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Gene · 3437

IFIT3: interferon induced protein with tetratricopeptide repeats 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IFIT3: interferon induced protein with tetratricopeptide repeats 3. Genes, record 3437. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3437

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Gene

Symbol
IFIT3
HGNC
Name
interferon induced protein with tetratricopeptide repeats 3
HGNC
NCBI Gene ID
3437
NCBI Gene
HGNC ID
HGNC:5411
HGNC
Ensembl
ENSG00000119917
NCBI Gene
Aliases
CIG-49, GARG-49, IFI60, IFIT4, IRG2, ISG60, P60, RIG-G, cig41
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O14879Interferon-induced protein with tetratricopeptide repeats 34901Ensembl, GeneID, HGNC

Source UniProt

Patents94

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2025252547 A12025-12-1152O14879Espacenet
EP 4660322 A12025-12-1052O14879Espacenet
EP 4650780 A22025-11-199013O14879Espacenet
EP 4650780 A22025-11-199015O14879Espacenet
EP 4641202 A22025-10-295528O14879Espacenet
EP 4641202 A22025-10-295529O14879Espacenet
JP 2025517970 A2025-06-129013O14879Espacenet
JP 2025517970 A2025-06-129015O14879Espacenet
KR 1020250017231 A2025-02-045528O14879Espacenet
KR 1020250017231 A2025-02-045529O14879Espacenet

1 to 10 of 94

See all 94 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,742

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIFIT3 papersNewest fiscal year
P30CA008748Cancer Center Support Grant142025
P51OD011132Emory National Primate Research Center112025
P30CA047904Cancer Center Support Grant92025
P30CA016672Cancer Center Support Grant82025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center82025
P51OD010425Washington National Primate Research Center82025
UL1TR001863Yale Clinical and Translational Science Award82025
P30CA091842Cancer Center Support Grant72025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant72025
P30CA046934University of Colorado Cancer Center Support Grant62025

1 to 10 of 2,742Source NIH's project files

See all 2,742 nih grants

Papers3,172

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
SIRT1-mediated deacetylation of TRIM21 promotes IRF5 degradation and restrains type I interferon signatures in Sjögren's disease.Transl Res202642778089PubTator, text miningPubMed
Transcriptomic signatures of mind-body transformations therapy in breast cancer: Downregulation of the interferon signaling pathway.Breast202642748847PubTator, text miningPubMed
Identification of STAT1 as a biomarker for lymph node metastasis in esophageal squamous cell carcinoma.J Mol Histol202642700277PubTator, text miningPubMed
Role of IFIT1 and IFIT3 in systemic lupus erythematosus: modeling a diagnosis and exploring immune regulation.Clin Exp Med202642678612PubTator, text miningPubMed
Interferon-stimulated gene signature predicts clinical response to low-dose IL-2 in immune-mediated inflammatory diseases.Ann Rheum Dis202642618420PubTator, text miningPubMed
Systems-level insights into age-dependent innate immune responses in influenza B infection.Microbiol Spectr202642615604PubTator, text miningPubMed
IFIT3 silencing improves the sensitivity of gliomas to temozolomide by inactivating the PI3K/AKT signaling pathway.Behav Brain Res202642603632PubTator, text miningPubMed
Interferon-Associated Antiviral Programs Define LAG-3+ Exhaustion-Like CD8+ T-Cell Remodeling in Influenza a Virus Infection: An Integrative Single-Cell and Multi-Cohort Analysis.Immunol Invest202642533594PubTator, text miningPubMed
MX2 and IRF7 are Associated With Disease Activity and Renal Involvement in Systemic Lupus Erythematosus: An Exploratory Study.J Immunol Res202642504115PubTator, text miningPubMed
Multiparametric flow cytometry immune profiling of pulmonary and extra-pulmonary tuberculosis reveals distinct blood-based biomarker signatures.Tuberculosis (Edinb)202642501466PubTator, text miningPubMed

1 to 10 of 3,172

See all 3,172 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3437

GET https://conductscience.org/api/genes/v1/3437/patents?page=2