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Gene · 341

APOC1: apolipoprotein C1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. APOC1: apolipoprotein C1. Genes, record 341. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/341

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Gene

Symbol
APOC1
HGNC
Name
apolipoprotein C1
HGNC
NCBI Gene ID
341
NCBI Gene
HGNC ID
HGNC:607
HGNC
Ensembl
ENSG00000130208
NCBI Gene
Aliases
APOC1B, Apo-CI, ApoC-I, apo-CIB, apoC-IB
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P02654Apolipoprotein C-I838Ensembl, GeneID, HGNC

Source UniProt

Patents97

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1437666P02654Espacenet
EP 4650780 A22025-11-1917610P02654Espacenet
JP 2025147176 A2025-10-06952P02654Espacenet
JP 2025147176 A2025-10-06953P02654Espacenet
JP 2025529142 A2025-09-045504P02654Espacenet
US 12371689 B22025-07-295504P02654Espacenet
JP 2025517970 A2025-06-1217610P02654Espacenet
EP 4549945 A12025-05-076P02654Espacenet
JP 2025062601 A2025-04-146P02654Espacenet
JP 2025062604 A2025-04-145709P02654Espacenet

1 to 10 of 97

See all 97 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,576

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAPOC1 papersNewest fiscal year
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)342025
P30DK063491Diabetes Research Center (DRC)222025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal132025
U19AG024904Alzheimer's Disease Neuroimaging Initiative (ADNI4)122025
R01NS017950Precursors of Stroke Incidence and Prognosis112025
P30DK017047Diabetes Research Center82025
P30DK020572Michigan Diabetes Research Center (MDRC)72025
U01AG009740Health and Retirement Study: Yrs 35-4072025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions62025
P30AG034424Center for Population Health and Aging62025

1 to 10 of 2,576Source NIH's project files

See all 2,576 nih grants

Papers2,927

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Explainable Artificial Intelligence and Gene-Network Analysis Prioritise a TREM2/LGALS3/GPNMB Scar-Associated Macrophage Programme in Human Liver Cirrhosis.Int J Mol Sci202642794453PubTator, text miningPubMed
Maternal and offspring genome-wide association study of C-reactive protein reveals limited polygenic association with gestational diabetes mellitus.BMC Genomics202642786432PubTator, text miningPubMed
Hepatitis B virus proteome analysis identifies apolipoprotein C1 facilitating particle production and virus entry.Hepatology202642758966PubTator, text miningPubMed
APOC1-Associated VLDL-Pathway Dysregulation in Papillary Thyroid Carcinoma: A Reproducible Cross-Cohort Transcriptomic Signature Associated With the Diagnostic-to-Treatment Interval.Chem Biol Drug Des202642742374PubTator, text miningPubMed
Multi-omics mapping of PSC genetic risk to a high TWAS-active JAML+ lipid-associated macrophage program: bridging single-cell heterogeneity, spatial fibrotic niches, and machine learning selection.Front Cell Dev Biol202642707798PubTator, text miningPubMed
Integrated histopathology and single-cell transcriptomics reveal distinct pathological features and foamy macrophage characteristics in spinal tuberculosis and brucellar spondylitis.Front Immunol202642698543PubTator, text miningPubMed
Single-cell RNA sequencing reveals hypoxia-associated stress response signatures in the immune and stromal microenvironment of laryngeal squamous cell carcinoma.Front Immunol202642614551PubTator, text miningPubMed
Bioinformatics analysis combined with cell experiments reveals that APOC1 inhibits ferroptosis and promotes M2 macrophage polarization by activating the PI3K/AKT signaling pathway in oral squamous cell carcinoma cells.
Tissue Cell202642594501PubTator, text miningPubMed
Common genetic variants in dyslipidemia, inflammation, and angiogenesis pathways associated with diabetic nephropathy in Tunisians.Endocrine202642573890PubTator, text miningPubMed
APOC1 in tumor-associated macrophages enhances protumorigenic M2 polarization and promotes PAAD progression.Cell Signal202642567335PubTator, text miningPubMed

1 to 10 of 2,927

See all 2,927 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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