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Gene · 3455

IFNAR2: interferon alpha and beta receptor subunit 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IFNAR2: interferon alpha and beta receptor subunit 2. Genes, record 3455. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3455

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Gene

Symbol
IFNAR2
HGNC
Name
interferon alpha and beta receptor subunit 2
HGNC
NCBI Gene ID
3455
NCBI Gene
HGNC ID
HGNC:5433
HGNC
Ensembl
ENSG00000159110
NCBI Gene
Aliases
IFN-R, IFN-R-2, IFN-alpha-REC, IFNABR, IFNARB, IMD45
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P48551Interferon alpha/beta receptor 25159Ensembl, GeneID, HGNC

Source UniProt

Patents83

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026117686 A12026-06-0425P48551Espacenet
JP 2026004568 A2026-01-1450035P48551Espacenet
JP 2026004568 A2026-01-1450036P48551Espacenet
WO 2025247913 A12025-12-042P48551Espacenet
WO 2025247917 A12025-12-042P48551Espacenet
WO 2025247918 A12025-12-042P48551Espacenet
WO 2025247924 A12025-12-042P48551Espacenet
EP 4650780 A22025-11-196859P48551Espacenet
EP 4633648 A12025-10-2248P48551Espacenet
JP 2025147176 A2025-10-0617018P48551Espacenet

1 to 10 of 83

See all 83 patents

Drugs11

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALBINTERFERON ALFA-2BCHEMBL2107842Interferon alpha/beta receptor agonistAGONISTChEMBL
INTERFERON ALFA-2ACHEMBL2108508Interferon alpha/beta receptor agonistAGONISTChEMBL
INTERFERON ALFA-2BCHEMBL1201558Interferon alpha/beta receptor agonistAGONISTChEMBL
INTERFERON ALFA-N3CHEMBL2109047Interferon alpha/beta receptor agonistAGONISTChEMBL
INTERFERON ALFACON-1CHEMBL1201557Interferon alpha/beta receptor agonistAGONISTChEMBL
INTERFERON BETA-1ACHEMBL1201562Interferon alpha/beta receptor agonistAGONISTChEMBL
INTERFERON BETA-1BCHEMBL1201563Interferon alpha/beta receptor agonistAGONISTChEMBL
PEGINTERFERON ALFA-2ACHEMBL1201560Interferon alpha/beta receptor agonistAGONISTChEMBL
PEGINTERFERON ALFA-2BCHEMBL1201561Interferon alpha/beta receptor agonistAGONISTChEMBL
PEGINTERFERON BETA-1ACHEMBL2108677Interferon alpha/beta receptor agonistAGONISTChEMBL

1 to 10 of 11

See all 11 drugs

Trials1,349

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07553767INTERFERON ALFA-2BEARLY_PHASE1ClinicalTrials.gov
NCT07537387PEGINTERFERON ALFA-2AClinicalTrials.gov
NCT07521046ROPEGINTERFERON ALFA-2BPHASE1ClinicalTrials.gov
NCT07468916ROPEGINTERFERON ALFA-2BPHASE2ClinicalTrials.gov
NCT07445893INTERFERON ALFA-2BClinicalTrials.gov
NCT07445893PEGINTERFERON ALFA-2BClinicalTrials.gov
NCT07307586INTERFERON ALFA-2APHASE3ClinicalTrials.gov
NCT07288112PEGINTERFERON ALFA-2APHASE1/PHASE2ClinicalTrials.gov
NCT07282132ROPEGINTERFERON ALFA-2BClinicalTrials.gov
NCT07269470ROPEGINTERFERON ALFA-2BPHASE2ClinicalTrials.gov

1 to 10 of 1,349

See all 1,349 trials

NIH grants2,761

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIFNAR2 papersNewest fiscal year
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success452025
R01AI163029Inborn errors of immunity in patients with life-threatening COVID-19212025
P30CA008748Cancer Center Support Grant152025
UL1TR001863Yale Clinical and Translational Science Award132025
ZIAAI001265Host factors contributing to susceptibility to COVID-19 disease112025
R01AI127564Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis102025
P30CA046934University of Colorado Cancer Center Support Grant92025
ZIAAI001270Characterization of host immune responses to SARS-CoV-292025
R01AI051321Structure-based engineering of immune cytokine signaling82025
P30CA016042Cancer Center Support Grant72025

1 to 10 of 2,761Source NIH's project files

See all 2,761 nih grants

Papers3,850

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Host Genetic Susceptibility and Antiviral Immunity Shape the Pathogenesis and Outcomes of Herpes Simplex Encephalitis.Biology (Basel)202642792593PubTator, text miningPubMed
Functional divergence of the Bhanja virus NSs protein modulates interferon antagonism and viral fitness across divergent lineages.PLoS Pathog202642784634PubTator, text miningPubMed
Functional diversity of natural human IFNB1 variants in innate immunity.Sci Adv202642758835PubTator, text miningPubMed
TLR7/9 and type I interferon signaling reprogram neutrophil NET responses and impair antibacterial defense in systemic lupus erythematosus.Cell Press Blue202642746563PubTator, text miningPubMed
Integrated Inflammatory, Thrombo-Inflammatory, Redox and Soluble IFNAR2 Profiling During Hospitalization for COVID-19: An Exploratory Observational Cohort Study.J Clin Med202642739730PubTator, text miningPubMed
Transcriptomic profiling reveals immune signatures associated with potential COVID-19 susceptibility and a predictive framework in a Chinese cohort.Front Immunol202642698521PubTator, text miningPubMed
Regulators of interferon-responsive microglia uncovered by Genome-wide CRISPRi screening.NPJ Dement202642694111PubTator, text miningPubMed
IL-17A Restrains Antiviral Immunity to Promote Chikungunya Virus Infection and Pathogenesis in the Heart.bioRxiv202642620426PubTator, text miningPubMed
Developing and Characterizing a Murine Model of In Utero Transmission of Ebola Virus.bioRxiv202642620007PubTator, text miningPubMed
Disentangling Shared and Differential Genetic Architectures Between COVID-19 and Other Respiratory Disorders-A Genome-Wide Multi-Omics Framework.Int J Mol Sci202642511876PubTator, text miningPubMed

1 to 10 of 3,850

See all 3,850 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3455

GET https://conductscience.org/api/genes/v1/3455/patents?page=2