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Gene · 345611

IRGM: immunity related GTPase M

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IRGM: immunity related GTPase M. Genes, record 345611. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/345611

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Gene

Symbol
IRGM
HGNC
Name
immunity related GTPase M
HGNC
NCBI Gene ID
345611
NCBI Gene
HGNC ID
HGNC:29597
HGNC
Ensembl
ENSG00000237693
NCBI Gene
Aliases
IBD19, IFI1, IRGM1, LRG-47, LRG47
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
A1A4Y4Immunity-related GTPase family M protein1810Ensembl, GeneID, HGNC

Source UniProt

Patents14

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449646A1A4Y4Espacenet
EP 4641201 A22025-10-2917954A1A4Y4Espacenet
JP 2025517969 A2025-06-1217954A1A4Y4Espacenet
US 11446398 B22022-09-2039561A1A4Y4Espacenet
JP 2022524081 A2022-04-27142532A1A4Y4Espacenet
US 11078247 B22021-08-035584A1A4Y4Espacenet
JP 2019054813 A2019-04-11230081A1A4Y4Espacenet
JP 2017121241 A2017-07-13230081A1A4Y4Espacenet
JP 2015516143 A2015-06-08230081A1A4Y4Espacenet
EP 2450456 A22012-05-09124A1A4Y4Espacenet

1 to 10 of 14

See all 14 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,032

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIRGM papersNewest fiscal year
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital292025
U01DK062432Montreal-Boston Collaborative GRC162025
U01DK062422Mount Sinai NYC Genetics Research Center: Multi-omic integration across data-types, cell niches and populations132025
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)122025
U01DK062413Determining genomic and host-environment contributions to IBD phenotypes122025
U01DK062431IBD Gene Mapping by Clinical and Population Subset122025
U01DK062423Genomic and Immunologic Characterization of Inflammatory Bowel Disease and its Phenotypes112025
P30DK052574Host-environment interactions in the pathophysiology of digestive disease82025
R01DK088199Endoplasmic reticulum stress and intestinal inflammation82025
P20GM121176Autophagy, Inflammation and Metabolism (AIM) in Disease Center - Phase 2.72025

1 to 10 of 1,032Source NIH's project files

See all 1,032 nih grants

Papers1,378

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
From gut to pancreas: Shared genetic susceptibility and biological convergence in acute pancreatitis and Crohn's disease.PLoS One202642726709PubTator, text miningPubMed
Epigenetic profiling reveals M1 macrophages as the primary drivers of trained immunity in HSV-1 latently infected mice.PLoS Pathog202642715287PubTator, text miningPubMed
IRGM genetic variants associate with tuberculosis disease in a European population.Int J Infect Dis202642537778PubTator, text miningPubMed
m6A RNA methylation modulates IFN-γ-stimulated intestinal epithelial cell-intrinsic antiparasitic defense.PLoS Pathog202642475356PubTator, text miningPubMed
Biomarkers in the pathogenesis and diagnosis of Crohn's perianal fistulas: a systematic review.Tech Coloproctol202642329424PubTator, text miningPubMed
Pro-inflammatory microbiota mediates the effect of host risk genes in Crohn's disease.Front Microbiol202642317752PubTator, text miningPubMed
mSphere of Influence: Host-pathogen interactions-the fascinating world of molecular interplay.mSphere202642017674PubTator, text miningPubMed
Disrupting the TGF-β-regulated epithelial-mesenchymal transition, apoptotic and autophagic phenotypes of 3D glioblastoma spheroids via glycolytic inhibition.Explor Target Antitumor Ther202642003977PubTator, text miningPubMed
Irgm1 Restrains CD8+ T Cell Cytokine Production and Apoptosis via Cell-Extrinsic Regulation of Type I Interferon Signaling.Eur J Immunol202641906618PubTator, text miningPubMed
IRGM1-IRF7 Axis Controls Macrophage Chemotaxis to Orchestrate Skeletal Muscle Regeneration.Inflammation202641862677PubTator, text miningPubMed

1 to 10 of 1,378

See all 1,378 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/345611

GET https://conductscience.org/api/genes/v1/345611/patents