
NCT06887621AMISULPRIDEPHASE2ClinicalTrials.gov
NCT06850740ONDANSETRONClinicalTrials.gov
NCT06810882ONDANSETRONClinicalTrials.gov
NCT06805266VORTIOXETINEPHASE4ClinicalTrials.gov
NCT06789614METOCLOPRAMIDEClinicalTrials.gov

NIH grants 2108

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01NS077114Probing the structure and function of the intracellular domain of cys-loop receptors102,025NIH's project files
P30DK084567Mayo Center for Cell Signaling in Gastroenterology72,025NIH's project files
P60AA007611Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol72,025NIH's project files
ZIAAA000407Synaptic Transmission: Modulation, Plasticity And Effects Of Drugs Of Abuse72,025NIH's project files
ZIAES090089Modulation Of Neuronal Channels and Receptors in the Brain72,025NIH's project files
ZIAMH002793PET Radiopharmaceutical Sciences72,025NIH's project files
P30CA016672Cancer Center Support Grant62,025NIH's project files
T32AA007462Training Grant on Genetic Aspects of Alcoholism62,025NIH's project files
ZIAAA000301Integrative genetics of behavior with high throughput technologies62,025NIH's project files
P30CA008748Cancer Center Support Grant52,025NIH's project files

Papers 5282

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821156PubTator, text miningPubMed
42810428PubTator, text miningPubMed
42705228PubTator, text miningPubMed
42592880PubTator, text miningPubMed
42310370PubTator, text miningPubMed
42205501PubTator, text miningPubMed
42156686PubTator, text miningPubMed
42134555PubTator, text miningPubMed
42119640PubTator, text miningPubMed
42099156PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license