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Gene · 338442

HCAR2: hydroxycarboxylic acid receptor 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HCAR2: hydroxycarboxylic acid receptor 2. Genes, record 338442. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/338442

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Gene

Symbol
HCAR2
HGNC
Name
hydroxycarboxylic acid receptor 2
HGNC
NCBI Gene ID
338442
NCBI Gene
HGNC ID
HGNC:24827
HGNC
Ensembl
ENSG00000182782
NCBI Gene
Aliases
GPR109A, HCA2, HM74A, HM74a, HM74b, NIACR1, PUMAG, Puma-g
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8TDS4Hydroxycarboxylic acid receptor 236340Ensembl, GeneID, HGNC

Source UniProt

Patents46

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025529142 A2025-09-041918Q8TDS4Espacenet
US 12371689 B22025-07-291918Q8TDS4Espacenet
US 11446398 B22022-09-2039218Q8TDS4Espacenet
JP 2022524081 A2022-04-27142189Q8TDS4Espacenet
US 11078247 B22021-08-034887Q8TDS4Espacenet
US 10772934 B22020-09-151158Q8TDS4Espacenet
US 10292374 B22019-05-211555Q8TDS4Espacenet
US 9782454 B22017-10-101158Q8TDS4Espacenet
JP 2017121240 A2017-07-1350828Q8TDS4Espacenet
JP 2015518704 A2015-07-0650828Q8TDS4Espacenet

1 to 10 of 46

See all 46 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
SCH-900271CHEMBL2036958Hydroxycarboxylic acid receptor 2 agonistAGONIST

Source ChEMBL

Trials1

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first posted
NCT00941603SCH-900271PHASE22016-04-12

NIH grants965

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHCAR2 papersNewest fiscal year
P30ES010126UNC Center for Environmental Health and Susceptibility52025
P30DK048520Colorado Nutrition Obesity Research Center32025
P30DK063491Diabetes Research Center (DRC)32025
P30ES006694Southwest Environmental Health Sciences Center32025
R01HL016037Molecular Regulation of Cardiovascular 7 TM Receptors32025
UL1TR001863Yale Clinical and Translational Science Award32025
K01DK129410Microbiota-sourced purines in gut health and disease22025
P30AI027757University of Washington/Fred Hutch Center for AIDS Research22025
P30CA008748Cancer Center Support Grant22025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant22025

1 to 10 of 965Source NIH's project files

See all 965 nih grants

Papers1,788

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Short-Chain Fatty Acids in Sepsis: Mechanisms of Action and Therapeutic Advances.Biomedicines202642792734PubTator, text miningPubMed
β-hydroxybutyrate in depression: Neuropharmacological mechanisms and therapeutic potential.Prog Neuropsychopharmacol Biol Psychiatry202642753853PubTator, text miningPubMed
From metabolites to membrane vesicles: Unifying gut microbial signals in obesity, t2dm, and MASLD.World J Microbiol Biotechnol202642690471PubTator, text miningPubMed
NAD⁺ circuits in aging, tissue repair and fibrosis.Ageing Res Rev202642607935PubTator, text miningPubMed
Up-Regulation of Anthranilic Acid Formation and Pro-Cognitive Effect of Indoleamine 2,3-Dioxygenase Inhibition.Int J Tryptophan Res202642571168PubTator, text miningPubMed
Feeding the gut-immune axis: dietary, prebiotic, and probiotic strategies to target persistent inflammation in ART-treated HIV: a narrative review.Front Immunol202642539524PubTator, text miningPubMed
Gut‑bone metabolites: SCFAs, polyamines and microbial metabolomics in osteoporosis risk and therapy (Review).Int J Mol Med202642495772PubTator, text miningPubMed
Short-Chain Fatty Acid-Dependent Neuroimmune Regulation in Autism Spectrum Disorder Pathogenesis.Eur J Neurosci202642470181PubTator, text miningPubMed
Gut Microbiota, Immunity, and Metabolism in the Progression From Chronic Liver Disease to Hepatocellular Carcinoma.Adv Sci (Weinh)202642429613PubTator, text miningPubMed
State-Dependent Transcriptomic Collapse of the Brain's Lactate and Ketone Thermodynamic Sensors in Schizophrenia.bioRxiv202642427689PubTator, text miningPubMed

1 to 10 of 1,788

See all 1,788 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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