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Gene · 3363

HTR7: 5-hydroxytryptamine receptor 7

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HTR7: 5-hydroxytryptamine receptor 7. Genes, record 3363. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3363

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Gene

Symbol
HTR7
HGNC
Name
5-hydroxytryptamine receptor 7
HGNC
NCBI Gene ID
3363
NCBI Gene
HGNC ID
HGNC:5302
HGNC
Ensembl
ENSG00000148680
NCBI Gene
Aliases
5-HT7
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P349695-hydroxytryptamine receptor 74791Ensembl, GeneID, HGNC

Source UniProt

Patents21

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1435791P34969Espacenet
JP 2025529142 A2025-09-042016P34969Espacenet
US 12371689 B22025-07-292016P34969Espacenet
JP 2025062604 A2025-04-14436P34969Espacenet
JP 2025500034 A2025-01-072P34969Espacenet
JP 2024546484 A2024-12-242P34969Espacenet
EP 4444298 A22024-10-162P34969Espacenet
EP 4444718 A22024-10-162P34969Espacenet
KR 1020240133794 A2024-09-042P34969Espacenet
KR 1020230056435 A2023-04-271P34969Espacenet

1 to 10 of 21

See all 21 patents

Drugs8

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMISULPRIDECHEMBL243712Serotonin (5-HT) receptor antagonistANTAGONISTChEMBL
DEXFENFLURAMINECHEMBL248702Serotonin (5-HT) receptor agonistAGONISTChEMBL
DEXFENFLURAMINE HYDROCHLORIDECHEMBL1887891Serotonin (5-HT) receptor agonistAGONISTChEMBL
JNJ-18038683CHEMBL4297293Serotonin 7 (5-HT7) receptor antagonistANTAGONISTChEMBL
JNJ-18038683 FREE BASECHEMBL4205783Serotonin 7 (5-HT7) receptor antagonistANTAGONISTChEMBL
LY2590443CHEMBL3545220Serotonin 7 (5-HT7) receptor antagonistANTAGONISTChEMBL
ZIMELDINECHEMBL37744Serotonin (5-HT) receptor antagonistANTAGONISTChEMBL
ZIMELDINE HYDROCHLORIDECHEMBL2355333Serotonin (5-HT) receptor antagonistANTAGONISTChEMBL

Trials43

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

1 to 10 of 43

See all 43 trials

NIH grants885

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHTR7 papersNewest fiscal year
ZIAMH002793PET Radiopharmaceutical Sciences72025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).62025
ZIAMH002795Translational Evaluation of PET Radiotracers42025
P30CA008748Cancer Center Support Grant32025
R01GM088790Functional architecture of intracellular Ca2+ signals32025
R01MH112205Molecular Details of Psychoactive Drug Actions32025
P50AA012870Center for the Translational Neuroscience of Alcoholism22025
R25MH077823Research Education for Future Physician-Scientists in Child Psychiatry22025
R35GM122481Development and Testing of New Computational Methods for Ligand Discovery and Mechanism22025
T32DA031115Postdoctoral Training in Drug Abuse Research: Behavior & Neurobiology22025

1 to 10 of 885Source NIH's project files

See all 885 nih grants

Papers1,585

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The Antidepressant Vortioxetine Potently Inhibits Cell Growth in Cultured Human Glioblastoma Cells Expressing 5-HT1B Serotonin Receptors.Cells202642587732PubTator, text miningPubMed
Sodium Overload-Related Molecular Subtypes and a Four-Gene Prognostic Signature Predict Survival, Immune Landscape, and Therapeutic Response in Acute Myeloid Leukemia.Mol Carcinog202642541488PubTator, text miningPubMed
Jinhuang San alleviates plasma cell mastitis by restoring Th17/Treg balance through the HTR7/IL-6/JAK2/STAT3 axis.J Ethnopharmacol202642242601PubTator, text miningPubMed
Integrated analysis of miRNA and transcription factor gene expression profiles associated with anti-tuberculosis treatment responses.BMC Infect Dis202642237266PubTator, text miningPubMed
Brain Serotonin Deficiency Impairs Ovarian Reserve Function via the Hypothalamic-Pituitary-Ovarian Axis.Neurosci Bull202642184065PubTator, text miningPubMed
Serotonin Associated Mechanisms in Sudden Unexpected Death in Epilepsy: A Review.Rev Neurol202641914335PubTator, text miningPubMed
FTO-CHRM3 axis regulates multiple myeloma progression: a machine learning-based identification.Ann Hematol202641870649PubTator, text miningPubMed
Synthesis and biological evaluation of 1,3,5-triazine and 2-aminopyrimidine scaffolds as chemical probes targeting the 5-HT7-FOXM1 axis in triple-negative breast cancer.Eur J Med Chem202641844115PubTator, text miningPubMed
Advances in intratumoral immunotherapy from a neuro-immune-endocrine perspective for breast cancer treatment.Front Oncol202641800053PubTator, text miningPubMed
Neuroimmunological Mechanisms of Xiao-Yao-San Against Chronic Stress-Induced Colorectal Cancer: A Bioinformatics and Single-Cell Sequencing Study.Cancer Manag Res202641798904PubTator, text miningPubMed

1 to 10 of 1,585

See all 1,585 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3363

GET https://conductscience.org/api/genes/v1/3363/patents?page=2