Gene · 3489
IGFBP6: insulin like growth factor binding protein 6
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. IGFBP6: insulin like growth factor binding protein 6. Genes, record 3489. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/3489
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P24592 | Insulin-like growth factor-binding protein 6 | 240 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents63
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4663754 A2 | 2025-12-17 | 15 | P24592 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 4081 | P24592 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 6802 | P24592 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6676 | P24592 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6676 | P24592 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4081 | P24592 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 6802 | P24592 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 6802 | P24592 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 6809 | P24592 | Espacenet |
| JP 2023086836 A | 2023-06-22 | 39 | P24592 | Espacenet |
1 to 10 of 63
See all 63 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,131
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | IGFBP6 papers | Newest fiscal year |
|---|---|---|---|
| P30CA023074 | University of Arizona Cancer Center - Cancer Center Support Grant | 4 | 2025 |
| P30CA051008 | Georgetown University Lombardi Comprehensive Cancer Center Support Grant | 4 | 2025 |
| P30DK020541 | NYR-Diabetes Research Center (NYR-DRC) | 4 | 2025 |
| P30ES006694 | Southwest Environmental Health Sciences Center | 4 | 2025 |
| U19AG023122 | Longevity Consortium | 4 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 4 | 2025 |
| ZIACP010121 | Molecular Epidemiology Studies of Occupational and Environmental Exposures | 4 | 2025 |
| P30CA013330 | Cancer Center Support Grant | 3 | 2025 |
| P30CA015083 | Mayo Clinic Comprehensive Cancer Center Support Grant | 3 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,131Source NIH's project files
See all 1,131 nih grantsPapers1,836
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Integrative multi-omics analysis prioritizes compartment-specific candidate targets of gut microbiota metabolites in diabetic kidney disease. | Front Immunol | 2026 | 42756821 | PubTator, text mining | PubMed |
| Author Correction: Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosis. | Nat Cardiovasc Res | 2026 | 42661086 | PubTator, text mining | PubMed |
| Insulin-Like Growth Factor 2 Modulates Macrophage Polarization: the Role of the IGF2-IGFBP6 Axis. | Dokl Biochem Biophys | 2026 | 42545576 | PubTator, text mining | PubMed |
| Ubiquitin-Proteasome System-Related Prognostic Model and Immune Landscape in Glioblastoma. | Int J Genomics | 2026 | 42488132 | PubTator, text mining | PubMed |
| Biomarker profiles in idiopathic and progressive pulmonary fibrosis after LPA1 antagonism: exploratory analysis from a phase 2 trial of admilparant. | Respir Res | 2026 | 42458495 | PubTator, text mining | PubMed |
| IGFBP-6 regulates SH2D4A expression to promote breast cancer cell cycle progression in response to progesterone. | Front Endocrinol (Lausanne) | 2026 | 42453504 | PubTator, text mining | PubMed |
| Paired plasma and EV-enriched plasma proteomics reveal nonredundant sepsis-associated host-response signatures in critical illness. | medRxiv | 2026 | 42396339 | PubTator, text mining | PubMed |
| The CXXC1-IGFBP6 Axis Maintains Corneal Epithelial Differentiation via H3K4me3-Dependent Transcriptional Activation. | Invest Ophthalmol Vis Sci | 2026 | 42390171 | PubTator, text mining | PubMed |
| Insulin-like growth factor binding proteins in metabolic dysfunction-associated steatotic liver disease. | Front Endocrinol (Lausanne) | 2026 | 42325621 | PubTator, text mining | PubMed |
| IGF-II, IGFBP-4, -6, and -7, and HMGB1 show changes in follicular fluid in PCOS. | Front Endocrinol (Lausanne) | 2026 | 42325612 | PubTator, text mining | PubMed |
1 to 10 of 1,836
See all 1,836 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/3489
GET https://conductscience.org/api/genes/v1/3489/patents?page=2