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IGF1: insulin like growth factor 1

1 protein, 139 patents, 2 drugs, 9 trials, 22,988 NIH grants and 85,536 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIGF1HGNC
Nameinsulin like growth factor 1HGNC
NCBI Gene ID3479NCBI Gene
HGNC IDHGNC:5464HGNC
EnsemblENSG00000017427NCBI Gene
AliasesIGF, IGF-I, IGF1A, IGFI, MGFNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P05019Insulin-like growth factor 119532Ensembl, GeneID, HGNCUniProt

Patents 139

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026187925 A12026-09-1091P05019Espacenet
JP 2026514089 A2026-05-0158P05019Espacenet
EP 4716540 A12026-04-0154P05019Espacenet
JP 2026500184 A2026-01-064P05019Espacenet
WO 2025260074 A12025-12-1833P05019Espacenet
JP 2025538460 A2025-11-2817P05019Espacenet
WO 2025245381 A12025-11-27154P05019Espacenet
WO 2025227129 A22025-10-3044P05019Espacenet
WO 2025219552 A12025-10-237P05019Espacenet
KR 1020250152054 A2025-10-2217P05019Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DUSIGITUMABCHEMBL2109355Insulin-like growth factor I inhibitorINHIBITORChEMBL
XENTUZUMABCHEMBL4297850Insulin-like growth factor I inhibitorINHIBITORChEMBL

Trials 9

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05110495XENTUZUMABEARLY_PHASE12025-02-17ClinicalTrials.gov
NCT03659136XENTUZUMABPHASE22022-09-29ClinicalTrials.gov
NCT03099174XENTUZUMABPHASE12025-06-24ClinicalTrials.gov
NCT02204072XENTUZUMABPHASE12025-07-15ClinicalTrials.gov
NCT02191891XENTUZUMABPHASE12025-06-25ClinicalTrials.gov
NCT02145741XENTUZUMABPHASE12025-06-19ClinicalTrials.gov
NCT02123823XENTUZUMABPHASE12025-07-15ClinicalTrials.gov
NCT01498952DUSIGITUMABPHASE12019-02-19ClinicalTrials.gov
NCT01446159DUSIGITUMABPHASE22018-08-28ClinicalTrials.gov

NIH grants 22988

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant2742,025NIH's project files
P30CA008748Cancer Center Support Grant1332,025NIH's project files
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)1242,025NIH's project files
P30DK036836Diabetes Research Center772,025NIH's project files
P30CA006973Regional Oncology Research Center702,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)552,025NIH's project files
P30DK020541NYR-Diabetes Research Center (NYR-DRC)502,025NIH's project files
P30DK048520Colorado Nutrition Obesity Research Center502,025NIH's project files
P30DK056341Washington University Nutrition Obesity Research Center482,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award462,025NIH's project files

Papers 85536

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826315PubTator, text miningPubMed
42826047PubTator, text miningPubMed
42825287PubTator, text miningPubMed
42824949PubTator, text miningPubMed
42824137PubTator, text miningPubMed
42818942PubTator, text miningPubMed
42816879PubTator, text miningPubMed
42816254PubTator, text miningPubMed
42812993PubTator, text miningPubMed
42812268PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license