Gene · 338442
HCAR2: hydroxycarboxylic acid receptor 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. HCAR2: hydroxycarboxylic acid receptor 2. Genes, record 338442. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/338442
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q8TDS4 | Hydroxycarboxylic acid receptor 2 | 363 | 40 | Ensembl, GeneID, HGNC |
Source UniProt
Patents46
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2025529142 A | 2025-09-04 | 1918 | Q8TDS4 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1918 | Q8TDS4 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 39218 | Q8TDS4 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 142189 | Q8TDS4 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 4887 | Q8TDS4 | Espacenet |
| US 10772934 B2 | 2020-09-15 | 1158 | Q8TDS4 | Espacenet |
| US 10292374 B2 | 2019-05-21 | 1555 | Q8TDS4 | Espacenet |
| US 9782454 B2 | 2017-10-10 | 1158 | Q8TDS4 | Espacenet |
| JP 2017121240 A | 2017-07-13 | 50828 | Q8TDS4 | Espacenet |
| JP 2015518704 A | 2015-07-06 | 50828 | Q8TDS4 | Espacenet |
1 to 10 of 46
See all 46 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| SCH-900271 | CHEMBL2036958 | Hydroxycarboxylic acid receptor 2 agonist | AGONIST |
Source ChEMBL
Trials1
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted |
|---|---|---|---|
| NCT00941603 | SCH-900271 | PHASE2 | 2016-04-12 |
Source ClinicalTrials.gov
NIH grants965
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | HCAR2 papers | Newest fiscal year |
|---|---|---|---|
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 5 | 2025 |
| P30DK048520 | Colorado Nutrition Obesity Research Center | 3 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 3 | 2025 |
| P30ES006694 | Southwest Environmental Health Sciences Center | 3 | 2025 |
| R01HL016037 | Molecular Regulation of Cardiovascular 7 TM Receptors | 3 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 3 | 2025 |
| K01DK129410 | Microbiota-sourced purines in gut health and disease | 2 | 2025 |
| P30AI027757 | University of Washington/Fred Hutch Center for AIDS Research | 2 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 2 | 2025 |
| P30CA023074 | University of Arizona Cancer Center - Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 965Source NIH's project files
See all 965 nih grantsPapers1,788
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Short-Chain Fatty Acids in Sepsis: Mechanisms of Action and Therapeutic Advances. | Biomedicines | 2026 | 42792734 | PubTator, text mining | PubMed |
| β-hydroxybutyrate in depression: Neuropharmacological mechanisms and therapeutic potential. | Prog Neuropsychopharmacol Biol Psychiatry | 2026 | 42753853 | PubTator, text mining | PubMed |
| From metabolites to membrane vesicles: Unifying gut microbial signals in obesity, t2dm, and MASLD. | World J Microbiol Biotechnol | 2026 | 42690471 | PubTator, text mining | PubMed |
| NAD⁺ circuits in aging, tissue repair and fibrosis. | Ageing Res Rev | 2026 | 42607935 | PubTator, text mining | PubMed |
| Up-Regulation of Anthranilic Acid Formation and Pro-Cognitive Effect of Indoleamine 2,3-Dioxygenase Inhibition. | Int J Tryptophan Res | 2026 | 42571168 | PubTator, text mining | PubMed |
| Feeding the gut-immune axis: dietary, prebiotic, and probiotic strategies to target persistent inflammation in ART-treated HIV: a narrative review. | Front Immunol | 2026 | 42539524 | PubTator, text mining | PubMed |
| Gut‑bone metabolites: SCFAs, polyamines and microbial metabolomics in osteoporosis risk and therapy (Review). | Int J Mol Med | 2026 | 42495772 | PubTator, text mining | PubMed |
| Short-Chain Fatty Acid-Dependent Neuroimmune Regulation in Autism Spectrum Disorder Pathogenesis. | Eur J Neurosci | 2026 | 42470181 | PubTator, text mining | PubMed |
| Gut Microbiota, Immunity, and Metabolism in the Progression From Chronic Liver Disease to Hepatocellular Carcinoma. | Adv Sci (Weinh) | 2026 | 42429613 | PubTator, text mining | PubMed |
| State-Dependent Transcriptomic Collapse of the Brain's Lactate and Ketone Thermodynamic Sensors in Schizophrenia. | bioRxiv | 2026 | 42427689 | PubTator, text mining | PubMed |
1 to 10 of 1,788
See all 1,788 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/338442
GET https://conductscience.org/api/genes/v1/338442/patents?page=2