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Gene · 3425

IDUA: alpha-L-iduronidase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IDUA: alpha-L-iduronidase. Genes, record 3425. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3425

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Gene

Symbol
IDUA
HGNC
Name
alpha-L-iduronidase
HGNC
NCBI Gene ID
3425
NCBI Gene
HGNC ID
HGNC:5391
HGNC
Ensembl
ENSG00000127415
NCBI Gene
Aliases
IDA, MPS1, MPSI
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P35475Alpha-L-iduronidase65311Ensembl, GeneID, HGNC

Source UniProt

Patents132

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026097826 A2026-06-161P35475Espacenet
JP 2026067851 A2026-04-21284P35475Espacenet
EP 4704920 A12026-03-11141P35475Espacenet
EP 4650780 A22025-11-191231P35475Espacenet
JP 2025169942 A2025-11-141080P35475Espacenet
EP 4640849 A22025-10-29137P35475Espacenet
EP 4641201 A22025-10-29877P35475Espacenet
EP 4641203 A22025-10-2935P35475Espacenet
JP 2025147176 A2025-10-066718P35475Espacenet
JP 2025529142 A2025-09-046642P35475Espacenet

1 to 10 of 132

See all 132 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,109

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIDUA papersNewest fiscal year
R01DK067859Development of Assays for Newborn Screening and for Post-Screening Evaluation of Disease Severity202025
T32GM008243UCLA Medical Genetics Training Program112025
P30AG066444Alzheimer's Disease Research Center52025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions42025
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies42025
P30CA015704Cancer Center Support Grant42025
R01HD102545Non-invasive functional assessment and pathogenesis of Morquio A42025
UL1TR001881UCLA Clinical and Translational Science Institute42025
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study32025
P30AG062422New Approaches to Dementia Heterogeneity32025

1 to 10 of 1,109Source NIH's project files

See all 1,109 nih grants

Papers1,870

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Unmasking Mucopolysaccharidosis Type I in a Patient With Wolf-Hirschhorn Syndrome: Diagnostic Overshadowing.JIMD Rep202642707122PubTator, text miningPubMed
Early detection in action: developing and refining newborn screening for Pompe disease in North Carolina.Mol Genet Metab202642691781PubTator, text miningPubMed
Multiplex MSMS measurement of lysosomal enzymes enables incidental diagnosis of acid sphingomyelinase deficiency in patients evaluated for Gaucher disease.Mol Genet Metab202642641356PubTator, text miningPubMed
First bone marrow transplantation for mucopolysaccharidosis type I in Vietnam: a case report.Ther Adv Rare Dis202642553443PubTator, text miningPubMed
Proteome-Wide Mendelian Randomization Identifies Causal Proteins for Multiple Sclerosis Susceptibility and Severity.Genes (Basel)202642510850PubTator, text miningPubMed
Identification of genetic variants associated with idiopathic inflammatory myopathies via cross-trait analysis with B cell lymphomas.HGG Adv202642499187PubTator, text miningPubMed
Oral nanoparticle-encapsulated enzyme replacement therapy for mucopolysaccharidosis type I (MPS-I): a proof of concept study.Drug Deliv Transl Res202642323476PubTator, text miningPubMed
Searching for New Genes That Cause Usher Syndrome.Am J Ophthalmol202642309414PubTator, text miningPubMed
Mucopolysaccharidosis type I with retinal degeneration and absence of corneal involvement in the eighth decade of life.Ophthalmic Genet202642246377PubTator, text miningPubMed
Variant classification for mucopolysaccharidosis type I; ACMG/AMP specification for IDUA from the ClinGen lysosomal diseases variant curation expert panel.Mol Genet Metab202642190545PubTator, text miningPubMed

1 to 10 of 1,870

See all 1,870 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3425

GET https://conductscience.org/api/genes/v1/3425/patents?page=2