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Gene · 337

APOA4: apolipoprotein A4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. APOA4: apolipoprotein A4. Genes, record 337. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/337

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Gene

Symbol
APOA4
HGNC
Name
apolipoprotein A4
HGNC
NCBI Gene ID
337
NCBI Gene
HGNC ID
HGNC:602
HGNC
Ensembl
ENSG00000110244
NCBI Gene
Aliases
ADTKD6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P06727Apolipoprotein A-IV3962Ensembl, GeneID, HGNC

Source UniProt

Patents37

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1437645P06727Espacenet
EP 4650780 A22025-11-197480P06727Espacenet
EP 4640849 A22025-10-291115P06727Espacenet
EP 4641201 A22025-10-297453P06727Espacenet
JP 2025147176 A2025-10-06943P06727Espacenet
JP 2025519096 A2025-06-241115P06727Espacenet
JP 2025517969 A2025-06-127453P06727Espacenet
JP 2025517970 A2025-06-127480P06727Espacenet
JP 2025062604 A2025-04-145670P06727Espacenet
JP 2025028160 A2025-02-28943P06727Espacenet

1 to 10 of 37

See all 37 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,802

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAPOA4 papersNewest fiscal year
P30DK017047Diabetes Research Center122025
P01HL128203Multi-disciplinary Approaches to HDL Structure, Assembly, and Functional Heterogeneity72025
P30DK035816Nutrition Obesity Research Center62025
P30CA008748Cancer Center Support Grant52025
P30DK056341Washington University Nutrition Obesity Research Center52025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease52025
P01HL116263HDL Function in Human Disease42025
P01HL151328Triglycerides, Diabetes and Cardiovascular Disease42025
P30DK020572Michigan Diabetes Research Center (MDRC)42025
P50CA186781Mayo Clinic Multiple Myeloma SPORE42025

1 to 10 of 1,802Source NIH's project files

See all 1,802 nih grants

Papers3,283

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
From Machine Learning-Enhanced Proteomics to a Validated Diagnostic Model: A Pipeline for Breast Cancer Biomarker Discovery via Independent and Transcriptomic Corroboration.Bioengineering (Basel)202642791912PubTator, text miningPubMed
3 Discordant Extracardiac Amyloid Proteins Highlighting Bystander Deposition in a Case of Light-Chain Amyloid Cardiomyopathy.JACC Case Rep202642782045PubTator, text miningPubMed
Apolipoprotein A-IV Cardiac Amyloidosis as a Diagnostic Pitfall: Beyond the Noninvasive Algorithm.JACC Case Rep202642782043PubTator, text miningPubMed
Apolipoprotein A-IV Cardiac Amyloidosis: Beyond ATTR and AL.JACC Case Rep202642782041PubTator, text miningPubMed
Apolipoprotein A-IV Cardiac Amyloidosis Presenting as Massive Ventricular Wall Thickening Mimicking Hypertrophic Cardiomyopathy.JACC Case Rep202642782023PubTator, text miningPubMed
Clinical and Proteomic Biomarkers of Trifluridine/Tipiracil in Fluoropyrimidine-Refractory Advanced Pancreatic Adenocarcinoma: A Single-Arm Phase II Trial.JCO Precis Oncol202642777178PubTator, text miningPubMed
Dietary Patterns Are Key Predictors of Cardiovascular Risk Beyond Genetic Risk Across Metabolic Syndrome Trajectories in A Korean Prospective Cohort Study.J Nutr202642772683PubTator, text miningPubMed
Plasma Proteomic Profiling of Comorbid and Noncomorbid COVID-19 Patients in ICU.J Proteome Res202642695888PubTator, text miningPubMed
Plasma apolipoprotein A-IV deficiency as a proteomics-identified diagnostic biomarker for heat stroke: A prospective 2-center study.Chin J Traumatol202642557209PubTator, text miningPubMed
Proteomic analysis of corneal astigmatism identifies reduced apolipoprotein A-IV as a candidate biomarker.Front Med (Lausanne)202642529179PubTator, text miningPubMed

1 to 10 of 3,283

See all 3,283 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/337

GET https://conductscience.org/api/genes/v1/337/patents?page=2