ConductScience.org, home

Gene · 348980

HCN1: hyperpolarization activated cyclic nucleotide gated potassium channel 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. HCN1: hyperpolarization activated cyclic nucleotide gated potassium channel 1. Genes, record 348980. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/348980

On this page

Gene

Symbol
HCN1
HGNC
Name
hyperpolarization activated cyclic nucleotide gated potassium channel 1
HGNC
NCBI Gene ID
348980
NCBI Gene
HGNC ID
HGNC:4845
HGNC
Ensembl
ENSG00000164588
NCBI Gene
Aliases
BCNG-1, BCNG1, DEE24, EIEE24, GEFSP10, HAC-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O60741Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 189017Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12516308 B22026-01-062440O60741Espacenet
EP 4641201 A22025-10-294040O60741Espacenet
JP 2025529142 A2025-09-041920O60741Espacenet
US 12371689 B22025-07-291920O60741Espacenet
JP 2025517969 A2025-06-124040O60741Espacenet
JP 2025032204 A2025-03-1129487O60741Espacenet
EP 4461818 A22024-11-1329487O60741Espacenet
US 11898179 B22024-02-132440O60741Espacenet
JP 2023058610 A2023-04-2529487O60741Espacenet
US 11446398 B22022-09-2039363O60741Espacenet

1 to 10 of 23

See all 23 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,087

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHCN1 papersNewest fiscal year
T32NS045540Epilepsy Research Training Program82025
R01HL135109Targeting the Arrhythmogenic Sources of Human Atrial Fibrillation72025
R35NS116850Biophysical mechanisms of gating and modulation in voltage-gated ion channel superfamily62025
P51OD010425Washington National Primate Research Center42025
UL1TR001863Yale Clinical and Translational Science Award42025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center32025
R01GM098592Structural and functional studies of Hsp70/Hsp110 molecular chaperones32025
R01HL085844Functional interactions of cardiac ion channels32025
T32HL007936Training Program in Translational Cardiovascular Science32025
T32HL086350Training Program in Basic and Translational Cardiovascular Science32025

1 to 10 of 1,087Source NIH's project files

See all 1,087 nih grants

Papers1,298

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Selective depletion of upper-layer somatostatin interneuron subtypes in schizophrenia.bioRxiv202642818094PubTator, text miningPubMed
Structural basis of isoform-specific cAMP regulation and autoinhibition in hyperpolarization-activated cyclic nucleotide-gated channels.J Biol Chem202642772566PubTator, text miningPubMed
Temperature dependence of HCN channel kinetics: A systematic comparison across mammalian isoforms and species.Exp Physiol202642669770PubTator, text miningPubMed
Blood transcriptomic signatures link β-amyloid deposition to molecular pathways across SCD, MCI, and dementia.Front Aging Neurosci202642529199PubTator, text miningPubMed
Response to anti-seizure medications in children carrying novel or previously reported HCN1 gene variants.Epilepsia Open202642524842PubTator, text miningPubMed
Seizure worsening and sodium-channel blockers in HCN1-related epilepsies: A case series.Dev Med Child Neurol202642499125PubTator, text miningPubMed
Relationship Between Patient Activation and Quality of Life in HCN1-Related Epilepsy.Juntendo Med J202642488018PubTator, text miningPubMed
The Hyperpolarization-Activated, Cyclic-Nucleotide (HCN) Ion Channel Inhibitors as Potential Therapy for Pain, CNS Disorders, Psychiatric Disorders, and Tinnitus.ACS Med Chem Lett202642445009PubTator, text miningPubMed
Precision treatment in HCN1-related epilepsies: Caution with sodium-channel blockers.Dev Med Child Neurol202642418727PubTator, text miningPubMed
Seizure worsening and sodium channel blockers in HCN1-related epilepsies: A case series.Dev Med Child Neurol202642357823PubTator, text miningPubMed

1 to 10 of 1,298

See all 1,298 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/348980

GET https://conductscience.org/api/genes/v1/348980/patents?page=2