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IRF8: interferon regulatory factor 8

1 protein, 57 patents, 0 drugs, 0 trials, 3,751 NIH grants and 4,686 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIRF8HGNC
Nameinterferon regulatory factor 8HGNC
NCBI Gene ID3394NCBI Gene
HGNC IDHGNC:5358HGNC
EnsemblENSG00000140968NCBI Gene
AliasesH-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B, IRF-8NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q02556Interferon regulatory factor 84260Ensembl, GeneID, HGNCUniProt

Patents 57

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1450074Q02556Espacenet
EP 4641201 A22025-10-292250Q02556Espacenet
EP 4641202 A22025-10-294621Q02556Espacenet
JP 2025147176 A2025-10-0615176Q02556Espacenet
JP 2025517969 A2025-06-122250Q02556Espacenet
KR 1020250067969 A2025-05-1535Q02556Espacenet
JP 2025028160 A2025-02-2815176Q02556Espacenet
EP 4511478 A22025-02-266Q02556Espacenet
KR 1020250017231 A2025-02-044621Q02556Espacenet
KR 1020250010750 A2025-01-2115176Q02556Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3751

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIAHD001310Gene Regulation In The Immune System612,025NIH's project files
P30CA008748Cancer Center Support Grant332,025NIH's project files
P30CA016672Cancer Center Support Grant232,025NIH's project files
P30CA091842Cancer Center Support Grant172,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant152,025NIH's project files
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success152,025NIH's project files
T32CA085183Multidisciplinary Approaches to Tumor Immunology132,025NIH's project files
R01AI044938Inhibition of STAT3 and inflammatory cytokine production122,025NIH's project files
R01AR046713Cytokine regulation of RA synoviocyte phenotype122,025NIH's project files
ZIAHD008815Chromatin and epigenetic memory122,025NIH's project files

Papers 4686

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818937PubTator, text miningPubMed
42812170PubTator, text miningPubMed
42809590PubTator, text miningPubMed
42793339PubTator, text miningPubMed
42792602PubTator, text miningPubMed
42747963PubTator, text miningPubMed
42737545PubTator, text miningPubMed
42735565PubTator, text miningPubMed
42699253PubTator, text miningPubMed
42679804PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license