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IDH1: isocitrate dehydrogenase (NADP(+)) 1

1 protein, 130 patents, 9 drugs, 91 trials, 7,823 NIH grants and 28,877 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIDH1HGNC
Nameisocitrate dehydrogenase (NADP(+)) 1HGNC
NCBI Gene ID3417NCBI Gene
HGNC IDHGNC:5382HGNC
EnsemblENSG00000138413NCBI Gene
AliasesHEL-216, HEL-S-26, IDCD, IDH, IDP, IDPC, PICDNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O75874Isocitrate dehydrogenase [NADP] cytoplasmic41462Ensembl, GeneID, HGNCUniProt

Patents 130

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-191834O75874Espacenet
EP 4641201 A22025-10-291420O75874Espacenet
EP 4641202 A22025-10-294511O75874Espacenet
JP 2025517969 A2025-06-121420O75874Espacenet
JP 2025517970 A2025-06-121834O75874Espacenet
KR 1020250017231 A2025-02-044511O75874Espacenet
EP 4494652 A22025-01-2276443O75874Espacenet
WO 2024257013 A2024-12-191O75874Espacenet
US 12168005 B22024-12-171O75874Espacenet
JP 2024123008 A2024-09-106702O75874Espacenet

Drugs 9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BAY1436032CHEMBL4206033Isocitrate dehydrogenase [NADP] cytoplasmic inhibitorINHIBITORChEMBL
DS-1001BCHEMBL4650282Isocitrate dehydrogenase [NADP] cytoplasmic inhibitorINHIBITORChEMBL
IDH305CHEMBL4167360Isocitrate dehydrogenase [NADP] cytoplasmic inhibitorINHIBITORChEMBL
IVOSIDENIBCHEMBL3989958Isocitrate dehydrogenase [NADP] cytoplasmic inhibitorINHIBITORChEMBL
OLUTASIDENIBCHEMBL4297610Isocitrate dehydrogenase [NADP] cytoplasmic inhibitorINHIBITORChEMBL
SAFUSIDENIBCHEMBL4651002Isocitrate dehydrogenase [NADP] cytoplasmic inhibitorINHIBITORChEMBL
VORASIDENIBCHEMBL4279047IDH1/IDH2 inhibitorINHIBITORChEMBL
VORASIDENIBCHEMBL4279047Isocitrate dehydrogenase [NADP] cytoplasmic inhibitorINHIBITORChEMBL
VORASIDENIB CITRATECHEMBL4594378Isocitrate dehydrogenase [NADP] cytoplasmic inhibitorINHIBITORChEMBL

Trials 91

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07607418IVOSIDENIBPHASE2ClinicalTrials.gov
NCT07604064OLUTASIDENIBPHASE2ClinicalTrials.gov
NCT07548710IVOSIDENIBPHASE2ClinicalTrials.gov
NCT07547163VORASIDENIBClinicalTrials.gov
NCT07507760IVOSIDENIBPHASE2ClinicalTrials.gov
NCT07471841OLUTASIDENIBPHASE2ClinicalTrials.gov
NCT07469735VORASIDENIBClinicalTrials.gov
NCT07463768IVOSIDENIBPHASE2ClinicalTrials.gov
NCT07411586OLUTASIDENIBPHASE1ClinicalTrials.gov
NCT07392242IVOSIDENIBPHASE2ClinicalTrials.gov

NIH grants 7823

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant3712,025NIH's project files
P30CA016672Cancer Center Support Grant3122,025NIH's project files
P50CA097257Brain Tumor SPORE Grant1272,025NIH's project files
P50CA211015UCLA SPORE in Brain Cancer932,025NIH's project files
P30CA006973Regional Oncology Research Center922,025NIH's project files
P50CA165962Targeted Therapies for Glioma822,025NIH's project files
P30CA016058Cancer Center Support Grant562,025NIH's project files
P50CA221747SPORE for Translational Approaches to Brain Cancer532,025NIH's project files
T32CA151022Training Program in Translational Brain Tumor Research482,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant462,025NIH's project files

Papers 28877

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826412PubTator, text miningPubMed
42825191PubTator, text miningPubMed
42824001PubTator, text miningPubMed
42823681PubTator, text miningPubMed
42823507PubTator, text miningPubMed
42822500PubTator, text miningPubMed
42822302PubTator, text miningPubMed
42821163PubTator, text miningPubMed
42820777PubTator, text miningPubMed
42820763PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license