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Gene · 3488

IGFBP5: insulin like growth factor binding protein 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IGFBP5: insulin like growth factor binding protein 5. Genes, record 3488. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3488

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Gene

Symbol
IGFBP5
HGNC
Name
insulin like growth factor binding protein 5
HGNC
NCBI Gene ID
3488
NCBI Gene
HGNC ID
HGNC:5474
HGNC
Ensembl
ENSG00000115461
NCBI Gene
Aliases
IBP5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P24593Insulin-like growth factor-binding protein 52723Ensembl, GeneID, HGNC

Source UniProt

Patents98

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12606639 B22026-04-2112P24593Espacenet
WO 2025242652 A12025-11-2712P24593Espacenet
EP 4650780 A22025-11-19866P24593Espacenet
JP 2025147176 A2025-10-066799P24593Espacenet
JP 2025529142 A2025-09-046675P24593Espacenet
US 12371689 B22025-07-296675P24593Espacenet
JP 2025517970 A2025-06-12866P24593Espacenet
JP 2025032204 A2025-03-1129861P24593Espacenet
JP 2025028160 A2025-02-286799P24593Espacenet
KR 1020250010750 A2025-01-216799P24593Espacenet

1 to 10 of 98

See all 98 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,380

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIGFBP5 papersNewest fiscal year
P30CA016672Cancer Center Support Grant212025
P50CA116201Mayo Clinic Breast Cancer SPORE122025
K24AR060297Scleroderma Twin Study and analysis of Estrogen in patients with dcSSc102025
P30CA068485Cancer Center Support Grant92025
ZIACP010126Hormone-Related Cancers72025
P30CA016056Roswell Park Cancer Center Support Grant62025
P50CA136393Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancer62025
T32DK007665Metabolism and Nutrition Training Program62025
P30CA006927Comprehensive Cancer Center Program at Fox Chase52025
P30CA016058Cancer Center Support Grant52025

1 to 10 of 2,380Source NIH's project files

See all 2,380 nih grants

Papers3,939

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Spatial transcriptomic analysis of neurons at the glioma infiltration front: A case study.Brain Pathol202642808225PubTator, text miningPubMed
Integrated First-Trimester Assessment of Placental Biomarkers, Metabolic Indices, and IGF-1/IGFBP-5 in Relation to Subsequent Gestational Diabetes Mellitus: A Prospective Cohort Study.Medicina (Kaunas)202642796410PubTator, text miningPubMed
Unravelling the Impact of Diabetes on Insulin-like Growth Factor (IGF) Axis Signalling in Mesenchymal Stem Cells Isolated from the Bone of Knee Joints.Bioengineering (Basel)202642791915PubTator, text miningPubMed
Integrated plasma proteomic and metabolomic profiling demonstrated specific proteins and bile acids remodeling after liver transplantation of children with biliary atresia.Biochim Biophys Acta Proteins Proteom202642777789PubTator, text miningPubMed
Identification of Gene Signatures and Molecular Mechanisms Underlying the Comorbidity of Alzheimer's Disease and Crohn's Disease Using Machine Learning.Psychiatry Investig202642765175PubTator, text miningPubMed
IGFBP5 alleviates periodontitis by reversing human dental follicle stem cell senescence via the non-canonical Wnt pathway.Int J Oral Sci202642736271PubTator, text miningPubMed
Integrative multi-omics analyses suggest a candidate microbial metabolite-associated host gene network in ulcerative colitis.Immunol Res202642696087PubTator, text miningPubMed
Multi-omics analysis identifies fibroblast IGFBP5 as a key target of anti-TNFα therapy in ulcerative colitis.Front Immunol202642694691PubTator, text miningPubMed
Corrigendum to "IGFBP5 suppresses colorectal cancer stemness and carcinogenesis via binding to GPR182 and inhibiting PKCα/AKT/P70S6K axis" [Biochem. Pharmacol. 252 (2026) 118223].Biochem Pharmacol202642648204PubTator, text miningPubMed
Caspase-8 as a candidate mediator associated with everolimus resistance in neuroendocrine tumors.J Mol Endocrinol202642615220PubTator, text miningPubMed

1 to 10 of 3,939

See all 3,939 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3488

GET https://conductscience.org/api/genes/v1/3488/patents?page=2