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Gene · 3489

IGFBP6: insulin like growth factor binding protein 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IGFBP6: insulin like growth factor binding protein 6. Genes, record 3489. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3489

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Gene

Symbol
IGFBP6
HGNC
Name
insulin like growth factor binding protein 6
HGNC
NCBI Gene ID
3489
NCBI Gene
HGNC ID
HGNC:5475
HGNC
Ensembl
ENSG00000167779
NCBI Gene
Aliases
IBP6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P24592Insulin-like growth factor-binding protein 62402Ensembl, GeneID, HGNC

Source UniProt

Patents63

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4663754 A22025-12-1715P24592Espacenet
EP 4650780 A22025-11-194081P24592Espacenet
JP 2025147176 A2025-10-066802P24592Espacenet
JP 2025529142 A2025-09-046676P24592Espacenet
US 12371689 B22025-07-296676P24592Espacenet
JP 2025517970 A2025-06-124081P24592Espacenet
JP 2025028160 A2025-02-286802P24592Espacenet
KR 1020250010750 A2025-01-216802P24592Espacenet
JP 2024109657 A2024-08-146809P24592Espacenet
JP 2023086836 A2023-06-2239P24592Espacenet

1 to 10 of 63

See all 63 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,131

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIGFBP6 papersNewest fiscal year
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant42025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant42025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)42025
P30ES006694Southwest Environmental Health Sciences Center42025
U19AG023122Longevity Consortium42025
UL1TR001863Yale Clinical and Translational Science Award42025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures42025
P30CA013330Cancer Center Support Grant32025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant32025
P30CA016058Cancer Center Support Grant32025

1 to 10 of 1,131Source NIH's project files

See all 1,131 nih grants

Papers1,836

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrative multi-omics analysis prioritizes compartment-specific candidate targets of gut microbiota metabolites in diabetic kidney disease.Front Immunol202642756821PubTator, text miningPubMed
Author Correction: Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosis.Nat Cardiovasc Res202642661086PubTator, text miningPubMed
Insulin-Like Growth Factor 2 Modulates Macrophage Polarization: the Role of the IGF2-IGFBP6 Axis.Dokl Biochem Biophys202642545576PubTator, text miningPubMed
Ubiquitin-Proteasome System-Related Prognostic Model and Immune Landscape in Glioblastoma.Int J Genomics202642488132PubTator, text miningPubMed
Biomarker profiles in idiopathic and progressive pulmonary fibrosis after LPA1 antagonism: exploratory analysis from a phase 2 trial of admilparant.Respir Res202642458495PubTator, text miningPubMed
IGFBP-6 regulates SH2D4A expression to promote breast cancer cell cycle progression in response to progesterone.Front Endocrinol (Lausanne)202642453504PubTator, text miningPubMed
Paired plasma and EV-enriched plasma proteomics reveal nonredundant sepsis-associated host-response signatures in critical illness.medRxiv202642396339PubTator, text miningPubMed
The CXXC1-IGFBP6 Axis Maintains Corneal Epithelial Differentiation via H3K4me3-Dependent Transcriptional Activation.Invest Ophthalmol Vis Sci202642390171PubTator, text miningPubMed
Insulin-like growth factor binding proteins in metabolic dysfunction-associated steatotic liver disease.Front Endocrinol (Lausanne)202642325621PubTator, text miningPubMed
IGF-II, IGFBP-4, -6, and -7, and HMGB1 show changes in follicular fluid in PCOS.Front Endocrinol (Lausanne)202642325612PubTator, text miningPubMed

1 to 10 of 1,836

See all 1,836 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/3489

GET https://conductscience.org/api/genes/v1/3489/patents?page=2