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APOE: apolipoprotein E

1 protein, 264 patents, 0 drugs, 0 trials, 22,367 NIH grants and 64,067 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolAPOEHGNC
Nameapolipoprotein EHGNC
NCBI Gene ID348NCBI Gene
HGNC IDHGNC:613HGNC
EnsemblENSG00000130203NCBI Gene
AliasesAD2, APO-E, ApoE4, LDLCQ5, LPGNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P02649Apolipoprotein E31729Ensembl, GeneID, HGNCUniProt

Patents 264

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026213425 A12026-10-082P02649Espacenet
JP 2026062949 A2026-04-102P02649Espacenet
JP 2026041903 A2026-03-108P02649Espacenet
JP 2026004568 A2026-01-1437676P02649Espacenet
EP 4670794 A22025-12-3137P02649Espacenet
US 12502368 B22025-12-232P02649Espacenet
EP 4650780 A22025-11-191388P02649Espacenet
EP 4640849 A22025-10-29163P02649Espacenet
EP 4641201 A22025-10-291023P02649Espacenet
JP 2025163078 A2025-10-281P02649Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 22367

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)5322,025NIH's project files
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study3962,025NIH's project files
P30AG066444Alzheimer's Disease Research Center2752,025NIH's project files
P30AG062715Wisconsin Alzheimer's Disease Research Center2332,025NIH's project files
R01NS017950Precursors of Stroke Incidence and Prognosis2112,025NIH's project files
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions1932,025NIH's project files
P30AG062429UCSD Shiley-Marcos Alzheimer's Disease Research Center P301832,025NIH's project files
P30AG062421Massachusetts Alzheimer's Disease Research Center (MADRC)1812,025NIH's project files
P30AG062422New Approaches to Dementia Heterogeneity1792,025NIH's project files
P30AG072975Rush Alzheimer's Disease Research Center1722,025NIH's project files

Papers 64067

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826610PubTator, text miningPubMed
42826448PubTator, text miningPubMed
42825842PubTator, text miningPubMed
42825653PubTator, text miningPubMed
42825454PubTator, text miningPubMed
42824271PubTator, text miningPubMed
42821566PubTator, text miningPubMed
42819539PubTator, text miningPubMed
42818935PubTator, text miningPubMed
42818907PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license