Gene · 345611
IRGM: immunity related GTPase M
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. IRGM: immunity related GTPase M. Genes, record 345611. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/345611
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| A1A4Y4 | Immunity-related GTPase family M protein | 181 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents14
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 49646 | A1A4Y4 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 17954 | A1A4Y4 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 17954 | A1A4Y4 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 39561 | A1A4Y4 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 142532 | A1A4Y4 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 5584 | A1A4Y4 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 230081 | A1A4Y4 | Espacenet |
| JP 2017121241 A | 2017-07-13 | 230081 | A1A4Y4 | Espacenet |
| JP 2015516143 A | 2015-06-08 | 230081 | A1A4Y4 | Espacenet |
| EP 2450456 A2 | 2012-05-09 | 124 | A1A4Y4 | Espacenet |
1 to 10 of 14
See all 14 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,032
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | IRGM papers | Newest fiscal year |
|---|---|---|---|
| P30DK043351 | Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital | 29 | 2025 |
| U01DK062432 | Montreal-Boston Collaborative GRC | 16 | 2025 |
| U01DK062422 | Mount Sinai NYC Genetics Research Center: Multi-omic integration across data-types, cell niches and populations | 13 | 2025 |
| P30DK040561 | Boston Area Nutrition Obesity Research Center (NORC) | 12 | 2025 |
| U01DK062413 | Determining genomic and host-environment contributions to IBD phenotypes | 12 | 2025 |
| U01DK062431 | IBD Gene Mapping by Clinical and Population Subset | 12 | 2025 |
| U01DK062423 | Genomic and Immunologic Characterization of Inflammatory Bowel Disease and its Phenotypes | 11 | 2025 |
| P30DK052574 | Host-environment interactions in the pathophysiology of digestive disease | 8 | 2025 |
| R01DK088199 | Endoplasmic reticulum stress and intestinal inflammation | 8 | 2025 |
| P20GM121176 | Autophagy, Inflammation and Metabolism (AIM) in Disease Center - Phase 2. | 7 | 2025 |
1 to 10 of 1,032Source NIH's project files
See all 1,032 nih grantsPapers1,378
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| From gut to pancreas: Shared genetic susceptibility and biological convergence in acute pancreatitis and Crohn's disease. | PLoS One | 2026 | 42726709 | PubTator, text mining | PubMed |
| Epigenetic profiling reveals M1 macrophages as the primary drivers of trained immunity in HSV-1 latently infected mice. | PLoS Pathog | 2026 | 42715287 | PubTator, text mining | PubMed |
| IRGM genetic variants associate with tuberculosis disease in a European population. | Int J Infect Dis | 2026 | 42537778 | PubTator, text mining | PubMed |
| m6A RNA methylation modulates IFN-γ-stimulated intestinal epithelial cell-intrinsic antiparasitic defense. | PLoS Pathog | 2026 | 42475356 | PubTator, text mining | PubMed |
| Biomarkers in the pathogenesis and diagnosis of Crohn's perianal fistulas: a systematic review. | Tech Coloproctol | 2026 | 42329424 | PubTator, text mining | PubMed |
| Pro-inflammatory microbiota mediates the effect of host risk genes in Crohn's disease. | Front Microbiol | 2026 | 42317752 | PubTator, text mining | PubMed |
| mSphere of Influence: Host-pathogen interactions-the fascinating world of molecular interplay. | mSphere | 2026 | 42017674 | PubTator, text mining | PubMed |
| Disrupting the TGF-β-regulated epithelial-mesenchymal transition, apoptotic and autophagic phenotypes of 3D glioblastoma spheroids via glycolytic inhibition. | Explor Target Antitumor Ther | 2026 | 42003977 | PubTator, text mining | PubMed |
| Irgm1 Restrains CD8+ T Cell Cytokine Production and Apoptosis via Cell-Extrinsic Regulation of Type I Interferon Signaling. | Eur J Immunol | 2026 | 41906618 | PubTator, text mining | PubMed |
| IRGM1-IRF7 Axis Controls Macrophage Chemotaxis to Orchestrate Skeletal Muscle Regeneration. | Inflammation | 2026 | 41862677 | PubTator, text mining | PubMed |
1 to 10 of 1,378
See all 1,378 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/345611
GET https://conductscience.org/api/genes/v1/345611/patents