ConductScience.org, home

Library / Genes

APOB: apolipoprotein B

1 protein, 20 patents, 2 drugs, 14 trials, 10,360 NIH grants and 39,935 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolAPOBHGNC
Nameapolipoprotein BHGNC
NCBI Gene ID338NCBI Gene
HGNC IDHGNC:603HGNC
EnsemblENSG00000084674NCBI Gene
AliasesApoB-100, FCHL2, FLDB, LDLCQ4, apoB-100, apoB-48NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P04114Apolipoprotein B-1004,5638Ensembl, GeneID, HGNCUniProt

Patents 20

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026070830 A2026-04-028P04114Espacenet
EP 4650780 A22025-11-19850P04114Espacenet
EP 4640849 A22025-10-2998P04114Espacenet
EP 4641201 A22025-10-29596P04114Espacenet
JP 2025147176 A2025-10-06947P04114Espacenet
WO 2025199298 A12025-09-2516P04114Espacenet
JP 2025519096 A2025-06-2498P04114Espacenet
JP 2025517969 A2025-06-12596P04114Espacenet
JP 2025517970 A2025-06-12850P04114Espacenet
JP 2025062604 A2025-04-145674P04114Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
MIPOMERSENCHEMBL2219536Apo-B 100 mRNA antisense inhibitorANTISENSE INHIBITORChEMBL
MIPOMERSEN SODIUMCHEMBL502097Apo-B 100 mRNA antisense inhibitorANTISENSE INHIBITORChEMBL

Trials 14

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01598948MIPOMERSENPHASE3ClinicalTrials.gov
NCT01475825MIPOMERSEN SODIUMPHASE32019-03-14ClinicalTrials.gov
NCT00794664MIPOMERSENPHASE32013-03-21ClinicalTrials.gov
NCT00770146MIPOMERSENPHASE32013-03-20ClinicalTrials.gov
NCT00707746MIPOMERSENPHASE22013-04-05ClinicalTrials.gov
NCT00706849MIPOMERSENPHASE32013-03-21ClinicalTrials.gov
NCT00694109MIPOMERSENPHASE32015-12-21ClinicalTrials.gov
NCT00607373MIPOMERSENPHASE32013-03-21ClinicalTrials.gov
NCT00477594MIPOMERSEN SODIUMPHASE22013-04-05ClinicalTrials.gov
NCT00362180MIPOMERSENPHASE22015-06-24ClinicalTrials.gov

NIH grants 10360

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK056341Washington University Nutrition Obesity Research Center832,025NIH's project files
P30DK017047Diabetes Research Center792,025NIH's project files
P30DK063491Diabetes Research Center (DRC)572,025NIH's project files
P30DK035816Nutrition Obesity Research Center472,025NIH's project files
P30DK052574Host-environment interactions in the pathophysiology of digestive disease412,025NIH's project files
P30CA008748Cancer Center Support Grant322,025NIH's project files
P01HL116263HDL Function in Human Disease312,025NIH's project files
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)312,025NIH's project files
R01HL142711Whole genome sequences in ethnically diverse individuals to comprehensively characterize the genetic mechanisms of dyslipidemias292,025NIH's project files
P30DK020541NYR-Diabetes Research Center (NYR-DRC)282,025NIH's project files

Papers 39935

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826815PubTator, text miningPubMed
42824094PubTator, text miningPubMed
42823272PubTator, text miningPubMed
42822582PubTator, text miningPubMed
42820892PubTator, text miningPubMed
42820004PubTator, text miningPubMed
42818356PubTator, text miningPubMed
42817005PubTator, text miningPubMed
42814261PubTator, text miningPubMed
42812427PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license