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Gene · 3487

IGFBP4: insulin like growth factor binding protein 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IGFBP4: insulin like growth factor binding protein 4. Genes, record 3487. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3487

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Gene

Symbol
IGFBP4
HGNC
Name
insulin like growth factor binding protein 4
HGNC
NCBI Gene ID
3487
NCBI Gene
HGNC ID
HGNC:5473
HGNC
Ensembl
ENSG00000141753
NCBI Gene
Aliases
BP-4, HT29-IGFBP, IBP4, IGFBP-4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P22692Insulin-like growth factor-binding protein 42584Ensembl, GeneID, HGNC

Source UniProt

Patents111

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12606639 B22026-04-217P22692Espacenet
JP 2026004568 A2026-01-1449924P22692Espacenet
WO 2025242652 A12025-11-277P22692Espacenet
EP 4650780 A22025-11-192714P22692Espacenet
JP 2025147176 A2025-10-066798P22692Espacenet
JP 2025529142 A2025-09-046674P22692Espacenet
US 12371689 B22025-07-296674P22692Espacenet
JP 2025517970 A2025-06-122714P22692Espacenet
JP 2025508362 A2025-03-262P22692Espacenet
JP 2025028160 A2025-02-286798P22692Espacenet

1 to 10 of 111

See all 111 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,584

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIGFBP4 papersNewest fiscal year
P30CA008748Cancer Center Support Grant102025
T32DK007352Diabetes and Metabolism92025
P30CA047904Cancer Center Support Grant62025
P30CA068485Cancer Center Support Grant62025
P50CA116201Mayo Clinic Breast Cancer SPORE62025
P50CA136393Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancer62025
P30DK020572Michigan Diabetes Research Center (MDRC)52025
P30CA016087Cancer Center Support Grant42025
P30CA138313Medical University of South Carolina - Cancer Center Support Grant42025
P30CA006516Dana-Farber/Harvard Cancer Center32025

1 to 10 of 1,584Source NIH's project files

See all 1,584 nih grants

Papers2,963

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
NT-IGFBP-4: A novel biomarker for risk prediction in acute heart failure.Clin Chim Acta202742419668PubTator, text miningPubMed
PROFET predicts continuous gene expression dynamics from scRNA-seq data to elucidate heterogeneity of cancer treatment responses.Cell Syst202642664975PubTator, text miningPubMed
Circulating IGFBP-7 in Obstructive Sleep Apnea: A Single-Cohort Preliminary Assessment of Its Diagnostic Performance and Post-Treatment Dynamics.Biomedicines202642652163PubTator, text miningPubMed
miR-27b-3p Exacerbates VCD-Induced KGN Cell Injury by Targeting PAPPA to Suppress IGF-1 Release and Inhibit the PI3K/AKT Pathway.Genes (Basel)202642650159PubTator, text miningPubMed
Integrating machine learning and multi-omics analysis to identify and validate key genes associated with periodontitis.Acta Odontol Scand202642615493PubTator, text miningPubMed
Neonatal impact of maternal biomarker screening for risk of preterm birth with targeted interventions (PRIME): A multicenter, randomized, controlled trial.Pregnancy (Hoboken)202642597049PubTator, text miningPubMed
Prognostic Values of Pregnancy-Associated Plasma Protein-A and IGF-Binding Protein-4 Fragments in Patients with Acute Myocardial Infarction.J Clin Med202642589864PubTator, text miningPubMed
Size in small-for-gestational-age neonates correlates with insulin-like growth factor-binding protein proteolysis and insulin-like growth factor-I bioavailability.J Endocr Soc202642491477PubTator, text miningPubMed
Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling.Adv Sci (Weinh)202642460631PubTator, text miningPubMed
Chronic kidney disease-stratified plasma proteomic signatures of probable sarcopenia: A UK biobank cohort study.Clin Nutr ESPEN202642456803PubTator, text miningPubMed

1 to 10 of 2,963

See all 2,963 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3487

GET https://conductscience.org/api/genes/v1/3487/patents?page=2