Gene · 3488
IGFBP5: insulin like growth factor binding protein 5
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. IGFBP5: insulin like growth factor binding protein 5. Genes, record 3488. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3488
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P24593 | Insulin-like growth factor-binding protein 5 | 272 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents98
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12606639 B2 | 2026-04-21 | 12 | P24593 | Espacenet |
| WO 2025242652 A1 | 2025-11-27 | 12 | P24593 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 866 | P24593 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 6799 | P24593 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6675 | P24593 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6675 | P24593 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 866 | P24593 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 29861 | P24593 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 6799 | P24593 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 6799 | P24593 | Espacenet |
1 to 10 of 98
See all 98 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,380
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | IGFBP5 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 21 | 2025 |
| P50CA116201 | Mayo Clinic Breast Cancer SPORE | 12 | 2025 |
| K24AR060297 | Scleroderma Twin Study and analysis of Estrogen in patients with dcSSc | 10 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 9 | 2025 |
| ZIACP010126 | Hormone-Related Cancers | 7 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 6 | 2025 |
| P50CA136393 | Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancer | 6 | 2025 |
| T32DK007665 | Metabolism and Nutrition Training Program | 6 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 5 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 5 | 2025 |
1 to 10 of 2,380Source NIH's project files
See all 2,380 nih grantsPapers3,939
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Spatial transcriptomic analysis of neurons at the glioma infiltration front: A case study. | Brain Pathol | 2026 | 42808225 | PubTator, text mining | PubMed |
| Integrated First-Trimester Assessment of Placental Biomarkers, Metabolic Indices, and IGF-1/IGFBP-5 in Relation to Subsequent Gestational Diabetes Mellitus: A Prospective Cohort Study. | Medicina (Kaunas) | 2026 | 42796410 | PubTator, text mining | PubMed |
| Unravelling the Impact of Diabetes on Insulin-like Growth Factor (IGF) Axis Signalling in Mesenchymal Stem Cells Isolated from the Bone of Knee Joints. | Bioengineering (Basel) | 2026 | 42791915 | PubTator, text mining | PubMed |
| Integrated plasma proteomic and metabolomic profiling demonstrated specific proteins and bile acids remodeling after liver transplantation of children with biliary atresia. | Biochim Biophys Acta Proteins Proteom | 2026 | 42777789 | PubTator, text mining | PubMed |
| Identification of Gene Signatures and Molecular Mechanisms Underlying the Comorbidity of Alzheimer's Disease and Crohn's Disease Using Machine Learning. | Psychiatry Investig | 2026 | 42765175 | PubTator, text mining | PubMed |
| IGFBP5 alleviates periodontitis by reversing human dental follicle stem cell senescence via the non-canonical Wnt pathway. | Int J Oral Sci | 2026 | 42736271 | PubTator, text mining | PubMed |
| Integrative multi-omics analyses suggest a candidate microbial metabolite-associated host gene network in ulcerative colitis. | Immunol Res | 2026 | 42696087 | PubTator, text mining | PubMed |
| Multi-omics analysis identifies fibroblast IGFBP5 as a key target of anti-TNFα therapy in ulcerative colitis. | Front Immunol | 2026 | 42694691 | PubTator, text mining | PubMed |
| Corrigendum to "IGFBP5 suppresses colorectal cancer stemness and carcinogenesis via binding to GPR182 and inhibiting PKCα/AKT/P70S6K axis" [Biochem. Pharmacol. 252 (2026) 118223]. | Biochem Pharmacol | 2026 | 42648204 | PubTator, text mining | PubMed |
| Caspase-8 as a candidate mediator associated with everolimus resistance in neuroendocrine tumors. | J Mol Endocrinol | 2026 | 42615220 | PubTator, text mining | PubMed |
1 to 10 of 3,939
See all 3,939 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3488
GET https://conductscience.org/api/genes/v1/3488/patents?page=2