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IAPP: islet amyloid polypeptide

1 protein, 149 patents, 0 drugs, 0 trials, 2,800 NIH grants and 6,754 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIAPPHGNC
Nameislet amyloid polypeptideHGNC
NCBI Gene ID3375NCBI Gene
HGNC IDHGNC:5329HGNC
EnsemblENSG00000121351NCBI Gene
AliasesAMYLIN, DAP, IAPNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P10997Islet amyloid polypeptide8978Ensembl, GeneID, HGNCUniProt

Patents 149

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4807368 A12026-09-163P10997Espacenet
EP 4727963 A22026-04-2247P10997Espacenet
WO 2026030354 A22026-02-0580P10997Espacenet
JP 2026004568 A2026-01-1450417P10997Espacenet
JP 2026004568 A2026-01-1450419P10997Espacenet
EP 4650780 A22025-11-191029P10997Espacenet
JP 2025147176 A2025-10-066676P10997Espacenet
JP 2025147176 A2025-10-066677P10997Espacenet
WO 2025199149 A12025-09-256019P10997Espacenet
JP 2025529142 A2025-09-046633P10997Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2800

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK017047Diabetes Research Center492,025NIH's project files
R01DK079895Structural mechanism of diabetic amyloid formation332,025NIH's project files
ZIABC010440Protein Structure, Stability, and Amyloid Formation182,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)162,025NIH's project files
T32DK007247Diabetes, Obesity and Metabolism Training Program152,025NIH's project files
P30DK020595Diabetes Research and Training Center142,025NIH's project files
P30DK020541NYR-Diabetes Research Center (NYR-DRC)132,025NIH's project files
P30DK036836Diabetes Research Center122,025NIH's project files
I01BX001060Pathogenesis and Impact of Islet Amyloid112,025NIH's project files
P30DK116073University of Colorado Anschutz Medical Campus DRC112,025NIH's project files

Papers 6754

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818175PubTator, text miningPubMed
42810355PubTator, text miningPubMed
42810353PubTator, text miningPubMed
42807762PubTator, text miningPubMed
42805778PubTator, text miningPubMed
42803913PubTator, text miningPubMed
42781272PubTator, text miningPubMed
42771080PubTator, text miningPubMed
42755650PubTator, text miningPubMed
42737853PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license