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Gene · 3376

IARS1: isoleucyl-tRNA synthetase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IARS1: isoleucyl-tRNA synthetase 1. Genes, record 3376. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3376

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Gene

Symbol
IARS1
HGNC
Name
isoleucyl-tRNA synthetase 1
HGNC
NCBI Gene ID
3376
NCBI Gene
HGNC ID
HGNC:5330
HGNC
Ensembl
ENSG00000196305
NCBI Gene
Aliases
GRIDHH, IARS, ILERS, ILRS, IRS, PRO0785
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P41252Isoleucine--tRNA ligase, cytoplasmic1,2620Ensembl, GeneID, HGNC

Source UniProt

Patents18

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1450442P41252Espacenet
JP 2026004568 A2026-01-1450446P41252Espacenet
EP 4641201 A22025-10-299918P41252Espacenet
JP 2025517969 A2025-06-129918P41252Espacenet
US 11446398 B22022-09-2042177P41252Espacenet
JP 2022524081 A2022-04-27145148P41252Espacenet
US 11078247 B22021-08-035272P41252Espacenet
JP 2019054813 A2019-04-11230877P41252Espacenet
JP 2019054813 A2019-04-11230881P41252Espacenet
JP 2017121241 A2017-07-13230877P41252Espacenet

1 to 10 of 18

See all 18 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,644

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIARS1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant82025
P30DK036836Diabetes Research Center72025
P30CA016672Cancer Center Support Grant62025
P30CA077598Cancer Center Support Grant62025
P50CA116201Mayo Clinic Breast Cancer SPORE62025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes52025
P30CA016086Cancer Center Support Grant52025
P30CA068485Cancer Center Support Grant52025
P30DK020572Michigan Diabetes Research Center (MDRC)52025
P30DK056341Washington University Nutrition Obesity Research Center52025

1 to 10 of 1,644Source NIH's project files

See all 1,644 nih grants

Papers2,904

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Transcriptomic Analysis of the Newborn Mammary Gland Identifies Prenatal Ethanol-Induced Remodeling of Insulin Signaling and Enhanced Proliferative Programming.bioRxiv202642818069PubTator, text miningPubMed
Beyond Translation Initiation: Translational Elongation, Decoding Fidelity, and Ribosome Surveillance During Branched-Chain Amino Acid Deprivation, with a Focus on Mammalian Systems.Biology (Basel)202642792574PubTator, text miningPubMed
Synthetic Studies Toward 2-Epi Altemicidin and Its Derivatives: Construction of the 6-Azatetrahydroindane Core.J Org Chem202642725948PubTator, text miningPubMed
Molecular characterization of mupirocin-resistant MRSA from Germany and South Africa.Front Cell Infect Microbiol202642643317PubTator, text miningPubMed
Connecting the dots between sleep deprivation and obesity: the role of melatonin in appetite regulation and insulin sensitivity from a mechanistic review perspective.Physiol Behav202642637185PubTator, text miningPubMed
Effects of folic acid on the IRS-PI3K-AKT pathway in an in vitro insulin resistance model.Placenta202642636773PubTator, text miningPubMed
Circadian Regulation of Glucose Metabolism: Implications for Pathogenesis and Chronotherapy of Type 2 Diabetes.Diabetology (Basel)202642583078PubTator, text miningPubMed
Regional heterogeneity of brain insulin resistance: From molecular pathways to neural circuits.Neurosci Biobehav Rev202642392464PubTator, text miningPubMed
Single-cell profiling of gastric cancer ascites reveals an epithelial-immune dual phenotype signature predictive for anti-PD-1 immunotherapy responses.BMC Med202642374437PubTator, text miningPubMed
Pannexin 1 attenuates hepatic steatosis and insulin resistance via AMPK-autophagy axis activation.Cell Mol Life Sci202642340400PubTator, text miningPubMed

1 to 10 of 2,904

See all 2,904 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3376

GET https://conductscience.org/api/genes/v1/3376/patents