Gene · 3487
IGFBP4: insulin like growth factor binding protein 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. IGFBP4: insulin like growth factor binding protein 4. Genes, record 3487. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3487
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P22692 | Insulin-like growth factor-binding protein 4 | 258 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents111
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12606639 B2 | 2026-04-21 | 7 | P22692 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 49924 | P22692 | Espacenet |
| WO 2025242652 A1 | 2025-11-27 | 7 | P22692 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2714 | P22692 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 6798 | P22692 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6674 | P22692 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6674 | P22692 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2714 | P22692 | Espacenet |
| JP 2025508362 A | 2025-03-26 | 2 | P22692 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 6798 | P22692 | Espacenet |
1 to 10 of 111
See all 111 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,584
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | IGFBP4 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 10 | 2025 |
| T32DK007352 | Diabetes and Metabolism | 9 | 2025 |
| P30CA047904 | Cancer Center Support Grant | 6 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 6 | 2025 |
| P50CA116201 | Mayo Clinic Breast Cancer SPORE | 6 | 2025 |
| P50CA136393 | Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancer | 6 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 5 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 4 | 2025 |
| P30CA138313 | Medical University of South Carolina - Cancer Center Support Grant | 4 | 2025 |
| P30CA006516 | Dana-Farber/Harvard Cancer Center | 3 | 2025 |
1 to 10 of 1,584Source NIH's project files
See all 1,584 nih grantsPapers2,963
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| NT-IGFBP-4: A novel biomarker for risk prediction in acute heart failure. | Clin Chim Acta | 2027 | 42419668 | PubTator, text mining | PubMed |
| PROFET predicts continuous gene expression dynamics from scRNA-seq data to elucidate heterogeneity of cancer treatment responses. | Cell Syst | 2026 | 42664975 | PubTator, text mining | PubMed |
| Circulating IGFBP-7 in Obstructive Sleep Apnea: A Single-Cohort Preliminary Assessment of Its Diagnostic Performance and Post-Treatment Dynamics. | Biomedicines | 2026 | 42652163 | PubTator, text mining | PubMed |
| miR-27b-3p Exacerbates VCD-Induced KGN Cell Injury by Targeting PAPPA to Suppress IGF-1 Release and Inhibit the PI3K/AKT Pathway. | Genes (Basel) | 2026 | 42650159 | PubTator, text mining | PubMed |
| Integrating machine learning and multi-omics analysis to identify and validate key genes associated with periodontitis. | Acta Odontol Scand | 2026 | 42615493 | PubTator, text mining | PubMed |
| Neonatal impact of maternal biomarker screening for risk of preterm birth with targeted interventions (PRIME): A multicenter, randomized, controlled trial. | Pregnancy (Hoboken) | 2026 | 42597049 | PubTator, text mining | PubMed |
| Prognostic Values of Pregnancy-Associated Plasma Protein-A and IGF-Binding Protein-4 Fragments in Patients with Acute Myocardial Infarction. | J Clin Med | 2026 | 42589864 | PubTator, text mining | PubMed |
| Size in small-for-gestational-age neonates correlates with insulin-like growth factor-binding protein proteolysis and insulin-like growth factor-I bioavailability. | J Endocr Soc | 2026 | 42491477 | PubTator, text mining | PubMed |
| Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling. | Adv Sci (Weinh) | 2026 | 42460631 | PubTator, text mining | PubMed |
| Chronic kidney disease-stratified plasma proteomic signatures of probable sarcopenia: A UK biobank cohort study. | Clin Nutr ESPEN | 2026 | 42456803 | PubTator, text mining | PubMed |
1 to 10 of 2,963
See all 2,963 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3487
GET https://conductscience.org/api/genes/v1/3487/patents?page=2