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Gene · 3428

IFI16: interferon gamma inducible protein 16

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IFI16: interferon gamma inducible protein 16. Genes, record 3428. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3428

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Gene

Symbol
IFI16
HGNC
Name
interferon gamma inducible protein 16
HGNC
NCBI Gene ID
3428
NCBI Gene
HGNC ID
HGNC:5395
HGNC
Ensembl
ENSG00000163565
NCBI Gene
Aliases
IFNGIP1, PYHIN2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16666Gamma-interferon-inducible protein 167858Ensembl, GeneID, HGNC

Source UniProt

Patents30

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1450087Q16666Espacenet
EP 4641201 A22025-10-293246Q16666Espacenet
JP 2025147176 A2025-10-0615161Q16666Espacenet
JP 2025517969 A2025-06-123246Q16666Espacenet
JP 2025028160 A2025-02-2815161Q16666Espacenet
EP 4502181 A12025-02-0513Q16666Espacenet
KR 1020250010750 A2025-01-2115161Q16666Espacenet
JP 2024109657 A2024-08-1415000Q16666Espacenet
JP 2024522216 A2024-06-11112Q16666Espacenet
KR 1020240022540 A2024-02-20112Q16666Espacenet

1 to 10 of 30

See all 30 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,060

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIFI16 papersNewest fiscal year
P01CA019014Viral Oncogenesis, Latency, and Replication122025
P30AG017265USC/UCLA Center on Biodemography and Population Health92025
P30AI027763UCSF-Bay Area Center for AIDS Research92025
P30CA016672Cancer Center Support Grant82025
P30DK034854Integrated Epithelial and Muscosal Biology82025
P30CA008748Cancer Center Support Grant72025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center72025
R01AI124346Innate immune signaling and stress response72025
R37AI101935Inflammatory Caspases in Innate Immunity and Inflammation72025
T32AI095213Innate Immunity Training Program72025

1 to 10 of 2,060Source NIH's project files

See all 2,060 nih grants

Papers2,876

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Age as a biological stratifier for immune checkpoint inhibitor response in ovarian cancer.Res Sq202642779970PubTator, text miningPubMed
Multi-omics analysis identifies macrophage immunometabolic signatures in ulcerative colitis.Front Cell Infect Microbiol202642755516PubTator, text miningPubMed
Integrated multi-omics profiling identifies aging-related molecular signatures and convergent interferon signaling in systemic lupus erythematosus.Front Immunol202642688381PubTator, text miningPubMed
Cell death network regulation in HSV infection: immune evasion versus host defense.Apoptosis202642671474PubTator, text miningPubMed
[Exploring the impact of macrophage depletion on influenza viral pneumonia and its mechanism of action through the cGAS-STING pathway].Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi202642634902PubTator, text miningPubMed
Doxorubicin-induced damage to AC16 cardiomyocytes and attenuation by human pericardial fluid Sca-1+/Nanog+ cells conditioned medium: a pilot study.Biochim Biophys Acta Gen Subj202642612758PubTator, text miningPubMed
RADX protects against intestinal inflammation by restraining IFI16-mediated innate immunity.EMBO Mol Med202642498843PubTator, text miningPubMed
Transcriptomics, lifestyle, and autoimmune thyroiditis: an integrated association study.Front Immunol202642421942PubTator, text miningPubMed
Endosymbiotic theory of aging revisited: Age-related leakage of mitochondrial dsDNA/RNA stimulates cytosolic nucleic acid sensors which remodel the immune network and promote the aging process.Biogerontology202642412246PubTator, text miningPubMed
Discovery of Potential New Drug Targets for Osteoporosis of Various Subtypes With or Without Pathological Fracture Complications: A Drug Target Mendelian Randomization Study.Geriatr Gerontol Int202642366925PubTator, text miningPubMed

1 to 10 of 2,876

See all 2,876 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3428

GET https://conductscience.org/api/genes/v1/3428/patents?page=2