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IGF2: insulin like growth factor 2

1 protein, 303 patents, 2 drugs, 9 trials, 8,095 NIH grants and 20,934 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIGF2HGNC
Nameinsulin like growth factor 2HGNC
NCBI Gene ID3481NCBI Gene
HGNC IDHGNC:5466HGNC
EnsemblENSG00000167244NCBI Gene
AliasesC11orf43, FLJ44734, GRDF, IGF-II, PP9974, SRS3NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P01344Insulin-like growth factor 218016Ensembl, GeneID, HGNCUniProt

Patents 303

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4810610 A22026-09-2332P01344Espacenet
EP 4773988 A12026-07-1515P01344Espacenet
EP 4650780 A22025-11-1910450P01344Espacenet
WO 2025219976 A12025-10-231P01344Espacenet
WO 2025219976 A12025-10-232P01344Espacenet
US 12447198 B22025-10-211P01344Espacenet
US 12447198 B22025-10-212P01344Espacenet
JP 2025147176 A2025-10-066774P01344Espacenet
JP 2025147176 A2025-10-066775P01344Espacenet
JP 2025147176 A2025-10-066776P01344Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DUSIGITUMABCHEMBL2109355Insulin-like growth factor II inhibitorINHIBITORChEMBL
XENTUZUMABCHEMBL4297850Insulin-like growth factor II inhibitorINHIBITORChEMBL

Trials 9

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05110495XENTUZUMABEARLY_PHASE12025-02-17ClinicalTrials.gov
NCT03659136XENTUZUMABPHASE22022-09-29ClinicalTrials.gov
NCT03099174XENTUZUMABPHASE12025-06-24ClinicalTrials.gov
NCT02204072XENTUZUMABPHASE12025-07-15ClinicalTrials.gov
NCT02191891XENTUZUMABPHASE12025-06-25ClinicalTrials.gov
NCT02145741XENTUZUMABPHASE12025-06-19ClinicalTrials.gov
NCT02123823XENTUZUMABPHASE12025-07-15ClinicalTrials.gov
NCT01498952DUSIGITUMABPHASE12019-02-19ClinicalTrials.gov
NCT01446159DUSIGITUMABPHASE22018-08-28ClinicalTrials.gov

NIH grants 8095

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant942,025NIH's project files
P30CA008748Cancer Center Support Grant552,025NIH's project files
P30ES017885Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)252,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)242,025NIH's project files
R01AA011431FASD Inhibition of ASPH-Notch Mediates Adolescent Cerebral White Matter Pathology-Potential Utility of Non-invasive Extracellular Vesicle Assays232,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)222,025NIH's project files
P30DK036836Diabetes Research Center222,025NIH's project files
P30CA006973Regional Oncology Research Center192,025NIH's project files
P50CA116201Mayo Clinic Breast Cancer SPORE192,025NIH's project files
U01CA167552Cancer Epidemiology Cohort in Male Health Professionals192,025NIH's project files

Papers 20934

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826893PubTator, text miningPubMed
42822432PubTator, text miningPubMed
42820309PubTator, text miningPubMed
42814875PubTator, text miningPubMed
42811810PubTator, text miningPubMed
42778655PubTator, text miningPubMed
42761829PubTator, text miningPubMed
42761218PubTator, text miningPubMed
42758452PubTator, text miningPubMed
42749046PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license