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IGFBP3: insulin like growth factor binding protein 3

1 protein, 105 patents, 0 drugs, 0 trials, 5,866 NIH grants and 15,607 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIGFBP3HGNC
Nameinsulin like growth factor binding protein 3HGNC
NCBI Gene ID3486NCBI Gene
HGNC IDHGNC:5472HGNC
EnsemblENSG00000146674NCBI Gene
AliasesBP-53, IBP-3, IBP3, IGFBP-3NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P17936Insulin-like growth factor-binding protein 32911Ensembl, GeneID, HGNCUniProt

Patents 105

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-192947P17936Espacenet
EP 4641201 A22025-10-292507P17936Espacenet
EP 4641203 A22025-10-2997P17936Espacenet
JP 2025147176 A2025-10-066792P17936Espacenet
JP 2025529142 A2025-09-046673P17936Espacenet
US 12371689 B22025-07-296673P17936Espacenet
JP 2025517967 A2025-06-1297P17936Espacenet
JP 2025517969 A2025-06-122507P17936Espacenet
JP 2025517970 A2025-06-122947P17936Espacenet
EP 4520828 A22025-03-1231P17936Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 5866

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant682,025NIH's project files
T32GM008256Postdoctoral Training in Trauma and Burns312,025NIH's project files
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)252,025NIH's project files
P30DK063491Diabetes Research Center (DRC)222,025NIH's project files
P30CA008748Cancer Center Support Grant212,025NIH's project files
P30CA006973Regional Oncology Research Center192,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)182,025NIH's project files
R01EY017017Dietary control of angiogenesis in retinopathy models172,025NIH's project files
T32CA009001Program for Training in Cancer Epidemiology172,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant162,025NIH's project files

Papers 15607

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822803PubTator, text miningPubMed
42814875PubTator, text miningPubMed
42798838PubTator, text miningPubMed
42784734PubTator, text miningPubMed
42781628PubTator, text miningPubMed
42781330PubTator, text miningPubMed
42759407PubTator, text miningPubMed
42754985PubTator, text miningPubMed
42754788PubTator, text miningPubMed
42736152PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license