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IGF1R: insulin like growth factor 1 receptor

1 protein, 311 patents, 21 drugs, 192 trials, 10,258 NIH grants and 27,172 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIGF1RHGNC
Nameinsulin like growth factor 1 receptorHGNC
NCBI Gene ID3480NCBI Gene
HGNC IDHGNC:5465HGNC
EnsemblENSG00000140443NCBI Gene
AliasesCD221, IGFIR, IGFR, JTK13, MGC18216NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P08069Insulin-like growth factor 1 receptor1,36746Ensembl, GeneID, HGNCUniProt

Patents 311

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12624110 B22026-05-12410P08069Espacenet
JP 2026513844 A2026-05-0145P08069Espacenet
EP 4688861 A12026-02-1145P08069Espacenet
JP 2026004290 A2026-01-14174P08069Espacenet
KR 1020250169596 A2025-12-0345P08069Espacenet
EP 4650780 A22025-11-1919575P08069Espacenet
EP 4640849 A22025-10-294056P08069Espacenet
EP 4641201 A22025-10-2925273P08069Espacenet
EP 4641202 A22025-10-291403P08069Espacenet
EP 4641203 A22025-10-29776P08069Espacenet

Drugs 21

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AEW-541CHEMBL551064Insulin-like growth factor I receptor inhibitorINHIBITORChEMBL
AXL-1717CHEMBL283120Insulin-like growth factor I receptor inhibitorINHIBITORChEMBL
BIIB-022CHEMBL2109356Insulin-like growth factor I receptor inhibitorINHIBITORChEMBL
BMS-754807CHEMBL575448Insulin-like growth factor I receptor inhibitorINHIBITORChEMBL
CIXUTUMUMABCHEMBL1743001Insulin-like growth factor I receptor antagonistANTAGONISTChEMBL
CONTELTINIBCHEMBL3899477Insulin-like growth factor I receptor inhibitorINHIBITORChEMBL
DALOTUZUMABCHEMBL1743006Insulin-like growth factor I receptor antagonistANTAGONISTChEMBL
FIGITUMUMABCHEMBL1743019Insulin-like growth factor I receptor antagonistANTAGONISTChEMBL
GANITUMABCHEMBL1743024Insulin-like growth factor I receptor antagonistANTAGONISTChEMBL
ISTIRATUMABCHEMBL3989990Insulin-like growth factor I receptor inhibitorINHIBITORChEMBL

Trials 192

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07594912TEPROTUMUMABPHASE2ClinicalTrials.gov
NCT06866548TEPROTUMUMABEARLY_PHASE1ClinicalTrials.gov
NCT06389578TEPROTUMUMABPHASE1ClinicalTrials.gov
NCT06248619TEPROTUMUMABPHASE3ClinicalTrials.gov
NCT05580445CONTELTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT05002998TEPROTUMUMABPHASE4ClinicalTrials.gov
NCT04583735TEPROTUMUMABPHASE42024-04-26ClinicalTrials.gov
NCT04478994TEPROTUMUMABPHASE12024-04-19ClinicalTrials.gov
NCT04129151GANITUMABPHASE22024-07-17ClinicalTrials.gov
NCT03878992MECASERMINClinicalTrials.gov

NIH grants 10258

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant3242,025NIH's project files
P30CA008748Cancer Center Support Grant1542,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant522,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant472,025NIH's project files
P30CA068485Cancer Center Support Grant462,025NIH's project files
P30DK036836Diabetes Research Center462,025NIH's project files
P30CA006973Regional Oncology Research Center442,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase432,025NIH's project files
P30CA016058Cancer Center Support Grant342,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award322,025NIH's project files

Papers 27172

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824949PubTator, text miningPubMed
42823507PubTator, text miningPubMed
42817866PubTator, text miningPubMed
42811469PubTator, text miningPubMed
42810895PubTator, text miningPubMed
42810657PubTator, text miningPubMed
42810536PubTator, text miningPubMed
42809423PubTator, text miningPubMed
42807934PubTator, text miningPubMed
42797458PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license