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Gene · 347733

TUBB2B: tubulin beta 2B class IIb

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TUBB2B: tubulin beta 2B class IIb. Genes, record 347733. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/347733

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Gene

Symbol
TUBB2B
HGNC
Name
tubulin beta 2B class IIb
HGNC
NCBI Gene ID
347733
NCBI Gene
HGNC ID
HGNC:30829
HGNC
Ensembl
ENSG00000137285
NCBI Gene
Aliases
CDCBM7, DKFZp566F223, MGC8685, PMGYSA, bA506K6.1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9BVA1Tubulin beta-2B chain4453Ensembl, GeneID, HGNC

Source UniProt

Patents30

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1468525Q9BVA1Espacenet
JP 2025032204 A2025-03-1137877Q9BVA1Espacenet
EP 4461818 A22024-11-1337877Q9BVA1Espacenet
US 11860162 B22024-01-021581Q9BVA1Espacenet
JP 2023058610 A2023-04-2537877Q9BVA1Espacenet
US 11446398 B22022-09-2093578Q9BVA1Espacenet
JP 2022092366 A2022-06-22650Q9BVA1Espacenet
JP 2022524081 A2022-04-27196549Q9BVA1Espacenet
US 11078247 B22021-08-0312152Q9BVA1Espacenet
JP 2021018154 A2021-02-15991Q9BVA1Espacenet

1 to 10 of 30

See all 30 patents

Drugs91

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABT-751CHEMBL20684Tubulin beta inhibitorINHIBITORChEMBL
AGS-16C3FCHEMBL4594455Tubulin disrupting agentDISRUPTING AGENTChEMBL
ANETUMAB RAVTANSINECHEMBL2109629Tubulin inhibitorINHIBITORChEMBL
ANG1005CHEMBL1089636Tubulin inhibitorINHIBITORChEMBL
ANVATABART OPADOTINCHEMBL4297892Tubulin inhibitorINHIBITORChEMBL
APRUTUMAB IXADOTINCHEMBL4650293Tubulin inhibitorINHIBITORChEMBL
ASG-5MECHEMBL2109574Tubulin inhibitorINHIBITORChEMBL
AVE-9633CHEMBL2109266Tubulin inhibitorINHIBITORChEMBL
AZINTUXIZUMAB VEDOTINCHEMBL4297859Tubulin inhibitorINHIBITORChEMBL
BELANTAMAB MAFODOTINCHEMBL4298209Tubulin inhibitorINHIBITORChEMBL

1 to 10 of 91

See all 91 drugs

Trials8,740

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07604766PACLITAXELPHASE3ClinicalTrials.gov
NCT07602907PACLITAXELPHASE2ClinicalTrials.gov
NCT07601737PACLITAXELPHASE2ClinicalTrials.gov
NCT07601178PACLITAXELPHASE2ClinicalTrials.gov
NCT07599163PACLITAXELClinicalTrials.gov
NCT07595770PACLITAXELPHASE2ClinicalTrials.gov
NCT07594548PACLITAXELPHASE1ClinicalTrials.gov
NCT07591467DOCETAXELPHASE3ClinicalTrials.gov
NCT07589972VINORELBINEClinicalTrials.gov
NCT07588698VINCRISTINE SULFATEPHASE2ClinicalTrials.gov

1 to 10 of 8,740

See all 8,740 trials

NIH grants596

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTUBB2B papersNewest fiscal year
R01NS058721ACC: Callosal Agenesis as a Window into Common Neurodevelopmental Disorders112025
T32EY007143Visual Science Training Program42025
T32ES018827Research Training in Environmental Toxicology32025
P30CA016042Cancer Center Support Grant22025
P30CA062203Cancer Center Support Grant22025
P30EY014104P30 Core Grant for Vision Research22025
P50HD105351Boston Children's Hospital/HMS Intellectual and Developmental Disabilities Research Center22025
R01HD086634Specialized Translational Control of Stem Cell Differentiation and Embryonic Development22025
R01NS032457Cell Identity Determination in Human Brain: Somatic Mutation and Cell Lineage22025
R35GM122522Genetic analysis of nematode cell differentiation22025

1 to 10 of 596Source NIH's project files

See all 596 nih grants

Papers814

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Developmental Profiles Associated with TUBA1A, TUBB2A, TUBB2B, and TUBB3 Tubulinopathy Conditions.Am J Intellect Dev Disabil202642593952PubTator, text miningPubMed
Genotypic and phenotypic heterogeneity in tubulinopathies: insights from a Turkish multicenter cohort.Neurol Sci202642472988PubTator, text miningPubMed
Expanding the clinical and molecular spectrum of TUBB2B through distinct variants identified across multiple families.HGG Adv202642470103PubTator, text miningPubMed
Identification of potential vinorelbine-associated prognostic genes in breast cancer through integrative bioinformatics and experimental validation.Front Oncol202642434754PubTator, text miningPubMed
Identification of tubulin gene variants in patients with dandy-walker malformation: expanding the spectrum of tubulinopathies.Mol Cytogenet202642310787PubTator, text miningPubMed
Genetic causes of the lissencephaly spectrum: insights from chromosomal microarray and clinical/whole-exome sequencing.Croat Med J202642286901PubTator, text miningPubMed
Identification and external validation of a prognostic signature based on bone morphogenetic protein-related mRNAs for kidney renal clear cell carcinoma.Discov Oncol202642250062PubTator, text miningPubMed
Investigating the Function of C‑Terminal Tails of Human Tubulin Isotypes in the Motility Regulation of Cytoplasmic Dynein.ACS Omega202642179625PubTator, text miningPubMed
Architects of the Developing Brain: Cytoskeleton-Organizing Molecules in Neurodevelopmental Disorders.Cells202641892327PubTator, text miningPubMed
Genetic landscape and phenotypic correlations of lissencephaly: prenatal and postnatal insights.Brain Commun202641853045PubTator, text miningPubMed

1 to 10 of 814

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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