Gene · 3459
IFNGR1: interferon gamma receptor 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. IFNGR1: interferon gamma receptor 1. Genes, record 3459. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3459
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P15260 | Interferon gamma receptor 1 | 489 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents96
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12617829 B2 | 2026-05-05 | 88 | P15260 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 50040 | P15260 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8286 | P15260 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8470 | P15260 | Espacenet |
| EP 4633648 A1 | 2025-10-22 | 49 | P15260 | Espacenet |
| JP 2025156512 A | 2025-10-14 | 88 | P15260 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 6747 | P15260 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 16685 | P15260 | Espacenet |
| JP 2025133877 A | 2025-09-11 | 88 | P15260 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2044 | P15260 | Espacenet |
1 to 10 of 96
See all 96 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| INTERFERON GAMMA-1B | CHEMBL1201564 | Interferon gamma receptor agonist | AGONIST |
Source ChEMBL
Trials86
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT06529731 | INTERFERON GAMMA-1B | PHASE2 | ClinicalTrials.gov | |
| NCT06381661 | INTERFERON GAMMA-1B | PHASE2 | ClinicalTrials.gov | |
| NCT06222801 | INTERFERON GAMMA-1B | ClinicalTrials.gov | ||
| NCT06118619 | INTERFERON GAMMA-1B | ClinicalTrials.gov | ||
| NCT05843786 | INTERFERON GAMMA-1B | PHASE3 | ClinicalTrials.gov | |
| NCT05653193 | INTERFERON GAMMA-1B | PHASE2 | ClinicalTrials.gov | |
| NCT05386459 | INTERFERON GAMMA-1B | ClinicalTrials.gov | ||
| NCT05378646 | INTERFERON GAMMA-1B | PHASE3 | ClinicalTrials.gov | |
| NCT05359315 | INTERFERON GAMMA-1B | ClinicalTrials.gov | ||
| NCT05156541 | INTERFERON GAMMA-1B | PHASE3 | ClinicalTrials.gov |
1 to 10 of 86
See all 86 trialsNIH grants3,098
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | IFNGR1 papers | Newest fiscal year |
|---|---|---|---|
| ZIAAI000647 | Genes And Gene Products As Immunoadjuvants | 36 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 30 | 2025 |
| UL1TR001866 | Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success | 26 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 16 | 2025 |
| ZIAAI000646 | Transgenic Animal Models Of Human Immune Defects | 16 | 2025 |
| ZIAAI001122 | Studies of Inherited Causes of Fungal Susceptability | 13 | 2025 |
| R01AI127564 | Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis | 11 | 2025 |
| ZIACL010304 | Mutation Analysis Of Selected Lymphoid Immune Disorders | 9 | 2025 |
| R01AI095983 | Genome-Wide Dissection of Mendelian Susceptibility to Mycobacterial Disease | 8 | 2025 |
| P30CA047904 | Cancer Center Support Grant | 7 | 2025 |
1 to 10 of 3,098Source NIH's project files
See all 3,098 nih grantsPapers3,929
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Cobalt-mediated suppression of IFN-γ-JAK-STAT1 signaling reprograms IDO1-driven immunosuppression for metalloimmunotherapy. | Sci Adv | 2026 | 42758828 | PubTator, text mining | PubMed |
| Spatial transcriptomics reveals immune remodeling in lymph nodes of gastric adenocarcinoma. | Clin Exp Metastasis | 2026 | 42754734 | PubTator, text mining | PubMed |
| Spatial and functional specialization of human splenic innate lymphoid cells. | Nat Commun | 2026 | 42711319 | PubTator, text mining | PubMed |
| Mycobacterial infections and recurrent osteomyelitis in a patient with an autosomal dominant mutation in IFN-gamma receptor 1 with overexpression of the receptor. | Int J Infect Dis | 2026 | 42702282 | PubTator, text mining | PubMed |
| Reduction of CXCR3+CCR6+ CD4+ T Cells and IL-17+ RORγt+ CD4+ T Cells During Secukinumab Treatment Identifies Patients With Axial Spondyloarthritis Responsive to Subsequent Biologic Therapy. | ACR Open Rheumatol | 2026 | 42666100 | PubTator, text mining | PubMed |
| Deciphering HPV-Associated Immune Evasion in Cervical Cancer Through Multi-Omics Profiling and Computational Screening. | Anal Cell Pathol (Amst) | 2026 | 42635083 | PubTator, text mining | PubMed |
| mi-RNA-mRNA Alterations in Sorted T-Cells of Acquired Aplastic Anemia: Validating the Observations of a Pilot Study. | Int J Lab Hematol | 2026 | 42604788 | PubTator, text mining | PubMed |
| Immune exhaustion in esophageal cancer: interferon pathway dysregulation and neoadjuvant therapy response. | Front Cell Dev Biol | 2026 | 42597607 | PubTator, text mining | PubMed |
| KRASG12D inhibition reprograms the tumor-induced immunosuppressive environment and enhances NK cell-mediated antitumor immunity. | Sci Adv | 2026 | 42490421 | PubTator, text mining | PubMed |
| Triple IFN pathway deficiency sensitizes mice to human respiratory virus infection independent of human viral receptor expression. | Nat Commun | 2026 | 42463654 | PubTator, text mining | PubMed |
1 to 10 of 3,929
See all 3,929 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3459
GET https://conductscience.org/api/genes/v1/3459/patents?page=2