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IDH2: isocitrate dehydrogenase (NADP(+)) 2

1 protein, 86 patents, 5 drugs, 50 trials, 3,863 NIH grants and 11,010 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIDH2HGNC
Nameisocitrate dehydrogenase (NADP(+)) 2HGNC
NCBI Gene ID3418NCBI Gene
HGNC IDHGNC:5383HGNC
EnsemblENSG00000182054NCBI Gene
AliasesD2HGA2, ICD-M, IDH, IDH-2, IDHM, IDP, IDPM, mNADP-IDHNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P48735Isocitrate dehydrogenase [NADP], mitochondrial45211Ensembl, GeneID, HGNCUniProt

Patents 86

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21161P48735Espacenet
EP 4650780 A22025-11-195936P48735Espacenet
EP 4641201 A22025-10-295663P48735Espacenet
EP 4641202 A22025-10-295035P48735Espacenet
JP 2025517969 A2025-06-125663P48735Espacenet
JP 2025517970 A2025-06-125936P48735Espacenet
KR 1020250017231 A2025-02-045035P48735Espacenet
WO 2024257013 A2024-12-192P48735Espacenet
JP 2024123008 A2024-09-106708P48735Espacenet
JP 2023521663 A2023-05-25160P48735Espacenet

Drugs 5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ENASIDENIBCHEMBL3989908Isocitrate dehydrogenase [NADP], mitochondrial inhibitorINHIBITORChEMBL
ENASIDENIB MESYLATECHEMBL3989931Isocitrate dehydrogenase [NADP], mitochondrial inhibitorINHIBITORChEMBL
VORASIDENIBCHEMBL4279047IDH1/IDH2 inhibitorINHIBITORChEMBL
VORASIDENIBCHEMBL4279047Isocitrate dehydrogenase [NADP], mitochondrial inhibitorINHIBITORChEMBL
VORASIDENIB CITRATECHEMBL4594378Isocitrate dehydrogenase [NADP], mitochondrial inhibitorINHIBITORChEMBL

Trials 50

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07547163VORASIDENIBClinicalTrials.gov
NCT07469735VORASIDENIBClinicalTrials.gov
NCT07286292VORASIDENIBPHASE2ClinicalTrials.gov
NCT07215910VORASIDENIBPHASE3ClinicalTrials.gov
NCT06969352VORASIDENIBClinicalTrials.gov
NCT06809322VORASIDENIBPHASE3ClinicalTrials.gov
NCT06780930VORASIDENIBPHASE3ClinicalTrials.gov
NCT06756308ENASIDENIBPHASE2ClinicalTrials.gov
NCT06672146ENASIDENIBPHASE2ClinicalTrials.gov
NCT06577441ENASIDENIBPHASE2ClinicalTrials.gov

NIH grants 3863

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant2042,025NIH's project files
P30CA016672Cancer Center Support Grant2042,025NIH's project files
P50CA097257Brain Tumor SPORE Grant442,025NIH's project files
P30CA006973Regional Oncology Research Center422,025NIH's project files
P30CA016058Cancer Center Support Grant372,025NIH's project files
P50CA165962Targeted Therapies for Glioma262,025NIH's project files
P50CA211015UCLA SPORE in Brain Cancer262,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant252,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award252,025NIH's project files
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias212,025NIH's project files

Papers 11010

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42809718PubTator, text miningPubMed
42803887PubTator, text miningPubMed
42774155PubTator, text miningPubMed
42756557PubTator, text miningPubMed
42754238PubTator, text miningPubMed
42741738PubTator, text miningPubMed
42736686PubTator, text miningPubMed
42733996PubTator, text miningPubMed
42728663PubTator, text miningPubMed
42719056PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license