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Gene · 3426

CFI: complement factor I

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CFI: complement factor I. Genes, record 3426. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3426

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Gene

Symbol
CFI
HGNC
Name
complement factor I
HGNC
NCBI Gene ID
3426
NCBI Gene
HGNC ID
HGNC:5394
HGNC
Ensembl
ENSG00000205403
NCBI Gene
Aliases
AHUS3, ARMD13, C3BINA, C3b-INA, C3bINA, FI, IF, KAF
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P05156Complement factor I5832Ensembl, GeneID, HGNC

Source UniProt

Patents94

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026120564 A2026-07-221P05156Espacenet
JP 2026041876 A2026-03-101P05156Espacenet
US 12544423 B22026-02-1025P05156Espacenet
JP 2026501750 A2026-01-1635P05156Espacenet
JP 2026004568 A2026-01-1442135P05156Espacenet
WO 2025262255 A12025-12-2639P05156Espacenet
WO 2025253101 A12025-12-1115P05156Espacenet
JP 2025539119 A2025-12-0314P05156Espacenet
KR 1020250163297 A2025-11-2035P05156Espacenet
EP 4650780 A22025-11-1911165P05156Espacenet

1 to 10 of 94

See all 94 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,574

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCFI papersNewest fiscal year
R01DK110023C3 Glomerulopathy -- A Collaborative Study122025
ZIAEY000489Age-Related Eye Disease Follow-up Study (AREDS) Follow-up Study82025
ZIAEY000546Mechanisms, modeling and therapies of retinal and macular neurodegeneration82025
P30AI064518Center for AIDS Research72025
P30EY014800University of Utah Core Vision Research Grant72025
P30CA008748Cancer Center Support Grant62025
P30EY005722Center Core Grant for Vision Research62025
UM1AI068618HIV Vaccine Trials Network Laboratory Center62025
K12EY016335Harvard-Vision Clinical Scientist Development Program52025
P30AI060354Harvard University Center for AIDS Research52025

1 to 10 of 1,574Source NIH's project files

See all 1,574 nih grants

Papers3,374

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A Network Analysis of Cognitive Flexibility, Emotion Regulation, and Symptom Severity in Patients with Major Depression.Psychiatr Q202642804067PubTator, text miningPubMed
Development and validation of a machine learning-based claims frailty index for predicting mortality, disability, and healthcare utilization in middle-aged and older adults.Exp Gerontol202642785600PubTator, text miningPubMed
Kidney transplant outcomes in patients with complement dysregulation.World J Transplant202642751233PubTator, text miningPubMed
Complement expression profiles in human glomerular mesangial cells, endothelial cells, podocytes and proximal tubular epithelial cells.Front Immunol202642746023PubTator, text miningPubMed
Genetic insights into lung squamous cell carcinoma: how TP53 and CSMD3 co-mutations shape prognosis and immune response.Transl Cancer Res202642724489PubTator, text miningPubMed
Artificial intelligence for precision therapeutics in age-related macular degeneration: current advances, challenges, and future directions.Front Artif Intell202642676384PubTator, text miningPubMed
Systemic and local dysregulation of the complement system in glioma: a comprehensive systematic review.Clin Transl Oncol202642627589PubTator, text miningPubMed
Biomarker-Informed Interpretation of Dyadic Cognitive Function Index Scores in Cognitively Unimpaired Older Adults.medRxiv202642619894PubTator, text miningPubMed
Genetic susceptibility to thrombotic microangiopathy in a 10-month-old patient with SMA type 1: a caveat for gene therapy eligibility.Neuromuscul Disord202642612481PubTator, text miningPubMed
Prospective associations of tea consumption with skeletal muscle mass and strength: Insights from the gut microbiome and proteomics.Pharmacol Res202642600761PubTator, text miningPubMed

1 to 10 of 3,374

See all 3,374 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3426

GET https://conductscience.org/api/genes/v1/3426/patents?page=2