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Gene · 3459

IFNGR1: interferon gamma receptor 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IFNGR1: interferon gamma receptor 1. Genes, record 3459. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3459

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Gene

Symbol
IFNGR1
HGNC
Name
interferon gamma receptor 1
HGNC
NCBI Gene ID
3459
NCBI Gene
HGNC ID
HGNC:5439
HGNC
Ensembl
ENSG00000027697
NCBI Gene
Aliases
CD119, IFNGR, IMD27A, IMD27B
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P15260Interferon gamma receptor 14895Ensembl, GeneID, HGNC

Source UniProt

Patents96

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12617829 B22026-05-0588P15260Espacenet
JP 2026004568 A2026-01-1450040P15260Espacenet
EP 4650780 A22025-11-198286P15260Espacenet
EP 4641201 A22025-10-298470P15260Espacenet
EP 4633648 A12025-10-2249P15260Espacenet
JP 2025156512 A2025-10-1488P15260Espacenet
JP 2025147176 A2025-10-066747P15260Espacenet
JP 2025147176 A2025-10-0616685P15260Espacenet
JP 2025133877 A2025-09-1188P15260Espacenet
JP 2025529142 A2025-09-042044P15260Espacenet

1 to 10 of 96

See all 96 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
INTERFERON GAMMA-1BCHEMBL1201564Interferon gamma receptor agonistAGONIST

Source ChEMBL

Trials86

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06529731INTERFERON GAMMA-1BPHASE2ClinicalTrials.gov
NCT06381661INTERFERON GAMMA-1BPHASE2ClinicalTrials.gov
NCT06222801INTERFERON GAMMA-1BClinicalTrials.gov
NCT06118619INTERFERON GAMMA-1BClinicalTrials.gov
NCT05843786INTERFERON GAMMA-1BPHASE3ClinicalTrials.gov
NCT05653193INTERFERON GAMMA-1BPHASE2ClinicalTrials.gov
NCT05386459INTERFERON GAMMA-1BClinicalTrials.gov
NCT05378646INTERFERON GAMMA-1BPHASE3ClinicalTrials.gov
NCT05359315INTERFERON GAMMA-1BClinicalTrials.gov
NCT05156541INTERFERON GAMMA-1BPHASE3ClinicalTrials.gov

1 to 10 of 86

See all 86 trials

NIH grants3,098

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIFNGR1 papersNewest fiscal year
ZIAAI000647Genes And Gene Products As Immunoadjuvants362025
P30CA008748Cancer Center Support Grant302025
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success262025
P30CA016672Cancer Center Support Grant162025
ZIAAI000646Transgenic Animal Models Of Human Immune Defects162025
ZIAAI001122Studies of Inherited Causes of Fungal Susceptability132025
R01AI127564Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis112025
ZIACL010304Mutation Analysis Of Selected Lymphoid Immune Disorders92025
R01AI095983Genome-Wide Dissection of Mendelian Susceptibility to Mycobacterial Disease82025
P30CA047904Cancer Center Support Grant72025

1 to 10 of 3,098Source NIH's project files

See all 3,098 nih grants

Papers3,929

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Cobalt-mediated suppression of IFN-γ-JAK-STAT1 signaling reprograms IDO1-driven immunosuppression for metalloimmunotherapy.Sci Adv202642758828PubTator, text miningPubMed
Spatial transcriptomics reveals immune remodeling in lymph nodes of gastric adenocarcinoma.Clin Exp Metastasis202642754734PubTator, text miningPubMed
Spatial and functional specialization of human splenic innate lymphoid cells.Nat Commun202642711319PubTator, text miningPubMed
Mycobacterial infections and recurrent osteomyelitis in a patient with an autosomal dominant mutation in IFN-gamma receptor 1 with overexpression of the receptor.Int J Infect Dis202642702282PubTator, text miningPubMed
Reduction of CXCR3+CCR6+ CD4+ T Cells and IL-17+ RORγt+ CD4+ T Cells During Secukinumab Treatment Identifies Patients With Axial Spondyloarthritis Responsive to Subsequent Biologic Therapy.ACR Open Rheumatol202642666100PubTator, text miningPubMed
Deciphering HPV-Associated Immune Evasion in Cervical Cancer Through Multi-Omics Profiling and Computational Screening.Anal Cell Pathol (Amst)202642635083PubTator, text miningPubMed
mi-RNA-mRNA Alterations in Sorted T-Cells of Acquired Aplastic Anemia: Validating the Observations of a Pilot Study.Int J Lab Hematol202642604788PubTator, text miningPubMed
Immune exhaustion in esophageal cancer: interferon pathway dysregulation and neoadjuvant therapy response.Front Cell Dev Biol202642597607PubTator, text miningPubMed
KRASG12D inhibition reprograms the tumor-induced immunosuppressive environment and enhances NK cell-mediated antitumor immunity.Sci Adv202642490421PubTator, text miningPubMed
Triple IFN pathway deficiency sensitizes mice to human respiratory virus infection independent of human viral receptor expression.Nat Commun202642463654PubTator, text miningPubMed

1 to 10 of 3,929

See all 3,929 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3459

GET https://conductscience.org/api/genes/v1/3459/patents?page=2