Gene · 348980
HCN1: hyperpolarization activated cyclic nucleotide gated potassium channel 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. HCN1: hyperpolarization activated cyclic nucleotide gated potassium channel 1. Genes, record 348980. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/348980
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O60741 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | 890 | 17 | Ensembl, GeneID, HGNC |
Source UniProt
Patents23
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12516308 B2 | 2026-01-06 | 2440 | O60741 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 4040 | O60741 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1920 | O60741 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1920 | O60741 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 4040 | O60741 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 29487 | O60741 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 29487 | O60741 | Espacenet |
| US 11898179 B2 | 2024-02-13 | 2440 | O60741 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 29487 | O60741 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 39363 | O60741 | Espacenet |
1 to 10 of 23
See all 23 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,087
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | HCN1 papers | Newest fiscal year |
|---|---|---|---|
| T32NS045540 | Epilepsy Research Training Program | 8 | 2025 |
| R01HL135109 | Targeting the Arrhythmogenic Sources of Human Atrial Fibrillation | 7 | 2025 |
| R35NS116850 | Biophysical mechanisms of gating and modulation in voltage-gated ion channel superfamily | 6 | 2025 |
| P51OD010425 | Washington National Primate Research Center | 4 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 4 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 3 | 2025 |
| R01GM098592 | Structural and functional studies of Hsp70/Hsp110 molecular chaperones | 3 | 2025 |
| R01HL085844 | Functional interactions of cardiac ion channels | 3 | 2025 |
| T32HL007936 | Training Program in Translational Cardiovascular Science | 3 | 2025 |
| T32HL086350 | Training Program in Basic and Translational Cardiovascular Science | 3 | 2025 |
1 to 10 of 1,087Source NIH's project files
See all 1,087 nih grantsPapers1,298
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Selective depletion of upper-layer somatostatin interneuron subtypes in schizophrenia. | bioRxiv | 2026 | 42818094 | PubTator, text mining | PubMed |
| Structural basis of isoform-specific cAMP regulation and autoinhibition in hyperpolarization-activated cyclic nucleotide-gated channels. | J Biol Chem | 2026 | 42772566 | PubTator, text mining | PubMed |
| Temperature dependence of HCN channel kinetics: A systematic comparison across mammalian isoforms and species. | Exp Physiol | 2026 | 42669770 | PubTator, text mining | PubMed |
| Blood transcriptomic signatures link β-amyloid deposition to molecular pathways across SCD, MCI, and dementia. | Front Aging Neurosci | 2026 | 42529199 | PubTator, text mining | PubMed |
| Response to anti-seizure medications in children carrying novel or previously reported HCN1 gene variants. | Epilepsia Open | 2026 | 42524842 | PubTator, text mining | PubMed |
| Seizure worsening and sodium-channel blockers in HCN1-related epilepsies: A case series. | Dev Med Child Neurol | 2026 | 42499125 | PubTator, text mining | PubMed |
| Relationship Between Patient Activation and Quality of Life in HCN1-Related Epilepsy. | Juntendo Med J | 2026 | 42488018 | PubTator, text mining | PubMed |
| The Hyperpolarization-Activated, Cyclic-Nucleotide (HCN) Ion Channel Inhibitors as Potential Therapy for Pain, CNS Disorders, Psychiatric Disorders, and Tinnitus. | ACS Med Chem Lett | 2026 | 42445009 | PubTator, text mining | PubMed |
| Precision treatment in HCN1-related epilepsies: Caution with sodium-channel blockers. | Dev Med Child Neurol | 2026 | 42418727 | PubTator, text mining | PubMed |
| Seizure worsening and sodium channel blockers in HCN1-related epilepsies: A case series. | Dev Med Child Neurol | 2026 | 42357823 | PubTator, text mining | PubMed |
1 to 10 of 1,298
See all 1,298 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/348980
GET https://conductscience.org/api/genes/v1/348980/patents?page=2