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APOC3: apolipoprotein C3

1 protein, 152 patents, 3 drugs, 19 trials, 3,067 NIH grants and 6,745 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolAPOC3HGNC
Nameapolipoprotein C3HGNC
NCBI Gene ID345NCBI Gene
HGNC IDHGNC:610HGNC
EnsemblENSG00000110245NCBI Gene
AliasesAPOCIII, Apo-C3, Apo-CIII, ApoC-3, ApoC-IIINCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P02656Apolipoprotein C-III991Ensembl, GeneID, HGNCUniProt

Patents 152

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1437669P02656Espacenet
WO 2025240940 A12025-11-20342P02656Espacenet
EP 4650780 A22025-11-19689P02656Espacenet
EP 4640849 A22025-10-2984P02656Espacenet
EP 4641201 A22025-10-29483P02656Espacenet
JP 2025147176 A2025-10-06966P02656Espacenet
JP 2025529142 A2025-09-045506P02656Espacenet
US 12371689 B22025-07-295506P02656Espacenet
JP 2025519096 A2025-06-2484P02656Espacenet
JP 2025517969 A2025-06-12483P02656Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
OLEZARSENCHEMBL4650438Apolipoprotein C-III mRNA antisense inhibitorANTISENSE INHIBITORChEMBL
VOLANESORSENCHEMBL3544994Apolipoprotein C-III mRNA 3'UTR antisense inhibitorANTISENSE INHIBITORChEMBL
VOLANESORSEN SODIUMCHEMBL3544989Apolipoprotein C-III mRNA 3'UTR antisense inhibitorANTISENSE INHIBITORChEMBL

Trials 19

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06360237OLEZARSENClinicalTrials.gov
NCT05681351OLEZARSENPHASE3ClinicalTrials.gov
NCT05610280OLEZARSENPHASE3ClinicalTrials.gov
NCT05552326OLEZARSENPHASE3ClinicalTrials.gov
NCT05355402OLEZARSENPHASE2ClinicalTrials.gov
NCT05185843OLEZARSENPHASE3ClinicalTrials.gov
NCT05130450OLEZARSENPHASE3ClinicalTrials.gov
NCT05079919OLEZARSENPHASE3ClinicalTrials.gov
NCT04568434OLEZARSENPHASE32025-03-06ClinicalTrials.gov
NCT03544060VOLANESORSENClinicalTrials.gov

NIH grants 3067

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK017047Diabetes Research Center352,025NIH's project files
P01HL151328Triglycerides, Diabetes and Cardiovascular Disease202,025NIH's project files
R35HL150754Identifying new strategies for prevention of cardiovascular complications of diabetes162,025NIH's project files
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)152,025NIH's project files
P30DK035816Nutrition Obesity Research Center112,025NIH's project files
P30DK063491Diabetes Research Center (DRC)102,025NIH's project files
R01HL109946Using genetics to discover mechanisms of abdominal aortic aneurysm92,025NIH's project files
P30DK020541NYR-Diabetes Research Center (NYR-DRC)82,025NIH's project files
P30DK045735Yale Diabetes Research Center82,025NIH's project files
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal82,025NIH's project files

Papers 6745

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42820004PubTator, text miningPubMed
42815576PubTator, text miningPubMed
42814299PubTator, text miningPubMed
42808066PubTator, text miningPubMed
42794744PubTator, text miningPubMed
42772683PubTator, text miningPubMed
42771980PubTator, text miningPubMed
42767870PubTator, text miningPubMed
42759771PubTator, text miningPubMed
42756632PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license