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Gene · 3416

IDE: insulin degrading enzyme

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IDE: insulin degrading enzyme. Genes, record 3416. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3416

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Gene

Symbol
IDE
HGNC
Name
insulin degrading enzyme
HGNC
NCBI Gene ID
3416
NCBI Gene
HGNC ID
HGNC:5381
HGNC
Ensembl
ENSG00000119912
NCBI Gene
Aliases
INSULYSIN
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P14735Insulin-degrading enzyme1,01962Ensembl, GeneID, HGNC

Source UniProt

Patents57

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449908P14735Espacenet
EP 4650780 A22025-11-192544P14735Espacenet
JP 2025147176 A2025-10-066700P14735Espacenet
JP 2025529142 A2025-09-046639P14735Espacenet
US 12371689 B22025-07-296639P14735Espacenet
JP 2025517970 A2025-06-122544P14735Espacenet
JP 2025028160 A2025-02-286700P14735Espacenet
KR 1020250010750 A2025-01-216700P14735Espacenet
JP 2024109657 A2024-08-146707P14735Espacenet
US 11760986 B22023-09-1937P14735Espacenet

1 to 10 of 57

See all 57 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,941

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIDE papersNewest fiscal year
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)132025
P01AG026572Perimenopause in Brain Aging and Alzheimer's Disease102025
P30DK063491Diabetes Research Center (DRC)92025
ZIAHG000024Genetic analysis of type II diabetes82025
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study72025
R01AA011431FASD Inhibition of ASPH-Notch Mediates Adolescent Cerebral White Matter Pathology-Potential Utility of Non-invasive Extracellular Vesicle Assays72025
R01DK062370Identifying Genes for Type 2 Diabetes: FUSION72025
P20GM103424Louisiana Biomedical Research Network62025
ZIAAI000430Molecular Biology Of Varicella Zoster Virus Infection62025
P30DK020572Michigan Diabetes Research Center (MDRC)52025

1 to 10 of 1,941Source NIH's project files

See all 1,941 nih grants

Papers2,652

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
[Corrigendum] Alteration of the Wnt/GSK3β/β‑catenin signalling pathway by rapamycin ameliorates pathology in an Alzheimer's disease model.Int J Mol Med202642825350PubTator, text miningPubMed
Diurnal Insulin Clearance and Circadian Metabolic Gene Signatures in MASLD: Integrative Multi-Dataset Physiological and Transcriptomic Analysis.Metabolites202642783754PubTator, text miningPubMed
Selective Inhibition of Insulin-Degrading Enzyme Eliminates Hemolysis Interference in Serum Insulin Measurements.Diagnostics (Basel)202642351586PubTator, text miningPubMed
scFv-based biologics in diabetes: from therapeutic potential to clinical prospects.Front Immunol202642327726PubTator, text miningPubMed
Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity.Elife202642253225PubTator, text miningPubMed
Genetic and clinical investigation of insulin-degrading enzyme in Parkinson's disease within the Chinese Han population.Front Neurosci202642232650PubTator, text miningPubMed
Membrane ATG8ylation in secretory autophagy.Autophagy202642178909PubTator, text miningPubMed
Insulin in brain: The physiological functions and therapeutic insights for neurodegenerative diseases.Life Sci202642142620PubTator, text miningPubMed
Dysregulated glucose metabolism in the visual cortex of human subjects with mild cognitive impairment and Alzheimer's disease.Front Aging Neurosci202642038694PubTator, text miningPubMed
Electromagnetic field induced activation of amyloid-β degrading enzyme, neprilysin, for accelerated Alzheimer's disease therapy.J Alzheimers Dis202642012352PubTator, text miningPubMed

1 to 10 of 2,652

See all 2,652 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3416

GET https://conductscience.org/api/genes/v1/3416/patents?page=2