Gene · 3363
HTR7: 5-hydroxytryptamine receptor 7
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. HTR7: 5-hydroxytryptamine receptor 7. Genes, record 3363. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3363
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P34969 | 5-hydroxytryptamine receptor 7 | 479 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents21
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 35791 | P34969 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2016 | P34969 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2016 | P34969 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 436 | P34969 | Espacenet |
| JP 2025500034 A | 2025-01-07 | 2 | P34969 | Espacenet |
| JP 2024546484 A | 2024-12-24 | 2 | P34969 | Espacenet |
| EP 4444298 A2 | 2024-10-16 | 2 | P34969 | Espacenet |
| EP 4444718 A2 | 2024-10-16 | 2 | P34969 | Espacenet |
| KR 1020240133794 A | 2024-09-04 | 2 | P34969 | Espacenet |
| KR 1020230056435 A | 2023-04-27 | 1 | P34969 | Espacenet |
1 to 10 of 21
See all 21 patentsDrugs8
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| AMISULPRIDE | CHEMBL243712 | Serotonin (5-HT) receptor antagonist | ANTAGONIST | ChEMBL |
| DEXFENFLURAMINE | CHEMBL248702 | Serotonin (5-HT) receptor agonist | AGONIST | ChEMBL |
| DEXFENFLURAMINE HYDROCHLORIDE | CHEMBL1887891 | Serotonin (5-HT) receptor agonist | AGONIST | ChEMBL |
| JNJ-18038683 | CHEMBL4297293 | Serotonin 7 (5-HT7) receptor antagonist | ANTAGONIST | ChEMBL |
| JNJ-18038683 FREE BASE | CHEMBL4205783 | Serotonin 7 (5-HT7) receptor antagonist | ANTAGONIST | ChEMBL |
| LY2590443 | CHEMBL3545220 | Serotonin 7 (5-HT7) receptor antagonist | ANTAGONIST | ChEMBL |
| ZIMELDINE | CHEMBL37744 | Serotonin (5-HT) receptor antagonist | ANTAGONIST | ChEMBL |
| ZIMELDINE HYDROCHLORIDE | CHEMBL2355333 | Serotonin (5-HT) receptor antagonist | ANTAGONIST | ChEMBL |
Trials43
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07152184 | AMISULPRIDE | PHASE2 | ClinicalTrials.gov | |
| NCT06887621 | AMISULPRIDE | PHASE2 | ClinicalTrials.gov | |
| NCT06585540 | AMISULPRIDE | PHASE3 | ClinicalTrials.gov | |
| NCT06581302 | AMISULPRIDE | ClinicalTrials.gov | ||
| NCT06040944 | AMISULPRIDE | ClinicalTrials.gov | ||
| NCT05956600 | AMISULPRIDE | ClinicalTrials.gov | ||
| NCT05347199 | AMISULPRIDE | PHASE1 | ClinicalTrials.gov | |
| NCT04954365 | AMISULPRIDE | ClinicalTrials.gov | ||
| NCT04533724 | AMISULPRIDE | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT04529226 | AMISULPRIDE | PHASE2 | ClinicalTrials.gov |
1 to 10 of 43
See all 43 trialsNIH grants885
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | HTR7 papers | Newest fiscal year |
|---|---|---|---|
| ZIAMH002793 | PET Radiopharmaceutical Sciences | 7 | 2025 |
| U10AA008401 | Collaborative Study on the Genetics of Alcoholism (COGA). | 6 | 2025 |
| ZIAMH002795 | Translational Evaluation of PET Radiotracers | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| R01GM088790 | Functional architecture of intracellular Ca2+ signals | 3 | 2025 |
| R01MH112205 | Molecular Details of Psychoactive Drug Actions | 3 | 2025 |
| P50AA012870 | Center for the Translational Neuroscience of Alcoholism | 2 | 2025 |
| R25MH077823 | Research Education for Future Physician-Scientists in Child Psychiatry | 2 | 2025 |
| R35GM122481 | Development and Testing of New Computational Methods for Ligand Discovery and Mechanism | 2 | 2025 |
| T32DA031115 | Postdoctoral Training in Drug Abuse Research: Behavior & Neurobiology | 2 | 2025 |
1 to 10 of 885Source NIH's project files
See all 885 nih grantsPapers1,585
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| The Antidepressant Vortioxetine Potently Inhibits Cell Growth in Cultured Human Glioblastoma Cells Expressing 5-HT1B Serotonin Receptors. | Cells | 2026 | 42587732 | PubTator, text mining | PubMed |
| Sodium Overload-Related Molecular Subtypes and a Four-Gene Prognostic Signature Predict Survival, Immune Landscape, and Therapeutic Response in Acute Myeloid Leukemia. | Mol Carcinog | 2026 | 42541488 | PubTator, text mining | PubMed |
| Jinhuang San alleviates plasma cell mastitis by restoring Th17/Treg balance through the HTR7/IL-6/JAK2/STAT3 axis. | J Ethnopharmacol | 2026 | 42242601 | PubTator, text mining | PubMed |
| Integrated analysis of miRNA and transcription factor gene expression profiles associated with anti-tuberculosis treatment responses. | BMC Infect Dis | 2026 | 42237266 | PubTator, text mining | PubMed |
| Brain Serotonin Deficiency Impairs Ovarian Reserve Function via the Hypothalamic-Pituitary-Ovarian Axis. | Neurosci Bull | 2026 | 42184065 | PubTator, text mining | PubMed |
| Serotonin Associated Mechanisms in Sudden Unexpected Death in Epilepsy: A Review. | Rev Neurol | 2026 | 41914335 | PubTator, text mining | PubMed |
| FTO-CHRM3 axis regulates multiple myeloma progression: a machine learning-based identification. | Ann Hematol | 2026 | 41870649 | PubTator, text mining | PubMed |
| Synthesis and biological evaluation of 1,3,5-triazine and 2-aminopyrimidine scaffolds as chemical probes targeting the 5-HT7-FOXM1 axis in triple-negative breast cancer. | Eur J Med Chem | 2026 | 41844115 | PubTator, text mining | PubMed |
| Advances in intratumoral immunotherapy from a neuro-immune-endocrine perspective for breast cancer treatment. | Front Oncol | 2026 | 41800053 | PubTator, text mining | PubMed |
| Neuroimmunological Mechanisms of Xiao-Yao-San Against Chronic Stress-Induced Colorectal Cancer: A Bioinformatics and Single-Cell Sequencing Study. | Cancer Manag Res | 2026 | 41798904 | PubTator, text mining | PubMed |
1 to 10 of 1,585
See all 1,585 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3363
GET https://conductscience.org/api/genes/v1/3363/patents?page=2