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Gene · 3362

HTR6: 5-hydroxytryptamine receptor 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HTR6: 5-hydroxytryptamine receptor 6. Genes, record 3362. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3362

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Gene

Symbol
HTR6
HGNC
Name
5-hydroxytryptamine receptor 6
HGNC
NCBI Gene ID
3362
NCBI Gene
HGNC ID
HGNC:5301
HGNC
Ensembl
ENSG00000158748
NCBI Gene
Aliases
5-HT6, 5-HT6R
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P504065-hydroxytryptamine receptor 64403Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1435789P50406Espacenet
JP 2025529142 A2025-09-042015P50406Espacenet
US 12371689 B22025-07-292015P50406Espacenet
JP 2025062604 A2025-04-14434P50406Espacenet
JP 2023153821 A2023-10-1838P50406Espacenet
JP 2023515708 A2023-04-1317P50406Espacenet
US 11446398 B22022-09-20434P50406Espacenet
US 11407837 B22022-08-0938P50406Espacenet
US 11400116 B22022-08-02304P50406Espacenet
JP 2022524081 A2022-04-27103405P50406Espacenet

1 to 10 of 26

See all 26 patents

Drugs10

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMISULPRIDECHEMBL243712Serotonin (5-HT) receptor antagonistANTAGONISTChEMBL
CERLAPIRDINECHEMBL2103880Serotonin 6 (5-HT6) receptor antagonistANTAGONISTChEMBL
DEXFENFLURAMINECHEMBL248702Serotonin (5-HT) receptor agonistAGONISTChEMBL
DEXFENFLURAMINE HYDROCHLORIDECHEMBL1887891Serotonin (5-HT) receptor agonistAGONISTChEMBL
IDALOPIRDINECHEMBL3286580Serotonin 6 (5-HT6) receptor antagonistANTAGONISTChEMBL
INTEPIRDINECHEMBL1083390Serotonin 6 (5-HT6) receptor antagonistANTAGONISTChEMBL
MASUPIRDINECHEMBL4117187Serotonin 6 (5-HT6) receptor antagonistANTAGONISTChEMBL
PF-05212377CHEMBL3329435Serotonin 6 (5-HT6) receptor antagonistANTAGONISTChEMBL
ZIMELDINECHEMBL37744Serotonin (5-HT) receptor antagonistANTAGONISTChEMBL
ZIMELDINE HYDROCHLORIDECHEMBL2355333Serotonin (5-HT) receptor antagonistANTAGONISTChEMBL

Trials62

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

1 to 10 of 62

See all 62 trials

NIH grants697

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHTR6 papersNewest fiscal year
P20GM109025Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) CNTN - Resubmission72025
UL1TR001863Yale Clinical and Translational Science Award52025
ZIAMH002793PET Radiopharmaceutical Sciences52025
ZIAMH002795Translational Evaluation of PET Radiotracers32025
P30AI050409Center for AIDS Research at Emory University22025
P30DK020579Diabetes Research Center22025
P30ES019776HERCULES: Exposome Research Center22025
R01DA0384465-HT2 Receptor Allosterism in Cocaine Use Disorder22025
R01EB026299BrainStorm: Highly Extensible Software for Advanced Electrophysiology and MEG/EEG Imaging22025
T32DA007287Translational Explorations in Substance Use Disorders22025

1 to 10 of 697Source NIH's project files

See all 697 nih grants

Papers1,299

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Multi-molecular adaptations of long-term opioid use in chronic pain.Brain202642817590PubTator, text miningPubMed
Comparative analysis of striatal subregions in behavioral variant frontotemporal dementia and late-life schizophrenia: A multimodal MRI study.Int Psychogeriatr202642722600PubTator, text miningPubMed
Multitarget interactions of bisphenol A in polycystic ovary syndrome: evidence from integrated network toxicology, mendelian randomization, and molecular docking.F S Sci202642386029PubTator, text miningPubMed
Association of Polymorphisms in Genes Involved in Serotonergic Signaling with the Risk of Developing Alzheimer's Disease.Curr Alzheimer Res202642316566PubTator, text miningPubMed
Primary cilia and neural computation.J Biomed Sci202642231312PubTator, text miningPubMed
Benzazepines Derivatives: Synthetic Strategy, Structural-Activity Relationships, and Medical Potential as Dopamine and Serotonin Receptor Modulators.ACS Omega202642179638PubTator, text miningPubMed
New chalcogen-optimized 1,3,5-triazines as dual 5-HT6R/FAAH modulators: A versatile approach to neurodegenerative disorders.Eur J Med Chem202642166820PubTator, text miningPubMed
Serotonergic Regulation of Nicotine Addiction: Receptor-specific Mechanisms and Therapeutic Strategies.Curr Neurovasc Res202642099156PubTator, text miningPubMed
Dually Acting Ligands Targeting Serotonin Receptors: Implications in CNS Disorders.J Med Chem202642044264PubTator, text miningPubMed
Receptor subtype distribution from PET occupancy studies: Novel analysis of maximum occupancy images using a selective drug and a non-selective tracer.J Cereb Blood Flow Metab202641944349PubTator, text miningPubMed

1 to 10 of 1,299

See all 1,299 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3362

GET https://conductscience.org/api/genes/v1/3362/patents?page=2