Gene · 3423
IDS: iduronate 2-sulfatase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. IDS: iduronate 2-sulfatase. Genes, record 3423. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3423
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P22304 | Iduronate 2-sulfatase | 550 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents275
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4775992 A2 | 2026-07-15 | 1 | P22304 | Espacenet |
| EP 4775992 A2 | 2026-07-15 | 27 | P22304 | Espacenet |
| US 12636363 B2 | 2026-05-26 | 1 | P22304 | Espacenet |
| JP 2026077678 A | 2026-05-13 | 91 | P22304 | Espacenet |
| JP 2026067851 A | 2026-04-21 | 283 | P22304 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 6474 | P22304 | Espacenet |
| JP 2025170352 A | 2025-11-18 | 2 | P22304 | Espacenet |
| JP 2025170352 A | 2025-11-18 | 4 | P22304 | Espacenet |
| JP 2025170352 A | 2025-11-18 | 6 | P22304 | Espacenet |
| JP 2025170352 A | 2025-11-18 | 9 | P22304 | Espacenet |
1 to 10 of 275
See all 275 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants548
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | IDS papers | Newest fiscal year |
|---|---|---|---|
| R01DK067859 | Development of Assays for Newborn Screening and for Post-Screening Evaluation of Disease Severity | 17 | 2025 |
| R01HD102545 | Non-invasive functional assessment and pathogenesis of Morquio A | 4 | 2025 |
| ZIATR000018 | Drug Repurposing Screening for Rare and Neglected Diseases | 3 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 2 | 2025 |
| P30DK020579 | Diabetes Research Center | 2 | 2025 |
| R01NS092823 | The role of a-synuclein accumulation in lysosomal hydrolase trafficking and function | 2 | 2025 |
| T32HL007936 | Training Program in Translational Cardiovascular Science | 2 | 2025 |
| UL1TR001878 | Institutional Clinical and Translational Science Award | 2 | 2025 |
| ZIACL080013 | Molecular and Virulence Traits of Bacteria & Fungi Causing Persistent Infections | 2 | 2025 |
| ZICHL006145 | NHLBI iPSC Core Facility | 2 | 2025 |
1 to 10 of 548Source NIH's project files
See all 548 nih grantsPapers1,392
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Development and validation of an ELISA-based assay for detecting anti-idursulfase beta IgE antibodies in human serum using a conjugated IgG-IgE positive control antibody. | J Immunol Methods | 2026 | 42767399 | PubTator, text mining | PubMed |
| Longitudinal Assessment of Cognitive Development in 23 Patients With Mucopolysaccharidosis (MPS) Type II: Results of up to 14 Years of Follow-Up. | J Inherit Metab Dis | 2026 | 42723346 | PubTator, text mining | PubMed |
Interim analysis of post-marketing surveillance study of intracerebroventricular idursulfase therapy for neuronopathic mucopolysaccharidosis type II: Safety and effectiveness in clinical practice in Japan. | Mol Genet Metab | 2026 | 42679455 | PubTator, text mining | PubMed |
| Quantum Statistical Behaviors of Carriers in Strong Inversion Layers Associated with Mobility and Threshold Voltage in FinFET Transistors. | Micromachines (Basel) | 2026 | 42513019 | PubTator, text mining | PubMed |
| Sustained clinical benefit of idursulfase beta in mucopolysaccharidosis II: two-year experience from a phase 3 extension study including patients switched from idursulfase. | Orphanet J Rare Dis | 2026 | 42421116 | PubTator, text mining | PubMed |
| Integrative multi-omics analysis identifies a mitochondrial dysfunction-associated diagnostic signature, molecular subtypes, and drug repurposing candidates for keloid disease. | Burns | 2026 | 42413388 | PubTator, text mining | PubMed |
| Tividenofusp Alfa: First Approval. | Mol Diagn Ther | 2026 | 42313339 | PubTator, text mining | PubMed |
| Analytical Validation of MyProstateScore 2.0-Active Surveillance: A Urinary-Based Clinical RT-PCR Prostate Cancer Assay. | Diagnostics (Basel) | 2026 | 42196852 | PubTator, text mining | PubMed |
| Merging evans syndrome with mucopolysaccharidosis type II: a case report. | Front Pediatr | 2026 | 42158367 | PubTator, text mining | PubMed |
| Harmonizing Perspectives on MPS II Care in Türkiye: A Delphi Study Towards Treatment Management Consensus. | Healthcare (Basel) | 2026 | 42121657 | PubTator, text mining | PubMed |
1 to 10 of 1,392
See all 1,392 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3423
GET https://conductscience.org/api/genes/v1/3423/patents?page=2